Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Seung K Kim"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010619 (2023)
Insulin regulation is a hallmark of health, and impaired insulin signaling promotes metabolic diseases like diabetes mellitus. However, current assays for measuring insulin signaling in all animals remain semi-quantitative and lack the sensitivity, t
Externí odkaz:
https://doaj.org/article/803122a622954d4d938c00c1f33bf286
Autor:
Leah A Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y Lam, James Lyon, Jocelyn E Manning Fox, Locksley E McGann, Patrick E MacDonald, Seung K Kim, Janet A W Elliott
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0263005 (2022)
The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell transcriptome studies on the pathology and treatment of diabetes. Using an iterative graded freezin
Externí odkaz:
https://doaj.org/article/fad37b192bdd41d78f2f22a3a92ae661
Autor:
Christina S Chao, Kristen D McKnight, Kenneth L Cox, Anne L Chang, Seung K Kim, Brian J Feldman
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118449 (2015)
Patients with pancreatic agenesis are born without a pancreas, causing permanent neonatal diabetes and pancreatic enzyme insufficiency. These patients require insulin and enzyme replacement therapy to survive, grow, and maintain normal blood glucose
Externí odkaz:
https://doaj.org/article/4cea7d86148a4d76857c4ae2e8ba05b2
Autor:
Cecil M Benitez, Kun Qu, Takuya Sugiyama, Philip T Pauerstein, Yinghua Liu, Jennifer Tsai, Xueying Gu, Amar Ghodasara, H Efsun Arda, Jiajing Zhang, Joseph D Dekker, Haley O Tucker, Howard Y Chang, Seung K Kim
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004645 (2014)
The regulatory logic underlying global transcriptional programs controlling development of visceral organs like the pancreas remains undiscovered. Here, we profiled gene expression in 12 purified populations of fetal and adult pancreatic epithelial c
Externí odkaz:
https://doaj.org/article/012a70afd9b449a890f49665fe50730b
Publikováno v:
PLoS Genetics, Vol 10, Iss 8, p e1004555 (2014)
Insulin is a major regulator of metabolism in metazoans, including the fruit fly Drosophila melanogaster. Genome-wide association studies (GWAS) suggest a genetic basis for reductions of both insulin sensitivity and insulin secretion, phenotypes comm
Externí odkaz:
https://doaj.org/article/9db76ed3e3f5413db4f5bd9a77aab87f
Autor:
Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of Tregs is being clinically evaluated as a novel way to prevent or tr
Externí odkaz:
https://doaj.org/article/9eb5d3e2468049a48285a66700ca2b17
Autor:
Insung Park, Sergio Navarro-Serna, Raquel M. Pinho, Trish Berger, Elizabeth A. Maga, Joaqu?n Gadea, Seung K. Kim, Pablo J. Ross
Publikováno v:
Re:GEN Open, Vol 4, Iss 1, Pp 9-20 (2024)
Introduction: CRISPR/Cas9-mediated editing of embryos through microinjection is limited in efficiency because of high rates of mosaicism and off-target mutations. Electroporation has been proposed as an easier and faster procedure compared to single
Externí odkaz:
https://doaj.org/article/ca79aef459f941d493f6c8f1535e9b85
Autor:
Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L Szot, Rita Bottino, Seung K Kim
Publikováno v:
eLife, Vol 2 (2013)
Pancreatic islet β-cell insufficiency underlies pathogenesis of diabetes mellitus; thus, functional β-cell replacement from renewable sources is the focus of intensive worldwide effort. However, in vitro production of progeny that secrete insulin i
Externí odkaz:
https://doaj.org/article/d31f04dfd2b2453cadeb139439e5ffdf
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002241 (2011)
Drosophila neuroendocrine cells comprising the corpora cardiaca (CC) are essential for systemic glucose regulation and represent functional orthologues of vertebrate pancreatic α-cells. Although Drosophila CC cells have been regarded as developmenta
Externí odkaz:
https://doaj.org/article/0828595f56c040b68d87e5b285a512f3
Autor:
Nora G Smart, Asa A Apelqvist, Xueying Gu, Erin B Harmon, James N Topper, Raymond J MacDonald, Seung K Kim
Publikováno v:
PLoS Biology, Vol 4, Iss 2, p e39 (2006)
Identification of signaling pathways that maintain and promote adult pancreatic islet functions will accelerate our understanding of organogenesis and improve strategies for treating diseases like diabetes mellitus. Previous work has implicated trans
Externí odkaz:
https://doaj.org/article/a25af382823c4d3992b9b9f2697df956