Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Seung Hahm"'
Autor:
Sophie St-Cyr, Daniel D Child, Emilie Giaime, Alicia R Smith, Christine J Pascua, Seung Hahm, Eddine Saiah, Beverly L Davidson
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273710 (2022)
Huntington's Disease (HD) is a dominantly inherited neurodegenerative disease for which the major causes of mortality are neurodegeneration-associated aspiration pneumonia followed by cardiac failure. mTORC1 pathway perturbations are present in HD mo
Externí odkaz:
https://doaj.org/article/5daa31f88c0a405a978f93c37b33aa4c
Autor:
Mylène Perreault, Guo Feng, Sarah Will, Tiffany Gareski, David Kubasiak, Kimberly Marquette, Yulia Vugmeyster, Thaddeus J Unger, Juli Jones, Ariful Qadri, Seung Hahm, Ying Sun, Cynthia M Rohde, Raphael Zwijnenberg, Janet Paulsen, Ruth E Gimeno
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62616 (2013)
Strong genetic data link the Tyrosine kinase receptor B (TrkB) and its major endogenous ligand brain-derived neurotrophic factor (BDNF) to the regulation of energy homeostasis, with loss-of-function mutations in either gene causing severe obesity in
Externí odkaz:
https://doaj.org/article/481f31aa9a094746a20e090fe8fa9248
Autor:
Catharine H. Duman, George P. Vlasuk, Taro Kato, Santosh Pothula, Rong-Jian Liu, Eddine Saiah, Seung Hahm, Ronald S. Duman, Rosemarie Terwilliger
Publikováno v:
J Clin Invest
Preclinical studies demonstrate that rapid-acting antidepressants, including ketamine, require stimulation of mTORC1 signaling. This pathway is regulated by neuronal activity and endocrine and metabolic signals, notably including the amino acid leuci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc335f8b180901f671e2f0efb2f1c7
https://europepmc.org/articles/PMC6546461/
https://europepmc.org/articles/PMC6546461/
Autor:
Emilie Giaime, George P. Vlasuk, Jessica J. Howell, Shomit Sengupta, Seung Hahm, David John O'neill, Eddine Saiah, Sridhar Narayan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1
Autor:
Eddine Saiah, George P. Vlasuk, Seong A. Kang, Stephanie N. Galda, Shomit Sengupta, Jessica J. Howell, Lisa Molz, David John O'neill, Sarah J. Mahoney, Andreas W. Machl, Seung Hahm, Casey J. Lumpkin
Publikováno v:
Cell Chemical Biology. 26:1203-1213.e13
Summary The mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolic processes. Dysregulation of this kinase complex can result in a variety of human diseases. Rapamycin and its analogs target mTORC1 directly; however, chro
Autor:
Jason Shaoyun Xiang, Jianyao Wang, Seung Hahm, Louis Leung, Nicole Houvig, Mengmeng Wang, Eddine Saiah, Xin Xu, Vipin Suri, Xianbin Tian
Publikováno v:
Drug Metabolism Letters. 5:55-63
Diet-induced obese (DIO) mice have been commonly used as an animal model in the efficacy assessment for new drug candidates. Although high-fat feeding has been reported to cause profound physiological changes, including the expression of drug-metabol
Publikováno v:
Acta Pathologica Microbiologica Scandinavica. 69:431-436
Autor:
Darrell Panza, Kristine Svenson, Jason Shaoyun Xiang, Xianbin Tian, Christian E. Johnson, Xin Xu, James Tobin, Xiangping Li, Huan-Qiu Li, Mylene Perreault, Joel Bard, Tarek S. Mansour, Seung Hahm, Eddine Saiah, Ariful Qadri, Vipin Suri, Eva Chenail, Zhao-Kui Wan, Manus Ipek, Yuzhe Xing
Publikováno v:
Journal of Medicinal Chemistry. 52:5449-5461
Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11beta-hydroxysteroid dehydrogenase type I (11beta-HSD1). 2,4-Disubsitu
Autor:
Manus Ipek, Zhao-Kui Wan, Eva Binnun, Tarek S. Mansour, Jason Shaoyun Xiang, Seung Hahm, Xiangping Li, Huan-Qiu Li, James Tobin, Eddine Saiah, Vipin Suri, Yuzhe Xing, May Tam, Lihren Chen, John C. McKew, Jill Nunez, Xin Xu
Publikováno v:
Journal of Medicinal Chemistry. 51:4068-4071
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol. Evidence suggests that selective inhibition of 11beta-HSD1 could treat diabetes and metabolic syndrome. Presented herein are the synthesis, st
Autor:
Stephen R.J. Salton, Gian-Luca Ferri, Susan E. Snyder, Andrea Levi, Seung Hahm, Anna J. Wilson, Roberta Possenti
Publikováno v:
Frontiers in neuroendocrinology
21 (2000): 199–219.
info:cnr-pdr/source/autori:Salton S.RJ., Ferri. G.L., Hahm S., Snyder S.E., Wilson A.J., Possenti R., Levi A./titolo:VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance./doi:/rivista:Frontiers in neuroendocrinology (Print)/anno:2000/pagina_da:199/pagina_a:219/intervallo_pagine:199–219/volume:21
21 (2000): 199–219.
info:cnr-pdr/source/autori:Salton S.RJ., Ferri. G.L., Hahm S., Snyder S.E., Wilson A.J., Possenti R., Levi A./titolo:VGF: a novel role for this neuronal and neuroendocrine polypeptide in the regulation of energy balance./doi:/rivista:Frontiers in neuroendocrinology (Print)/anno:2000/pagina_da:199/pagina_a:219/intervallo_pagine:199–219/volume:21
Insight into the mechanisms of action of neurotrophic growth factors has been obtained through the identification and characterization of gene products that are regulated or modified at the transcriptional, translational, and/or posttranslational lev