Zobrazeno 1 - 10
of 837
pro vyhledávání: '"Settore CHIM/08 - CHIMICA FARMACEUTICA"'
Autor:
de Carvalho Bertozo L., Tutone M., Pastrello B., da Silva-Filho L. C., Culletta G., Almerico A. M., Farias Ximenes V.
An aminoquinoline (AQ4) was developed and proven to be a new and efficient DNA minor groove fluorescent probe. The specificity for DNA minor groove was attested by comparing it with well-established DNA probes such as Hoechst stain, acridine orange,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3658::a1535c436cd3445cffc1f4e7cce7bf7c
https://hdl.handle.net/10447/597973
https://hdl.handle.net/10447/597973
Autor:
Longbin Liu, Peter D. Johnson, Michael E. Prime, Vinod Khetarpal, Christopher J. Brown, Luca Anzillotti, Daniele Bertoglio, Xuemei Chen, Samuel Coe, Randall Davis, Anthony P. Dickie, Simone Esposito, Elise Gadouleau, Paul R. Giles, Catherine Greenaway, James Haber, Christer Halldin, Scott Haller, Sarah Hayes, Todd Herbst, Frank Herrmann, Manuela Heßmann, Ming Min Hsai, Yaser Khani, Adrian Kotey, Angelo Lembo, John E. Mangette, Gwendolyn A. Marriner, Richard W. Marston, Matthew R. Mills, Edith Monteagudo, Anton Forsberg-Morén, Sangram Nag, Laura Orsatti, Christine Sandiego, Sabine Schaertl, Joanne Sproston, Steven Staelens, Jack Tookey, Penelope A. Turner, Andrea Vecchi, Maria Veneziano, Ignacio Muñoz-Sanjuan, Jonathan Bard, Celia Dominguez
Publikováno v:
Journal of Medicinal Chemistry. 66:641-656
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
The interest in the photochromism and functional applications of donor-acceptor Stenhouse adducts (DASAs) soared in recent years owing to their outstanding advantages and flexible design. However, their low solubility and irreversible conversion in a
Autor:
Pietro Salvatore Carollo, Marco Tutone, Giulia Culletta, Ignazio Fiduccia, Federica Corrao, Ivana Pibiri, Maria Grazia Zizzo, Raffaella Melfi, Andrea Pace, Anna Maria Almerico, Laura Lentini
Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are "stop" mutations, which generate a Premature Termination Codon (PTC),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3658::eb735107b3e0709e99f592758810dbef
https://hdl.handle.net/10447/592653
https://hdl.handle.net/10447/592653
Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel
Autor:
Renda M., Barreca M., Borrelli A., Spano' V., Montalbano A., Raimondi M. V., Bivacqua R., Musante I., Scudieri P., Guidone D., Buccirossi M., Genovese M., Venturini A., Bandiera T., Barraja P., Galietta L. J. V.
Publikováno v:
Scientific Reports. 13
F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular retention and CFTR degradation. The F508del defect can be targeted with pharmacological corre
Autor:
Li Petri, Giovanna, Holl, Ralph, Spano', Virginia, Barreca, Marilia, Sardo, Ignazio, Raimondi, Maria Valeria
Publikováno v:
Frontiers in Chemistry. 11
Heterocycles represent a privileged scaffold due to their ability to interact with biological systems via heteroatoms. It is no coincidence that every year the Food and Drug Administration approves numerous new drugs that contain at least one heteroc
Autor:
Davide Capelli, Giulia Cazzaniga, Matteo Mori, Antonio Laghezza, Fulvio Loiodice, Martina Quaglia, Elisa Negro, Fiorella Meneghetti, Stefania Villa, Roberta Montanari
Publikováno v:
Biomolecules; Volume 13; Issue 4; Pages: 694
PPARγ represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARγ agonism profile of traditional antidiabetic drugs, a new opportunity is represented by the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9cf05753e61579b3215b667bae7403
https://hdl.handle.net/2434/966596
https://hdl.handle.net/2434/966596