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Akademický článek

Differences in impact on disease or lung injury depending on the physicochemical characteristics of harmful chemicals in the PAH model

Autor: Chul-Min Park, Seulgi Jeon, Mi-Jin Yang, Min-Seok Kim

Publikováno v: Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116838- (2024)

The number of individuals with underlying medical conditions has been increasing steadily. These individuals are relatively vulnerable to harmful external factors. But it has not been proven that the effects of hazardous chemicals may differ dependin

Externí odkaz: https://doaj.org/article/ae40da72100d40e48348e460db1bb057

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Akademický článek

Nicotinamide adenine dinucleotide phosphate oxidase 2 deletion attenuates polyhexamethylene guanidine-induced lung injury in mice

Autor: Yoon Cho, Seulgi Jeon, Sung-Hwan Kim, Hyeon-Young Kim, Bumseok Kim, Mi-Jin Yang, Jinhyung Rho, Moo-Yeol Lee, Kyuhong Lee, Min-Seok Kim

Publikováno v: Heliyon, Vol 10, Iss 3, Pp e25045- (2024)

Inhalation of polyhexamethylene guanidine phosphate (PHMG) can cause pulmonary fibrosis. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are enzymes that produce reactive oxygen species, which may be involved in tissue damage in va

Externí odkaz: https://doaj.org/article/0c7c599781fd4d2b99bf38c88f3e096b

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Akademický článek

The miR-15b-Smurf2-HSP27 axis promotes pulmonary fibrosis

Autor: Seulgi Jeon, Hee Jin, Jin-Mo Kim, Youmin Hur, Eun Joo Song, Yoon-Jin Lee, Younghwa Na, Jaeho Cho, Yun-Sil Lee

Publikováno v: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-15 (2023)

Abstract Background Heat shock protein 27 (HSP27) is overexpressed during pulmonary fibrosis (PF) and exacerbates PF; however, the upregulation of HSP27 during PF and the therapeutic strategy of HSP27 inhibition is not well elucidated. Methods We hav

Externí odkaz: https://doaj.org/article/d0a375e845924f3cbfe10b963f6260a5

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Akademický článek

Drug like HSP27 cross linkers with chromenone structure ameliorates pulmonary fibrosis

Autor: Young Jo Yoo, Seulgi Jeon, Hee Jin, Hee Yeon Won, Mi Gyeong Jeong, Yeseul Cho, Eun Sook Hwang, Younghwa Na, Jaeho Cho, Yun-Sil Lee

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Background: Pulmonary fibrosis (PF) is a progressive lung disease characterized by fibroblast accumulation and collagen deposition, resulting in lung scarring and impaired gas exchange. Current treatments for idiopathic pulmonary fibrosis (IPF) have

Externí odkaz: https://doaj.org/article/d204f7a99021418ca804732268592569

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Akademický článek

HSPB1 inhibitor J2 attenuates lung inflammation through direct modulation of Ym1 production and paracrine signaling

Autor: Areum Oh, Seulgi Jeon, Mi Gyeong Jeong, Hyo Kyeong Kim, Jio Kang, Yun-Sil Lee, Eun Sook Hwang

Publikováno v: Biomedicine & Pharmacotherapy, Vol 143, Iss , Pp 112225- (2021)

Heat shock protein beta-1 (HSPB1) is a multifaceted protein that controls cellular stress, modulates cell differentiation and development, and inhibits apoptosis of cancer cells. Increased HSPB1 expression is highly associated with poor outcomes in l

Externí odkaz: https://doaj.org/article/5fc23238ee6641589cafb81ad11214d2

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