Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sevasti Zervou"'
Autor:
Mahon L. Maguire, Debra J. McAndrew, Hannah A. Lake, Philip J. Ostrowski, Sevasti Zervou, Stefan Neubauer, Craig A. Lygate, Jurgen E. Schneider
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-10 (2023)
Abstract Background Phosphorus cardiovascular magnetic resonance spectroscopy (31P-CMRS) has emerged as an important tool for the preclinical assessment of myocardial energetics in vivo. However, the high rate and diminutive size of the mouse heart i
Externí odkaz:
https://doaj.org/article/2f14a28b965446bc9091be7fea4b46e5
Autor:
Debra J. McAndrew, Hannah A. Lake, Sevasti Zervou, Edzard Schwedhelm, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
ESC Heart Failure, Vol 10, Iss 1, Pp 189-199 (2023)
Abstract Aims Low levels of homoarginine and creatine are associated with heart failure severity in humans, but it is unclear to what extent they contribute to pathophysiology. Both are synthesized via L‐arginine:glycine amidinotransferase (AGAT),
Externí odkaz:
https://doaj.org/article/691f3e52900d4fff9ed09158b3da5d5c
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels
Externí odkaz:
https://doaj.org/article/94023c0bcce0442ab38a3695e1f0cc4f
Autor:
Margarita Arianoutsou, Ioannis Bazos, Anastasia Christopoulou, Yannis Kokkoris, Andreas Zikos, Sevasti Zervou, Pinelopi Delipetrou, Ana Cristina Cardoso, Ivan Deriu, Eugenio Gervasini, Konstantinos Tsiamis
Publikováno v:
PeerJ, Vol 9, p e11270 (2021)
The Convention on Biological Diversity (CBD) pathways classification framework used in the implementation of the European Union’s (EU) Regulation 1143/2014 on invasive alien species (IAS Regulation) has recently been adopted by the European Alien S
Externí odkaz:
https://doaj.org/article/bd42b3a41f31401bbdb83caffa14e8dd
Autor:
Sevasti Zervou, Debra J. McAndrew, Hannah J. Whittington, Hannah A. Lake, Kyung Chan Park, Kuan Minn Cha, Philip J. Ostrowski, Thomas R. Eykyn, Jürgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
AimsAdenylate kinase 1 (AK1) catalyses the reaction 2ADP ↔ ATP + AMP, extracting extra energy under metabolic stress and promoting energetic homeostasis. We hypothesised that increased AK1 activity would have negligible effects at rest, but protect
Externí odkaz:
https://doaj.org/article/4987ce7164ec4b948b413bb6efbed548
Autor:
Dunja Aksentijević, Sevasti Zervou, Thomas R. Eykyn, Debra J. McAndrew, Julie Wallis, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart
Externí odkaz:
https://doaj.org/article/a17d9c8f7cff4d13bb919761852314e7
Autor:
Sevasti Zervou, Hannah J Whittington, Philip J Ostrowski, Fang Cao, Jack Tyler, Hannah A Lake, Stefan Neubauer, Craig A Lygate
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182994 (2017)
The creatine kinase (CK) phosphagen system is fundamental to cellular energy homeostasis. Cardiomyocytes express three CK isoforms, namely the mitochondrial sarcomeric CKMT2 and the cytoplasmic CKM and CKB. We hypothesized that augmenting CK in vitro
Externí odkaz:
https://doaj.org/article/a4faef99ab7448fd83a6dd79b79440e0
Autor:
Dunja Aksentijević, Sevasti Zervou, Kiterie M E Faller, Debra J McAndrew, Jurgen E Schneider, Stefan Neubauer, Craig A Lygate
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109021 (2014)
Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the
Externí odkaz:
https://doaj.org/article/f1546b6aa1074079ba65d4d5420ba05b
Autor:
Adrian L. Harris, Benedikt M. Kessler, Craig A. Lygate, Sevasti Zervou, Hannah A. Lake, Hannah J. Whittington, Oscar Yanes, Miguel Rodriguez, Dilair Baban, Francesca M. Buffa, Syed Haider, Esther Bridges, Alan McIntyre, Martin Frejno, Roman Fischer, Katharina Feldinger, Tomoyoshi Soga, Patrick K. Albers, Christos E. Zois, Matteo Morotti, Alessandro Valli
S3. HIF1α and hypoxia-dependent effects on transcription and protein levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d37bd4b9cbd85ee8251787d7b3404c
https://doi.org/10.1158/1541-7786.22515507
https://doi.org/10.1158/1541-7786.22515507
Autor:
Adrian L. Harris, Benedikt M. Kessler, Craig A. Lygate, Sevasti Zervou, Hannah A. Lake, Hannah J. Whittington, Oscar Yanes, Miguel Rodriguez, Dilair Baban, Francesca M. Buffa, Syed Haider, Esther Bridges, Alan McIntyre, Martin Frejno, Roman Fischer, Katharina Feldinger, Tomoyoshi Soga, Patrick K. Albers, Christos E. Zois, Matteo Morotti, Alessandro Valli
Supplementary materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c64d0ff63bdf85ae6f0c1526a1b4439
https://doi.org/10.1158/1541-7786.22515486.v1
https://doi.org/10.1158/1541-7786.22515486.v1