Výsledky vyhledávání - "Setsuko Handa"

Akademický článek

Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis

Autor: Yoshitaka Kondo, Hirofumi Masutomi, Yoshihiro Noda, Yusuke Ozawa, Keita Takahashi, Setsuko Handa, Naoki Maruyama, Takahiko Shimizu, Akihito Ishigami

Publikováno v: FEBS Open Bio, Vol 4, Iss C, Pp 522-532 (2014)

Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen. The senescence marker protein-30 (SMP30) is a gluconolactonase that functions as an antioxidant protein in mam

Externí odkaz: https://doaj.org/article/36d5a56128a14523b606f1b45e9e3aea

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Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains

Autor: Akihito Ishigami, Megumi Nakamura, Yoshiaki Uchida, Shuuichi Nakaya, Byungki Jang, Hirofumi Masutomi, Yong-Chul Jeon, Tosifusa Toda, Setsuko Handa, Yasushi Kasahara, Shigeo Murayama, Eun-Kyoung Choi, Yuko Saito, Naoki Maruyama, Yong-Sun Kim

Publikováno v: Journal of Neuroscience Research. 93:1664-1674

Peptidylarginine deiminases (PADs) are posttranslational modification enzymes that convert protein arginine to citrulline residues in a calcium ion-dependent manner. Previously, we reported the abnormal accumulation of citrullinated proteins and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::175613ed45ea50b60d723180e6223a3a
https://doi.org/10.1002/jnr.23620

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Age-associated decrease of senescence marker protein-30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence

Autor: Hirofumi Masutomi, Setsuko Handa, Akihito Ishigami, Naoki Maruyama

Publikováno v: Geriatrics & Gerontology International. 15:804-810

Aim Senescence marker protein-30 (SMP30)/gluconolactonase (GNL) is an age-associated protein in that its presence decreases with aging. Here, we used immunohistochemical analysis to investigate the changes of SMP30/GNL in individual cells of the live

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dfc664ed35adebb713ff95718637bc1
https://doi.org/10.1111/ggi.12347

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Potato Chip Intake Increases Ascorbic Acid Levels and Decreases Reactive Oxygen Species in SMP30/GNL Knockout Mouse Tissues

Autor: Rui Sakuma, Hiroyuki Mugita, Misako Kubo, Katsuyuki Ishihara, Setsuko Handa, Megumi Ichisawa, Akihito Ishigami, Hidenori Koga, Naoki Maruyama, Yoshitaka Kondo

Publikováno v: Journal of Agricultural and Food Chemistry. 62:9286-9295

Potato chips (PC) contain abundant amounts of the free radical scavenger ascorbic acid (AA) due to the rapid dehydration of potato tubers (Solanum tuberosum) that occurs during frying. To evaluate the antioxidant activity of PC, this study examined r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc23f958a072a90b9edb57a27bc91ad
https://doi.org/10.1021/jf502587j

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Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice

Autor: Naoki Maruyama, Yasunori Sato, Yuki Kishimoto, Akihito Ishigami, Keita Takahashi, Akiko Amano, Setsuko Handa

Publikováno v: Geriatrics & Gerontology International. 14:989-995

Aim Senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice are incapable of synthesizing L-ascorbic acid (AA) in vivo. As AA is known to be a water-soluble anti-oxidant, we assessed protein oxidation levels in livers from SMP3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9dcb6f0938aa53ec06e5d72f036bf08
https://doi.org/10.1111/ggi.12162

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Two novel sandwich ELISAs identify PAD4 levels and PAD4 autoantibodies in patients with rheumatoid arthritis

Autor: Setsuko Handa, Yasushi Kasahara, Eun-Kyoung Choi, Yong-Sun Kim, Naoki Maruyama, Tsuyoshi Miyazaki, Akihito Ishigami, Yoshiaki Uchida

Publikováno v: Modern Rheumatology. 23:794-803

The peptidylarginine deiminase 4 (PAD4) gene and PAD4 autoantibodies have been associated with rheumatoid arthritis (RA) and its pathogenesis. Therefore, methods for accurately determining their levels in the peripheral blood of these patients would

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a1ccc125b3648fe4c125c2cf1c4542
https://doi.org/10.3109/s10165-012-0748-0

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Senescence marker protein 30 is up-regulated in kainate-induced hippocampal damage through ERK-mediated astrocytosis

Autor: Min-Sun Kim, Hae Young Chung, Jaewon Lee, Keunho Kim, Akihito Ishigami, Tae Gen Son, Naoki Maruyama, So Jung Kim, Setsuko Handa, Hee Ra Park

Publikováno v: Journal of Neuroscience Research. 87:2890-2897

Senescence maker protein 30 (SMP30) is decreased in an androgen-independent manner in kidney and liver with age. However, regulation of SMP30 expression in the brain has not been examined in aging and neurodegenerative diseases. To investigate SMP30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b7415054b610ea285c9d487bc9e7e6
https://doi.org/10.1002/jnr.22122

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Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

Autor: Hiroshi Obayashi, Akiko Amano, Toru Sasaki, Michiaki Fukui, Setsuko Handa, Goji Hasegawa, Toyotaka Mori, Yasunori Sato, Yoshitaka Kondo, Akihito Ishigami, Ryoya Takahashi, Mitsuhiro Ohta, Naoto Nakamura, Hikohito Fujinawa, Shizuo Kajiyama, Naoki Maruyama

Publikováno v: Biochemical and Biophysical Research Communications. 375:346-350

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72426b7530cdd53786be44acfc9a7a8
https://doi.org/10.1016/j.bbrc.2008.08.020

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Vitamin C Is Not Essential for Carnitine Biosynthesis in Vivo: Verification in Vitamin C-Depleted Senescence Marker Protein-30/Gluconolactonase Knockout Mice

Autor: Mizuki Iwama, Morimitsu Nishikimi, Ryoya Takahashi, Akiko Amano, Yoshitaka Kondo, Hajime Furusawa, Akira Murata, Akihito Ishigami, Yasukazu Tanaka, Yoko Inai, Sataro Goto, Yasunori Sato, Naoki Maruyama, Setsuko Handa

Publikováno v: Biological and Pharmaceutical Bulletin. 31:1673-1679

Carnitine is an essential cofactor in the transport of long-chain fatty acids into the mitochondrial matrix and plays an important role in energy production via beta-oxidation. Vitamin C (VC) has long been considered a requirement for the activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb41fba47913c590636f3af4a6032d6
https://doi.org/10.1248/bpb.31.1673

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Senescence marker protein 30 functions as gluconolactonase in l -ascorbic acid biosynthesis, and its knockout mice are prone to scurvy

Autor: Kentaro Shimokado, Morimitsu Nishikimi, Sataro Goto, Yasunori Sato, Akihito Ishigami, Yoko Inai, Yoshitaka Kondo, Sachiho Kubo, Naoki Maruyama, Setsuko Handa

Publikováno v: Proceedings of the National Academy of Sciences. 103:5723-5728

We originally identified senescence marker protein 30 (SMP30) as a distinctive protein whose expression decreases in an androgen-independent manner with aging. Here, we report its sequence homology found in two kinds of bacterial gluconolactonases (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd40ec2d759ac0f7f90bf91a475d108c
https://doi.org/10.1073/pnas.0511225103

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