Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Seung‐Wook Chung"'
Autor:
Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M. Souza, Daniela Rodrigues, Danyel G. J. Jennen, Theo M. deKok, Luke Coyle, Seung‐Wook Chung, Sofia Ferreira, Heeseung Jo, Kylie A. Beattie, Colette Kelly, Carrie A. Duckworth, D. Mark Pritchard, Carmen Pin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1511-1528 (2023)
Abstract We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestina
Externí odkaz:
https://doaj.org/article/ad07b2f07f9e481a9365795b33099f08
Autor:
Daniela Rodrigues, Bram Herpers, Sofia Ferreira, Heeseung Jo, Ciarán Fisher, Luke Coyle, Seung-Wook Chung, Jos C. S. Kleinjans, Danyel G. J. Jennen, Theo M. de Kok
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2213 (2022)
Gefitinib is a tyrosine kinase inhibitor (TKI) that selectively inhibits the epidermal growth factor receptor (EGFR), hampering cell growth and proliferation. Due to its action, gefitinib has been used in the treatment of cancers that present abnorma
Externí odkaz:
https://doaj.org/article/4de562a193ea486692617bf5fe96ab6b
Autor:
Daniela Rodrigues, Luke Coyle, Barbara Füzi, Sofia Ferreira, Heeseung Jo, Bram Herpers, Seung-Wook Chung, Ciarán Fisher, Jos C. S. Kleinjans, Danyel Jennen, Theo M. de Kok
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1286 (2022)
Doxorubicin is widely used in the treatment of different cancers, and its side effects can be severe in many tissues, including the intestines. Symptoms such as diarrhoea and abdominal pain caused by intestinal inflammation lead to the interruption o
Externí odkaz:
https://doaj.org/article/5d43ebfeb87440848856842729d962b5
Autor:
Johanna Vappiani, Terezinha de Souza, Theo M. de Kok, Luke Coyle, Julio Saez-Rodriguez, Danyel Jennen, Daniel C. Sévin, D. F. Rodrigues, Seung-Wook Chung, Matteo Di Piazza, Bram Herpers, Attila Gábor, Mian Zhang, Anthony M. Lynch, Jos C. S. Kleinjans, Sofia Ferreira
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 95(8), 2691-2718. Springer
Archives of Toxicology, 95(8), 2691-2718. Springer
5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. However, there is limited understanding of t
Autor:
Hansol Kim, Jungbae Kim, Ho Nam Chang, Seong H. Kim, Byung-Gee Kim, Hyon Bin Na, Jay W. Grate, Byoung Chan Kim, Erik Hsiao, Seung wook Chung, Byoungsoo Lee, Jongkyu Youn, Jinwoo Lee, Taeghwan Hyeon, Sung Gil Hong, Changwon Lee, Jonathan S. Dordick, Hyun Gyu Park
Publikováno v:
Chemical Engineering Journal. 322:510-515
For the encapsulation of biomolecules in inorganic materials, we have developed a unique enzyme-silicate conjugate material that consists of a self-assembled molecularly thin silicate layer on the surface of each individual enzyme molecule. The enzym
Publikováno v:
Bioprocess and Biosystems Engineering. 33:71-78
Five recombinant Escherichia coli extracts harboring overexpressed galactokinase, galactose-1-phosphate uridyltransferase, UDP-glucose pyrophophorylase, UMP kinase, and acetate kinase (AK) were utilized for the production of UDP-galactose (UDP-Gal).
Autor:
Jungbae Kim, Jay W. Grate, Ping Wang, Byung-Gee Kim, Alice Dohnalkova, Ja Hun Kwak, Seung wook Chung, Hongfei Jia, Changwon Lee, Yongsoon Shin
Publikováno v:
Enzyme and Microbial Technology. 39:474-480
Single enzyme nanoparticles of α-chymotrypsin (SEN-CT), in which each CT molecule is surrounded by a thin polymeric organic/inorganic network, stabilized the CT activity in a shaking condition as well as in a non-shaking condition. Since SEN-CT is s
Publikováno v:
Enzyme and Microbial Technology. 39:60-66
The N-glycans in human immunoglobulin G were engineered through the bacterial glycosyltransferase-catalyzed galactosylation and sialylation with in situ regeneration of sugar-nucleotides. For the galactosylation and sialylation, β1,4-galactosyltrans
Publikováno v:
Science translational medicine. 4(126)
The emerging discipline of systems pharmacology aims to combine analysis and computational modeling of cellular regulatory networks with quantitative pharmacology approaches to drive the drug discovery processes, predict rare adverse events, and cata
Publikováno v:
Journal of the Royal Society, Interface. 9(71)
TGF-β, a key cytokine that regulates diverse cellular processes, including proliferation and apoptosis, appears to function paradoxically as a tumour suppressor in normal cells, and as a tumour promoter in cancer cells, but the mechanisms underlying