Human TRMT2A methylates tRNA and contributes to translation fidelity

Autor: Witzenberger, M., Burczyk, S., Settele, D., Mayer, W., Welp, L., Heiss, M., Wagner, M., Monecke, T., Janowski, R., Carell, T., Urlaub, H., Hauck, S., Voigt, A., Niessing, D.

Publikováno v: Nucleic Acids Research

5-Methyluridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme for m5U formation at tRNA position 54. However, its RNA binding specificity an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1874::37eec37c21e807800f1f83e756730a30
https://hdl.handle.net/21.11116/0000-000D-70A7-821.11116/0000-000D-70A9-6

Human TRMT2A methylates tRNA and contributes to translation fidelity.

Autor: Witzenberger M; Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Burczyk S; Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany., Settele D; Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Mayer W; Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany., Welp LM; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Institute of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany., Heiss M; Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, München, Germany., Wagner M; Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, München, Germany., Monecke T; Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany., Janowski R; Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Carell T; Department of Chemistry and Biochemistry, Ludwig-Maximilians University Munich, München, Germany., Urlaub H; Bioanalytical Mass Spectrometry Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.; Institute of Clinical Chemistry, University Medical Center Göttingen, Göttingen, Germany., Hauck SM; Metabolomics and Proteomics Core, Research Unit Protein Science, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Voigt A; Department of Neurology, Faculty of Medicine, RWTH Aachen, Aachen, Germany., Niessing D; Institute of Structural Biology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Pharmaceutical Biotechnology, Ulm University, Ulm, Germany.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Sep 08; Vol. 51 (16), pp. 8691-8710.