Zobrazeno 1 - 10
of 904
pro vyhledávání: '"Severin, T."'
Autor:
Elizabeth M. Corteselli, Mona Sharafi, Robert Hondal, Maximilian MacPherson, Sheryl White, Ying-Wai Lam, Clarissa Gold, Allison M. Manuel, Albert van der Vliet, Severin T. Schneebeli, Vikas Anathy, Jianing Li, Yvonne M. W. Janssen-Heininger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases tha
Externí odkaz:
https://doaj.org/article/b5c9d223376f4a1cb9e9e02ac6e0d59e
Autor:
Remington, Jacob M., Liao, Chenyi, Sharafi, Mona, Marie, Emma Ste., Ferrell, Jonathon B., Hondal, Robert, Wargo, Matthew J., Schneebeli, Severin T., Li, Jianing
By integrating various simulation and experimental techniques, we discovered that antimicrobial peptides (AMPs) may achieve synergy at an optimal concentration and ratio, which can be caused by aggregation of the synergistic peptides. On multiple tim
Externí odkaz:
http://arxiv.org/abs/2010.00122
Akademický článek
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Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Structure-based drug design targeting the SARS-CoV-2 virus has been greatly facilitated by available virus-related protein structures. However, there is an urgent need for effective, safe small-molecule drugs to control the spread of the vir
Externí odkaz:
https://doaj.org/article/2821bc4e151f414ba4c52588287f8f20
Publikováno v:
Organic Materials, Vol 03, Iss 02, Pp 337-345 (2021)
Abstract We synthesized some of the longest unimolecular oligo(p-phenylene ethynylenes) (OPEs), which are fully substituted with electron-withdrawing ester groups. An iterative convergent/divergent (a.k.a. iterative exponential growth – IEG) strate
Externí odkaz:
https://doaj.org/article/65e85c25d7bc41329f41f1553739d29e
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The lack of biologically relevant protein structures can hinder rational design of small molecules to target G protein-coupled receptors (GPCRs). While ensemble docking using multiple models of the protein target is a promising technique for structur
Externí odkaz:
https://doaj.org/article/cf0dcf8afb874bad88fbd8103b278822
Autor:
Sharafi, Mona, McKay, Kyle T., Ivancic, Monika, McCarthy, Dillon R., Dudkina, Natavan, Murphy, Kyle E., Rajappan, Sinu C., Campbell, Joseph P., Shen, Yuxiang, Badireddy, Appala Raju, Li, Jianing, Schneebeli, Severin T.
Publikováno v:
In Chem 11 June 2020 6(6):1469-1494
Akademický článek
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Autor:
Chen, Wenbo, Widawsky, Jonathan R., Vázquez, Héctor, Schneebeli, Severin T., Hybertsen, Mark S., Breslow, Ronald, Venkataraman, Latha
We measure electronic conductance through single conjugated molecules bonded to Au metal electrodes with direct Au-C covalent bonds using the scanning tunneling microscope based break-junction technique. We start with molecules terminated with trimet
Externí odkaz:
http://arxiv.org/abs/1110.0344
Autor:
Tyler J. Jaynes, Mona Sharafi, Joseph P. Campbell, Jessica Bocanegra, Kyle T. McKay, Kassondra Little, Reilly Osadchey Brown, Danielle L. Gray, Toby J. Woods, Jianing Li, Severin T. Schneebeli
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
This work presents the first transition metal-free synthesis of oxygen-linked aromatic polymers by integrating iterative exponential polymer growth (IEG) with nucleophilic aromatic substitution (SNAr) reactions. Our approach applies methyl sulfones a
Externí odkaz:
https://doaj.org/article/54d5f6dd58f64d3dbc7852b28719d395