Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Seungil, Han"'
Autor:
David Jonathan Wasilko, Brian S. Gerstenberger, Kathleen A. Farley, Wei Li, Jennifer Alley, Mark E. Schnute, Ray J. Unwalla, Jorge Victorino, Kimberly K. Crouse, Ru Ding, Parag V. Sahasrabudhe, Fabien Vincent, Richard K. Frisbie, Alpay Dermenci, Andrew Flick, Chulho Choi, Gary Chinigo, James J. Mousseau, John I. Trujillo, Philippe Nuhant, Prolay Mondal, Vincent Lombardo, Daniel Lamb, Barbara J. Hogan, Gurdeep Singh Minhas, Elena Segala, Christine Oswald, Ian W. Windsor, Seungil Han, Mathieu Rappas, Robert M. Cooke, Matthew F. Calabrese, Gabriel Berstein, Atli Thorarensen, Huixian Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The CC chemokine receptor 6 (CCR6) is a potential target for chronic inflammatory diseases. Previously, we reported an active CCR6 structure in complex with its cognate chemokine CCL20, revealing the molecular basis of CCR6 activation. Here,
Externí odkaz:
https://doaj.org/article/91af6bd491994266b492f68b0994ea6e
Autor:
Joshua A. Lees, João M. Dias, Francis Rajamohan, Jean-Philippe Fortin, Rebecca O’Connor, Jimmy X. Kong, Emily A. G. Hughes, Ethan L. Fisher, Jamison B. Tuttle, Gabrielle Lovett, Bethany L. Kormos, Rayomand J. Unwalla, Lei Zhang, Anne-Marie Dechert Schmitt, Dahui Zhou, Michael Moran, Kimberly A. Stevens, Kimberly F. Fennell, Alison E. Varghese, Andrew Maxwell, Emmaline E. Cote, Yuan Zhang, Seungil Han
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract GPR61 is an orphan GPCR related to biogenic amine receptors. Its association with phenotypes relating to appetite makes it of interest as a druggable target to treat disorders of metabolism and body weight, such as obesity and cachexia. To d
Externí odkaz:
https://doaj.org/article/5d8246b6d9824727b8ad761786a5eac1
Autor:
João Conde, Ruth A. Pumroy, Charlotte Baker, Tiago Rodrigues, Ana Guerreiro, Bárbara B. Sousa, Marta C. Marques, Bernardo P. de Almeida, Sohyon Lee, Elvira P. Leites, Daniel Picard, Amrita Samanta, Sandra H. Vaz, Florian Sieglitz, Maike Langini, Marc Remke, Rafael Roque, Tobias Weiss, Michael Weller, Yuhang Liu, Seungil Han, Francisco Corzana, Vanessa A. Morais, Cláudia C. Faria, Tânia Carvalho, Panagis Filippakopoulos, Berend Snijder, Nuno L. Barbosa-Morais, Vera Y. Moiseenkova-Bell, Gonçalo J. L. Bernardes
Publikováno v:
ACS Central Science, Vol 7, Iss 5, Pp 868-881 (2021)
Externí odkaz:
https://doaj.org/article/13e41edb1f1f40069a060c39b209935b
Autor:
Francis Rajamohan, Allan R. Reyes, Meihua Tu, Nicole L. Nedoma, Lise R. Hoth, Adam G. Schwaid, Ravi G. Kurumbail, Jessica Ward, Seungil Han
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 8, Pp 1192-1202 (2020)
Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs a
Externí odkaz:
https://doaj.org/article/84d1fdf5b7d8464b8ffe5b0c44285c5e
Autor:
David Jonathan Wasilko, Zachary Lee Johnson, Mark Ammirati, Ye Che, Matthew C. Griffor, Seungil Han, Huixian Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Chemokine receptors are GPCRs involved in immune responses and regulated by small protein ligands known as chemokines. A structural study of the human CCR6/CCL20–Go complex reveals that CCL20 binds in a shallow extracellular pocket, and suggests th
Externí odkaz:
https://doaj.org/article/563862bc1d384d9c84f3cca32e285ede
Autor:
Somnath Mukherjee, Satchal K. Erramilli, Mark Ammirati, Frances J. D. Alvarez, Kimberly F. Fennell, Michael D. Purdy, Blazej M. Skrobek, Katarzyna Radziwon, John Coukos, Yanyong Kang, Przemysław Dutka, Xiang Gao, Xiayang Qiu, Mark Yeager, H. Eric Xu, Seungil Han, Anthony A. Kossiakoff
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Single particle cryo-electron microscopy of membrane proteins is limited by their small size and difficulty to orient. Here the authors generate recombinant antibodies against the 12 kDa fusion partner BRIL domain from apocytochrome b562 to use them
Externí odkaz:
https://doaj.org/article/c4e601bd5c28456ba07689558d4667e5
Autor:
Nicholas G. Fox, Xiaodi Yu, Xidong Feng, Henry J. Bailey, Alain Martelli, Joseph F. Nabhan, Claire Strain-Damerell, Christine Bulawa, Wyatt W. Yue, Seungil Han
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich’s ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM structure of the human frataxin bound ISC complex and discuss
Externí odkaz:
https://doaj.org/article/8abcf6459af9457bb7545657bbc6ed8d
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40abbd054f7e4f0b7d37c1f6aa452bc0
https://doi.org/10.1038/s41594-022-00884-7
https://doi.org/10.1038/s41594-022-00884-7
Autor:
Benjamin Orris, Kevin W. Huynh, Mark Ammirati, Seungil Han, Ben Bolaños, Jason Carmody, Matthew D. Petroski, Benedikt Bosbach, David J. Shields, James T. Stivers
Publikováno v:
Nucleic Acids Research. 50:7545-7559
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1) is driven into its activated tetramer form by binding of GTP activator and dNTP activators/substrates. In addition, the inactive monomeric and dimeric forms of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b94213327a9411effec66bd325d4c2
https://doi.org/10.1093/nar/gkac573
https://doi.org/10.1093/nar/gkac573
Autor:
Thomas J. McCorvie, Paula M. Loria, Meihua Tu, Seungil Han, Leela Shrestha, D. Sean Froese, Igor M. Ferreira, Allison P. Berg, Wyatt W. Yue
Publikováno v:
Nature Structural & Molecular Biology. 29:628-638
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc44bb43ecd90e99ea2a1aab3f1fa3dc
https://doi.org/10.1038/s41594-022-00799-3
https://doi.org/10.1038/s41594-022-00799-3