Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Seung Uk Oh"'
Autor:
Seung Uk Oh, Kristin L.M. Boylan, Amy P.N. Skubitz, Elizabeth Taras, Angela Panoskaltsis-Mortari, Nate N. Waldron, Daniel A. Vallera
Publikováno v:
Gynecologic Oncology. 130:579-587
While most women with ovarian cancer will achieve complete remission after treatment, the majority will relapse within two years, highlighting the need for novel therapies. Cancer stem cells (CSC) have been identified in ovarian cancer and most other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3601a609e4b8a3ab212de3baf1f190
https://doi.org/10.1016/j.ygyno.2013.05.027
https://doi.org/10.1016/j.ygyno.2013.05.027
Autor:
Dan S. Kaufman, Seung Uk Oh, Michael R. Verneris, Daniel A. Vallera, Michelle K. Gleason, Bin Zhang, Jeffrey S. Miller, Valarie McCullar, Louis M. Weiner
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 28:274-282
A heterodimeric bispecific biological recombinant drug was synthesized by splicing DNA fragments from two fully humanized single-chain variable-fragment (scFV) antibody fragments forming a novel drug simultaneously recognizing the CD16 natural killer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824c97f58c76378eb0ee70bb97c5b270
https://doi.org/10.1089/cbr.2012.1329
https://doi.org/10.1089/cbr.2012.1329
Autor:
Nate N. Waldron, Shoko Toma, David M. Zellmer, John R. Ohlfest, Seung Uk Oh, Daniel A. Vallera, Suresh Kumar Swaminathan, Jayanth Panyam
Publikováno v:
Drug Delivery and Translational Research. 3:195-204
CD133 expression enriches for tumor-initiating cells and is a negative prognostic factor in numerous cancers. We previously developed an immunotoxin against CD133 by fusing a gene fragment encoding the scFv portion of an anti-CD133 antibody to a gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c597015f81613522922e55b0cc4ae0c
https://doi.org/10.1007/s13346-012-0066-2
https://doi.org/10.1007/s13346-012-0066-2
Autor:
Daniel A. Vallera, Seung Uk Oh, John R. Ohlfest, Zintis Inde, Dan S. Kaufman, Nate N. Waldron, Melinda K. Hexum
Publikováno v:
Molecular Cancer Therapeutics. 10:1829-1838
A novel anticancer agent was constructed by fusing a gene encoding the scFV that targets both glycosylated and unglycosylated forms of CD133 to a gene fragment encoding deimmunized PE38KDEL. The resulting fusion protein, dCD133KDEL, was studied to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a84b657fb66f8d995798c55584c798
https://doi.org/10.1158/1535-7163.mct-11-0206
https://doi.org/10.1158/1535-7163.mct-11-0206
Autor:
Seung Uk Oh, John R. Ohlfest, Alexander K. Tsai, Daniel A. Vallera, Angela Panoskaltsis-Mortari
Publikováno v:
Journal of Neurosurgery. 114:1662-1671
Object The authors of this study aimed to genetically design a bispecific targeted toxin that would simultaneously target overexpressed markers on glioma as well as the tumor vasculature, to mutate certain amino acids to reduce the immunogenicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0eacf2d55d022d1174c88332f8452d2
https://doi.org/10.3171/2010.11.jns101214
https://doi.org/10.3171/2010.11.jns101214
Publikováno v:
Clinical Cancer Research. 15:6137-6147
Purpose: To develop a targeted biological drug that when systemically injected can penetrate to metastatic breast cancer tumors, one needs a drug of high potency and reduced immunogenicity. Thus, we bioengineered a novel bispecific ligand–directed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8250b0dd88a488d281a580b713453afd
https://doi.org/10.1158/1078-0432.ccr-09-0696
https://doi.org/10.1158/1078-0432.ccr-09-0696
Autor:
Robert A. Kratzke, Arkadiusz Z. Dudek, Hua Chen, Daniel A. Vallera, Bradley J. Stish, Seung Uk Oh
Publikováno v:
British Journal of Cancer
Background: Potency, immunogenicity, and toxicity are three problems that limit the use of targeted toxins in solid tumour therapy. Methods: To address potency, we used genetic engineering to develop a novel bispecific ligand-directed toxin (BLT) cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39ed2bf929f7ec0079b7925c9c09df0
https://doi.org/10.1038/sj.bjc.6605297
https://doi.org/10.1038/sj.bjc.6605297
Autor:
Soheila Gharagozlou, Walter C. Low, Raji N. Vedi, Katya Ericson, Anhua Wu, John R. Ohlfest, Wei Chen, Seung Uk Oh
Publikováno v:
Journal of Immunotherapy. 30:789-797
Dendritic cell (DC) vaccines have shown antitumor activity in experimental glioma models and in human glioma patients. The typical approach has been to generate the vaccine ex vivo, by pulsing DCs with tumor lysate or peptides, then administering the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223b703570cabadfeaf2a77695e21470
https://doi.org/10.1097/cji.0b013e318155a0f6
https://doi.org/10.1097/cji.0b013e318155a0f6
Publikováno v:
The KIPS Transactions:PartD. :675-688
Memory access errors are frequently occurred in C programs. A number of tools and research works have been trying to detect the errors automatically. However, they have one or more of the following problems: inability to detect all memory errors, cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4827db64f7e127efd671eecb17ca8646
https://doi.org/10.3745/kipstd.2007.14-d.6.675
https://doi.org/10.3745/kipstd.2007.14-d.6.675