Zobrazeno 1 - 10
of 419
pro vyhledávání: '"Seung Bum Park"'
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Pyridine, an essential structure in drug development, shows a wide array of bioactivities according to its substitution patterns. Among the bioactive pyridines, meta-substituted pyridines suffer from limited synthetic approaches despite thei
Externí odkaz:
https://doaj.org/article/c200358934954a0a82b88589d24cb7e8
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Substituted pyridines with diverse functional groups are important structural motifs found in numerous bioactive molecules. Several methodologies for the introduction of various bio-relevant functional groups to pyridine have been reported,
Externí odkaz:
https://doaj.org/article/69eb9754d4a94d8ba941bdeab5831a89
Autor:
Seung Bum Park, Mohsin Khan, Sai Chaitanya Chiliveri, Xin Hu, Parker Irvin, Madeleine Leek, Ailis Grieshaber, Zongyi Hu, Eun Sun Jang, Ad Bax, T. Jake Liang
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Since the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more easily transmitted compared to the earlier Wuhan and the other variants. In this study, we a
Externí odkaz:
https://doaj.org/article/91540e85d7364d0480d15dc87697cdce
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The small molecule SB2301 activates lipophagy and alters lipid droplet membrane composition, with the ethanolamine-phosphate cytidylyltransferase 2 (PCYT2) being a potential target of the compound.
Externí odkaz:
https://doaj.org/article/b18d6cc8a1d148f984215c880c11d03d
Autor:
Seung Bum Park, Takuro Uchida, Samantha Tilson, Zongyi Hu, Christopher D. Ma, Madeleine Leek, Michael Eichner, So Gun Hong, T. Jake Liang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 656-669 (2022)
The CRISPR-Cas9 system has emerged as a powerful and efficient tool for genome editing. An important drawback of the CRISPR-Cas9 system is the constitutive endonuclease activity when Cas9 endonuclease and its sgRNA are co-expressed. This constitutive
Externí odkaz:
https://doaj.org/article/00a6b3d2302c442a9d0074954e895b9b
Autor:
Takuro Uchida, Seung Bum Park, Tadashi Inuzuka, Min Zhang, Joselyn N. Allen, Kazuaki Chayama, T. Jake Liang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 597-605 (2021)
The sodium-dependent taurocholate co-transporting polypeptide (NTCP)-S267F variant is known to be associated with a reduced risk of hepatitis B virus (HBV) infection and disease progression. The NTCP-S267F variant displays diminished function in medi
Externí odkaz:
https://doaj.org/article/6da94754d7634c86bd34d99931061100
Autor:
Jaeyoung Ha, Seung Bum Park
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
In order to elucidate how callyspongiolide, a potent cytotoxic marine natural product, kills human lung cancer cells, Ha and Park employed TS-FITGE technique, a label-free target identification method with thermal stability-shift-based fluorescence d
Externí odkaz:
https://doaj.org/article/21861e7f52244f70ac8f9eb09ea4dba8
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The rigidity and flexibility of small molecules are complementary in 3-dimensional ligand-protein interaction. Therefore, the chemical library with conformational diversity would be a valuable resource for investigating the influence of skeletal flex
Externí odkaz:
https://doaj.org/article/c3a6bbf6419d45cfbba4cf1d11e89aa8
Autor:
Junhyeong Yim, Seung Bum Park
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Elucidation of the molecular mechanism of therapeutic agents and potential candidates is in high demand. Interestingly, rhenium-based complexes have shown a highly selective anticancer effect, only on cancer cells, unlike platinum-based drugs, such a
Externí odkaz:
https://doaj.org/article/19733eedb3034c41b8f3b2093d5edb51
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Vitamin B3 derivatives display a range of biological activities. Here, the authors report the synthesis of meta-aminoaryl nicotinates, derivatives of vitamin B3, and their late-stage conjugation with (hetero)arylamines, ultimately expanding the chemi
Externí odkaz:
https://doaj.org/article/d90d781d2ec1448b8bf09971a769738f