Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Severin Filser"'
Autor:
Bernhard Groschup, Gian Marco Calandra, Constanze Raitmayr, Joshua Shrouder, Gemma Llovera, Asal Ghaffari Zaki, Sandra Burgstaller, Helmut Bischof, Emrah Eroglu, Arthur Liesz, Roland Malli, Severin Filser, Nikolaus Plesnila
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Neuronal activity is accompanied by a net outflow of potassium ions (K+) from the intra- to the extracellular space. While extracellular [K+] changes during neuronal activity are well characterized, intracellular dynamics have been less well
Externí odkaz:
https://doaj.org/article/5ae63432000d4fcca11bba7269b0eb71
Autor:
Tanja Blume, Severin Filser, Carmelo Sgobio, Finn Peters, Ulf Neumann, Derya Shimshek, Takashi Saito, Takaomi C. Saido, Matthias Brendel, Jochen Herms
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
All clinical BACE1-inhibitor trials for the treatment of Alzheimer's Disease (AD) have failed due to insufficient efficacy or side effects like worsening of cognitive symptoms. However, the scientific evidence to date suggests that BACE1-inhibition c
Externí odkaz:
https://doaj.org/article/144a3076274c42a3bf053f2023cbd80c
Autor:
Melanie Schoof, Michael Launspach, Dörthe Holdhof, Lynhda Nguyen, Verena Engel, Severin Filser, Finn Peters, Jana Immenschuh, Malte Hellwig, Judith Niesen, Volker Mall, Birgit Ertl-Wagner, Christian Hagel, Michael Spohn, Beat Lutz, Jan Sedlacik, Daniela Indenbirken, Daniel J. Merk, Ulrich Schüller
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. Germline mutations within the CBP gene are known
Externí odkaz:
https://doaj.org/article/6ca04c132be94fa7b691ec045f179d0f
Autor:
Manja Luckner, Steffen Burgold, Severin Filser, Maximilian Scheungrab, Yilmaz Niyaz, Eric Hummel, Gerhard Wanner, Jochen Herms
Publikováno v:
iScience, Vol 6, Iss , Pp 92-101 (2018)
Summary: Emerging 3D correlative light and electron microscopy approaches enable studying neuronal structure-function relations at unprecedented depth and precision. However, established protocols for the correlation of light and electron micrographs
Externí odkaz:
https://doaj.org/article/d34a351b7c6b4249bfdaf516b7a41e24
Autor:
Julia Ahlfeld, Severin Filser, Felix Schmidt, Annika K. Wefers, Daniel J. Merk, Rainer Glaß, Jochen Herms, Ulrich Schüller
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem cell markers Sox2 and Nestin, and lacks markers of glial or neuronal differentiation.
Externí odkaz:
https://doaj.org/article/aeba864d42ef41fea54c73bb5845c5de
Autor:
Tanja Blume, Severin Filser, Anna Jaworska, Jean-Francois Blain, Gerhard Koenig, Katrin Moschke, Stefan F. Lichtenthaler, Jochen Herms
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
Beta-site amyloid-precursor-protein cleaving enzyme 1 (BACE1) is the rate limiting protease in the production of the amyloid-beta peptide (Aβ), which is considered to be the causative agent in the pathogenesis of Alzheimer’s Disease (AD). Therefor
Externí odkaz:
https://doaj.org/article/f771853a2ac843e2a4813c8b74b84943
Autor:
Christian Schön, Nadine A Hoffmann, Simon M Ochs, Steffen Burgold, Severin Filser, Sonja Steinbach, Mathias W Seeliger, Thomas Arzberger, Michel Goedert, Hans A Kretzschmar, Boris Schmidt, Jochen Herms
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53547 (2012)
Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to impr
Externí odkaz:
https://doaj.org/article/8cbd5a5cfea742ec80e7019be1efada6
Autor:
Robert Lukowski, Sandra Burgstaller, Severin Filser, Nikolaus Plesnila, Bernhard Groschup, Thomas Rauter, Tony Schmidt, Philipp Sasse, Silke Patz, Lucas van den Boom, Helmut Bischof, Rainer Schindl, Wolfgang F. Graier, Roland Malli
Publikováno v:
ACS Sensors
Given the importance of ion gradients and fluxes in biology, monitoring ions locally at the exterior of the plasma membrane of intact cells in a noninvasive manner is highly desirable but challenging. Classical targeting of genetically encoded biosen
Autor:
Sonja Blumenstock, Jochen Herms, Carmelo Sgobio, Fanfan Sun, Severin Filser, Jose Medina-Luque, Armando G. Salinas
Publikováno v:
Brain Pathology
Brain pathology 32(2), e13036 (2022). doi:10.1111/bpa.13036
Brain pathology 32(2), e13036 (2022). doi:10.1111/bpa.13036
Misfolded alpha-synuclein spreads along anatomically connected areas through the brain, prompting progressive neurodegeneration of the nigrostriatal pathway in Parkinson's disease. To investigate the impact of early stage seeding and spreading of mis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51edb0cf7cd5166ab5359034bce8f792
https://hdl.handle.net/21.11116/0000-0009-988D-D21.11116/0000-0009-988F-B
https://hdl.handle.net/21.11116/0000-0009-988D-D21.11116/0000-0009-988F-B
Autor:
Tanja Blume, Severin Filser, Carmelo Sgobio, Finn Peters, Ulf Neumann, Derya Shimshek, Takashi Saito, Takaomi C. Saido, Matthias Brendel, Jochen Herms
Publikováno v:
Frontiers in aging neuroscience 14, 909586 (2022). doi:10.3389/fnagi.2022.909586
All clinical BACE1-inhibitor trials for the treatment of Alzheimer's Disease (AD) have failed due to insufficient efficacy or side effects like worsening of cognitive symptoms. However, the scientific evidence to date suggests that BACE1-inhibition c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4fec7fc0810bd1b1689852051075eb
https://pub.dzne.de/record/165178
https://pub.dzne.de/record/165178