Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Seungil Paik"'
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Publikováno v:
Biomedicines, Vol 9, Iss 1, p 27 (2021)
Somatostatin is involved in the regulation of multiple signaling pathways and affords neuroprotection in response to neurotoxins. In the present study, we investigated the role of Somatostatin-14 (SST) in cell viability and the regulation of phosphor
Externí odkaz:
https://doaj.org/article/d7d90fbf570d45af8603cb8c70cb4c38
Autor:
Marco Gallo, Ryan A. Groves, Nicola Pett, Kathy D. McCoy, Seungil Paik, Noah C. A. Cooke, Hena R. Ramay, Kirsty Brown, Ian A. Lewis, Lukas F. Mager, John Stagg, Regula Burkhard, Markus B. Geuking
Publikováno v:
Science. 369:1481-1489
Inosine modulates antitumor immunity Checkpoint blockade immunotherapy harnesses the immune system to kill cancer cells and has been used with great success to treat certain tumors, but not all cancer patients respond. The efficacy of checkpoint bloc
Autor:
Ana Nikolic, Anna Bobyn, Francesca Maule, Katrina Ellestad, Seungil Paik, Sajid Marhon, Parinaz Mehdipour, Xuequng Lun, Michael Johnston, Christopher Gafiuk, Franz Zemp, Yaoqing Shen, Nicoletta Ninkovic, Elodie Labit, N Daniel Berger, Duncan Brownsey, John Kelly, Jeff Biernaskie, Peter Dirks, Darren Derksen, Steven J M Jones, Donna L Senger, Jennifer Chan, Douglas J Mahoney, Daniel de Carvalho, Marco Gallo
Publikováno v:
Neuro-Oncology. 24:vii34-vii34
Glioblastoma is a highly malignant tumour driven by a subset of self-renewing cells termed glioblastoma stem cells. This self-renewal phenotype is largely epigenetically driven, however, the exact epigenetic mechanisms underpinning it are poorly unde
Autor:
Michael Johnston, John J Y Lee, Bo Hu, Ana Nikolic, Audrey Baguette, Seungil Paik, Haifen Chen, Sachin Kumar, Carol Chen, Selin Jessa, Polina Balin, Vernon Fong, Melissa Zwaig, Kulandaimanuvel MichealRaj, Xun Chen, Yanlin Zhang, Srinidhi Varadharajan, Pierre Billon, Nikoleta Juretic, Craig Daniels, Caterina Giannini, Eric Thompson, Peter Hauser, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee, Wieslawa Grajkowska, Sameer Agnihotri, Stephen C Mack, Benjamin Ellezam, Alex Weil, Guillaume Bourque, Jennifer Chan, Mathieu Lupien, Jiannis Ragoussis, Claudia Kleinman, Jacek Majewski, Nada Jabado, Michael Taylor, Mathieu Blanchette, Marco Gallo
Publikováno v:
Neuro-Oncology. 24:vii124-vii124
Posterior Fossa Group A (PFA) ependymomas are pediatric brain tumors with extremely poor survival outcomes. As protein-coding mutations in PFA are exceedingly rare, the underlying etiology of these tumors remains elusive. Elevated CpG island methylat
Publikováno v:
Journal of Molecular Neuroscience. 68:120-134
Somatostatin (SST) is a growth hormone inhibitory peptide involved in regulation of several physiological responses of cells including neurotransmission, cell migration, maturation, and neurite formation. In the present study, we examined the role of
Publikováno v:
Biomedicines
Volume 9
Issue 1
Biomedicines, Vol 9, Iss 27, p 27 (2021)
Volume 9
Issue 1
Biomedicines, Vol 9, Iss 27, p 27 (2021)
Somatostatin is involved in the regulation of multiple signaling pathways and affords neuroprotection in response to neurotoxins. In the present study, we investigated the role of Somatostatin-14 (SST) in cell viability and the regulation of phosphor
Autor:
Kirsty Brown, Noah C. A. Cooke, Hena R. Ramay, John Stagg, Ryan Grooves, Ian A. Lewis, Regula Burkhard, Marco Gallo, Lukas F. Mager, Seungil Paik, Markus B. Geuking, Kathy D. McCoy
SummaryCancer is a leading cause of death globally. Checkpoint blockade therapies offer a promising treatment for many cancers, but have been ineffective for colorectal cancers. Previous studies have shown a dependency of immunotherapies on the micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07350789f3aaea3be032309a2430e4df
https://doi.org/10.1101/2020.02.26.965533
https://doi.org/10.1101/2020.02.26.965533
Publikováno v:
Molecular Neurobiology. 56:292-306
In Alzheimer's disease (AD), the impaired clearance of β-amyloid peptide (Aβ) due to disrupted tight junction and transporter proteins is the prominent cause of disease progression. Somatostatin (SST) blocks the aggregation of Aβ and inflammation
Publikováno v:
Stem Cells and Development. 23:1798-1808
The chondrogenic differentiation process of human mesenchymal stem cells (hMSCs) passes through multiple stages, which are carried out by various factors and their interactions. Recently, microRNAs that regulate chondrogenic differentiation have been