Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Seung-Rock Lee"'
Autor:
Gulzar Ahmed Rather, Preethi Selvakumar, K. Satish Srinivas, K. Natarajan, Ajeet Kaushik, Prabhakar Rajan, Seung-Rock Lee, Wong Ling Sing, Mohammad Alkhamees, Sen Lian, Merrel Holley, Young Do Jung, Vinoth-Kumar Lakshmanan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Nanogels offer hope for precise drug delivery, while addressing drug delivery hurdles is vital for effective prostate cancer (PCa) management. We developed an injectable elastin nanogels (ENG) for efficient drug delivery system to overcome c
Externí odkaz:
https://doaj.org/article/f93da2ad097e4ba082b704b0360f6687
Autor:
Vu Hoang Trinh, Jin-Myung Choi, Thang Nguyen Huu, Dhiraj Kumar Sah, Hyun-Joong Yoon, Sang-Chul Park, Yu-Seok Jung, Young-Keun Ahn, Kun-Ho Lee, Seung-Rock Lee
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 473 (2024)
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphoinositide 3-kinases/protein kinase B (PI3K/AKT) signaling pathway. Notably, its active site contains a cysteine residue that is susceptible to oxidation by hydrogen peroxide
Externí odkaz:
https://doaj.org/article/c487b5d5743d480c87dcf61e5f2fc3f0
Autor:
Vu Hoang Trinh, Thang Nguyen Huu, Dhiraj Kumar Sah, Jin Myung Choi, Hyun Joong Yoon, Sang Chul Park, Yu Seok Jung, Seung-Rock Lee
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 199 (2024)
Phosphatase and tensin homolog (PTEN) is a tumor suppressor due to its ability to regulate cell survival, growth, and proliferation by downregulating the PI3K/AKT signaling pathway. In addition, PTEN plays an essential role in other physiological eve
Externí odkaz:
https://doaj.org/article/a386715cdc944391ab507012a41d7459
Autor:
Thang Nguyen Huu, Jiyoung Park, Ying Zhang, Hien Duong Thanh, Iha Park, Jin Myung Choi, Hyun Joong Yoon, Sang Chul Park, Hyun Ae Woo, Seung-Rock Lee
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 120 (2023)
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are becoming increasingly prevalent worldwide. Despite the different etiologies, their spectra and histological feature are similar, from simple steatosis to more advanced sta
Externí odkaz:
https://doaj.org/article/025cbbd8e7d9466caca3d23ca7ec9bc2
Autor:
Ying Zhang, Jiyoung Park, Seong-Jeong Han, Sung Yeul Yang, Hyun Joong Yoon, Iha Park, Hyun Ae Woo, Seung-Rock Lee
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101553- (2020)
Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) is a potent tumor suppressor and often dysregulated in cancers. Cellular PTEN activity is restrained by the oxidation of active-site cysteine by reactive oxygen species (ROS). Recovery o
Externí odkaz:
https://doaj.org/article/01cadad6f37a4119bd5568631d222c5a
Autor:
Thang Nguyen Huu, Jiyoung Park, Ying Zhang, Iha Park, Hyun Joong Yoon, Hyun Ae Woo, Seung-Rock Lee
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 302 (2021)
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes. PTEN functions as a negative regulator of PI3K/Akt signaling pathway by d
Externí odkaz:
https://doaj.org/article/dd30c3ea92984d1ab293d144c67f192a
Autor:
Ying Zhang, Yeon Jin Roh, Seong-Jeong Han, Iha Park, Hae Min Lee, Yong Sik Ok, Byung Cheon Lee, Seung-Rock Lee
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 383 (2020)
Selenium is a vital trace element present as selenocysteine (Sec) in proteins that are, thus, known as selenoproteins. Humans have 25 selenoproteins, most of which are functionally characterized as oxidoreductases, where the Sec residue plays a catal
Externí odkaz:
https://doaj.org/article/794d8e066f854e0abbf7f3ce770af05d
Autor:
Ying Zhang, Seong-Jeong Han, Iha Park, Inyoung Kim, Kee-Oh Chay, Seok Mo Kim, Dong Il Jang, Tae-Hoon Lee, Seung-Rock Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 5, p 982 (2017)
Organic peroxides and hydroperoxides are skin tumor promoters. Free radical derivatives from these compounds are presumed to be the prominent mediators of tumor promotion. However, the molecular targets of these species are unknown. Phosphatase and t
Externí odkaz:
https://doaj.org/article/3817b8eb84be4b0facc43d9b5b9c37e3
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95518 (2014)
Selenoproteins exhibit diverse biological functions, most of which are associated with redox control. However, the functions of approximately half of mammalian selenoproteins are not known. One such protein is Selenoprotein O (SelO), the largest mamm
Externí odkaz:
https://doaj.org/article/3b058a4a770747d990fc31fa420f5d70
Autor:
Iha Park, Jiyoung Park, Jong Suk Kim, Ying Zhang, Hyun Ae Woo, Seung-Rock Lee, Seong Jeong Han, Thang Nguyen Huu
Publikováno v:
Free Radical Biology and Medicine. 162:141-148
Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d027fdf599c6e9d897c4453ab0e82d61
https://doi.org/10.1016/j.freeradbiomed.2020.11.022
https://doi.org/10.1016/j.freeradbiomed.2020.11.022