Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Seung K, Kim"'
Autor:
Xiangni Wu, Pin-I Chen, Robert L. Whitener, Matthew S. MacDougall, Vy M. N. Coykendall, Hao Yan, Yong Bin Kim, William Harper, Shiva Pathak, Bettina P. Iliopoulou, Allison Hestor, Diane C. Saunders, Erick Spears, Jean Sévigny, David M. Maahs, Marina Basina, Seth A. Sharp, Anna L. Gloyn, Alvin C. Powers, Seung K. Kim, Kent P. Jensen, Everett H. Meyer
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Human regulatory T cells (Treg) suppress other immune cells. Their dysfunction contributes to the pathophysiology of autoimmune diseases, including type 1 diabetes (T1D). Infusion of Tregs is being clinically evaluated as a novel way to prevent or tr
Externí odkaz:
https://doaj.org/article/9eb5d3e2468049a48285a66700ca2b17
Autor:
Insung Park, Sergio Navarro-Serna, Raquel M. Pinho, Trish Berger, Elizabeth A. Maga, Joaqu?n Gadea, Seung K. Kim, Pablo J. Ross
Publikováno v:
Re:GEN Open, Vol 4, Iss 1, Pp 9-20 (2024)
Introduction: CRISPR/Cas9-mediated editing of embryos through microinjection is limited in efficiency because of high rates of mosaicism and off-target mutations. Electroporation has been proposed as an easier and faster procedure compared to single
Externí odkaz:
https://doaj.org/article/ca79aef459f941d493f6c8f1535e9b85
Autor:
Romina J. Bevacqua, Weichen Zhao, Emilio Merheb, Seung Hyun Kim, Alexander Marson, Anna L. Gloyn, Seung K. Kim
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108693- (2024)
Summary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here, we describe a CRISPR-based strategy to interrogate functions of predicted regula
Externí odkaz:
https://doaj.org/article/de99b45ae5104da68c614e2231a5ccff
Autor:
Preksha Bhagchandani, Charles A. Chang, Weichen Zhao, Luiza Ghila, Pedro L. Herrera, Simona Chera, Seung K. Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Improved models of experimental diabetes are needed to develop cell therapies for diabetes. Here, we introduce the B6 RIP-DTR mouse, a model of experimental diabetes in fully immunocompetent animals. These inbred mice harbor the H2b major hi
Externí odkaz:
https://doaj.org/article/9f14e82940fb47cfa087063f5419f40c
Autor:
Franz Wendler, Sangbin Park, Claire Hill, Alessia Galasso, Kathleen R. Chang, Iman Awan, Yulia Sudarikova, Mar Bustamante-Sequeiros, Sichen Liu, Ethan Y-H. Sung, Gabrielle Aisa-Bonoko, Seung K. Kim, Luis A. Baena-Lopez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The existence of three independent binary systems for conditional gene expression (Gal4/UAS; LexA/LexAop; QF/QUAS) has greatly expanded versatile genetic analyses in the Drosophila melanogaster; however, the experimental application of these
Externí odkaz:
https://doaj.org/article/a91039c0a3d9432285cd75cd7cd85a5c
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010619 (2023)
Insulin regulation is a hallmark of health, and impaired insulin signaling promotes metabolic diseases like diabetes mellitus. However, current assays for measuring insulin signaling in all animals remain semi-quantitative and lack the sensitivity, t
Externí odkaz:
https://doaj.org/article/803122a622954d4d938c00c1f33bf286
Autor:
Romina J. Bevacqua, Xiaoqing Dai, Jonathan Y. Lam, Xueying Gu, Mollie S. H. Friedlander, Krissie Tellez, Irene Miguel-Escalada, Silvia Bonàs-Guarch, Goutham Atla, Weichen Zhao, Seung Hyun Kim, Antonia A. Dominguez, Lei S. Qi, Jorge Ferrer, Patrick E. MacDonald, Seung K. Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The editing of primary human islets could provide insight into diabetes pathogenesis. Here the authors use CRISPR-Cas9 to target regulatory elements associated with T2D susceptibility.
Externí odkaz:
https://doaj.org/article/22d2b0339efc4aa29c30bb51db113c85
Autor:
Leah A. Marquez-Curtis, Xiao-Qing Dai, Yan Hang, Jonathan Y. Lam, James Lyon, Jocelyn E. Manning Fox, Locksley E. McGann, Patrick E. MacDonald, Seung K. Kim, Janet A. W. Elliott
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell transcriptome studies on the pathology and treatment of diabetes. Using an iterative graded freezin
Externí odkaz:
https://doaj.org/article/81bf17f84f3a48baaaa02563801b21a1
Autor:
Klaus H. Kaestner, Martha Campbell–Thompson, Yuval Dor, Ronald G. Gill, Benjamin Glaser, Seung K. Kim, Maike Sander, Cherie Stabler, Andrew F. Stewart, Alvin C. Powers
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101323- (2021)
Background: The pancreatic β cell, as the sole source of the vital hormone insulin, has been under intensive study for more than a century. Given the potential of newly created insulin-producing cells as a treatment or even cure of type 1 diabetes (
Externí odkaz:
https://doaj.org/article/176e01f999a345899f3c242dc7786c64
Autor:
Divya P. Menon, Guanming Qi, Seung K. Kim, M. Elizabeth Moss, Krishna C. Penumatsa, Rod R. Warburton, Deniz Toksoz, Jamie Wilson, Nicholas S. Hill, Iris Z. Jaffe, Ioana R. Preston
Publikováno v:
Pulmonary Circulation, Vol 11 (2021)
Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells. Aldosterone levels are elevated in human pulmonary arterial hypertension and i
Externí odkaz:
https://doaj.org/article/3bd289a1759d4c7eab24592dde2d3cab