Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Seungbeom Lee"'
Autor:
Hyun Su Kim, Hyejin Kong, Taewoo Kim, Changjin Lim, Seungbeom Lee, Seok-Ho Kim, Young-Ger Suh
Publikováno v:
Marine Drugs, Vol 21, Iss 5, p 281 (2023)
This study aimed to elucidate the structural congeners of natural izenamides A, B, and C (1–3) responsible for cathepsin D (CTSD) inhibition. Structurally modified izenamides were synthesized and biologically evaluated, and their biologically impor
Externí odkaz:
https://doaj.org/article/3d0321274dbe4b529d34a2e1c2d6eb62
Autor:
Eun Ji Lee, Su-Jung Kim, Young-Il Hahn, Hyo-Jin Yoon, Bitnara Han, Kyeojin Kim, Seungbeom Lee, Kwang Pyo Kim, Young Ger Suh, Hye-Kyung Na, Young-Joon Surh
Publikováno v:
Redox Biology, Vol 23, Iss , Pp - (2019)
Overproduction of prostaglandin E2 (PGE2) has been linked to enhanced tumor cell proliferation, invasiveness and metastasis as well as resistance to apoptosis. 15-Keto prostaglandin E2 (15-keto PGE2), a product formed from 15-hydroxyprostaglandin deh
Externí odkaz:
https://doaj.org/article/1ad8036ce9ce4c94926980e813acbf27
Autor:
Sung-Jun Hong, Jin-Tae Kim, Su-Jung Kim, Nam-Chul Cho, Kyeojin Kim, Seungbeom Lee, Young-Ger Suh, Kyung-Cho Cho, Kwang Pyo Kim, Young-Joon Surh
Publikováno v:
Biomedicines, Vol 8, Iss 10, p 407 (2020)
Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment. P
Externí odkaz:
https://doaj.org/article/bbb95ad43b9546b39e7dfc92f9aa53c4
Autor:
Yoo-Seong Jeong, Minjeong Baek, Seungbeom Lee, Min-Soo Kim, Han-Joo Maeng, Jong-Hwa Lee, Young-Ger Suh, Suk-Jae Chung
Publikováno v:
Molecules, Vol 25, Iss 3, p 531 (2020)
SH-1242, a novel inhibitor of heat shock protein 90 (HSP90), is a synthetic analog of deguelin: It was previously reported that the treatment of SH-1242 led to a strong suppression of hypoxia-mediated retinal neovascularization and vascular leakage i
Externí odkaz:
https://doaj.org/article/5b77a322096042fcac79fbeafb562010
Publikováno v:
Journal of Flexible and Printed Electronics. 1:155-173
Organic photonic synapses are promising candidates for optoelectronic neuromorphic electronic components owing to their advantages from both material and signal perspectives. Organic materials have advantages such as low cost, tunable properties acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58d47b1eb909c4abf9cd04eb373ef0db
https://doi.org/10.56767/jfpe.2022.1.2.155
https://doi.org/10.56767/jfpe.2022.1.2.155
Autor:
Yeonjin Ko, Mannkyu Hong, Seungbeom Lee, Manoj Kumar, Lara Ibrahim, Kayla Nutsch, Caroline Stanton, Phillip Sondermann, Braddock Sandoval, Maya L. Bulos, Jonathan Iaconelli, Arnab K. Chatterjee, R. Luke Wiseman, Peter G. Schultz, Michael J. Bollong
Publikováno v:
Proceedings of the National Academy of Sciences. 120
KEAP1 (Kelch-like ECH-associated protein), a cytoplasmic repressor of the oxidative stress responsive transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), senses the presence of electrophilic agents by modification of its sensor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9942402c6cf77a38e8f7f6272daca91
https://doi.org/10.1073/pnas.2300763120
https://doi.org/10.1073/pnas.2300763120
Autor:
Ho-Young Lee, Young-Ger Suh, Kyu-Won Kim, Jeeyeon Lee, Jeewoo Lee, Sang Kook Lee, Hyun-Ju Park, Young-Myeong Kim, Seungbeom Lee, Ji Hae Seo, So-Jung Park, Hongchan An, Jun Yong Kim, Shin-Hyung Park, Jayoung Moon, Ho Jin Lee, Seung Yeob Hyun, Kwan Hee Park, Song Yi Bae, Hoon Choi, Hye-Young Min, Su-Chan Lee
The Hsp90 facilitates proper folding of signaling proteins associated with cancer progression, gaining attention as a target for therapeutic intervention. The natural rotenoid deguelin was identified as an Hsp90 inhibitor, but concerns about neurotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cf21b9cbbd20ce0df81b4685ebc1e
https://doi.org/10.1158/0008-5472.c.6507899.v1
https://doi.org/10.1158/0008-5472.c.6507899.v1
Autor:
Ho-Young Lee, Young-Ger Suh, Kyu-Won Kim, Jeeyeon Lee, Jeewoo Lee, Sang Kook Lee, Hyun-Ju Park, Young-Myeong Kim, Seungbeom Lee, Ji Hae Seo, So-Jung Park, Hongchan An, Jun Yong Kim, Shin-Hyung Park, Jayoung Moon, Ho Jin Lee, Seung Yeob Hyun, Kwan Hee Park, Song Yi Bae, Hoon Choi, Hye-Young Min, Su-Chan Lee
Supplementary Materials and Methods. Supplementary Table 1. The acquisition of drug resistance in several drug resistant cells (designated '/R') upon corresponding anticancer drug treatment. Supplementary Table 2. Docking and scoring known Hsp90 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bcadca4faf4c3e3dc953862a8eaa1a2
https://doi.org/10.1158/0008-5472.22410032
https://doi.org/10.1158/0008-5472.22410032
Publikováno v:
Journal of Institute of Control, Robotics and Systems. 27:177-184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53b9707a82bde5c6d9613bef4764241
https://doi.org/10.5302/j.icros.2021.20.0187
https://doi.org/10.5302/j.icros.2021.20.0187
Autor:
Young-Ger Suh, Seungbeom Lee, Jaehoon Sim, Changjin Lim, Hyun Jin Choi, Hyunkyung Park, Juhee Lim, Tae Woo Kim, Joonseong Hur, Hyun Su Kim
Publikováno v:
The Journal of Organic Chemistry. 85:13779-13792
A collective synthetic route for tricyclic guaiane sesquiterpenes and total syntheses of (+)-dysodensiol F, (+)-10β,14-dihydroxy-allo-aromadendrane, and (-)-dendroside C aglycon starting from a versatile hydroazulene intermediate were accomplished.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a1d90489ca004b35ee6dc3bbb84a5ce
https://doi.org/10.1021/acs.joc.0c01907
https://doi.org/10.1021/acs.joc.0c01907