Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Seth-Olov Thorberg"'
Autor:
Carin Wallsten, Ingalill Gagner Milchert, Göran Öjteg, Carina Stenfors, Eva Jerning, Nina Mohell, Svante B. Ross, Seth-Olov Thorberg
Publikováno v:
CNS Drug Reviews. 5:213-232
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469a8d2a0d58996ad212a29d6b07cdd9
https://doi.org/10.1111/j.1527-3458.1999.tb00101.x
https://doi.org/10.1111/j.1527-3458.1999.tb00101.x
Autor:
Seth-Olov Thorberg, Lars Farde, Christer Halldin, Yuan-Hwa Chou, Carl-Gunnar Swahn, Johan Sandell
Publikováno v:
Nuclear Medicine and Biology. 29:39-45
NAD-299 is a selective 5-HT 1A receptor antagonist that is currently developed as a putative antidepressant drug. [ 11 C]NAD-299 was examined in the cynomolgus monkey brain with positron emission tomography (PET). After radioligand injection high acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae14e5dece4ceed90a6ddc6059ad614f
https://doi.org/10.1016/s0969-8051(01)00272-4
https://doi.org/10.1016/s0969-8051(01)00272-4
Publikováno v:
Nuclear Medicine and Biology. 27:515-521
Positron-emission tomography (PET) provides potential in neuropsychiatric drug development by expanding knowledge of drug action in the living human brain and reducing time consumption and costs. The 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fcc70d579fd074a2f126b433d28cd8
https://doi.org/10.1016/s0969-8051(00)00121-9
https://doi.org/10.1016/s0969-8051(00)00121-9
Publikováno v:
Neuropsychopharmacology. 22:422-429
The serotonin 5-hydroxytryptamine-1A (5-HT(1A)) receptor subtype is of central interest in research, particularly in the area of pathophysiology and pharmacological treatment of psychiatric disorders. Robalzotan (generic name for NAD-299) is a new pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6def7691d1952142a20c1f67d90ad216
https://doi.org/10.1016/s0893-133x(99)00125-6
https://doi.org/10.1016/s0893-133x(99)00125-6
Autor:
Rolf Johansson, Lars Johansson, Ingeborg Csöregh, Martin Nylöf, Sverker Hanson, Nina Mohell, Eva Hammarberg, Bo-Ragnar Tolf, Charlotte Ahlgren, Anita Westlind-Danielsson, Gun Torell Svantesson, Robert Leideborg, Gunnar Nordvall, Eva Jerning, Seth-Olov Thorberg
Publikováno v:
Journal of medicinal chemistry. 43(15)
A series of new enantiomerically pure 3-amino-3,4-dihydro-2H-1-benzopyrans (3-aminochromans) has been synthesized from (R)- and (S)-5-methoxy-3-amino-3,4-dihydro-2H-1-benzopyran. The absolute configuration of the respective (R)- and (S)-enantiomers w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c14c99657cc620a84c524d93ec8c1e2
https://pubmed.ncbi.nlm.nih.gov/10956192
https://pubmed.ncbi.nlm.nih.gov/10956192
Publikováno v:
Psychopharmacology. 144(3)
The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9684c1a91b7d787065f4fe086a8332
https://pubmed.ncbi.nlm.nih.gov/10435400
https://pubmed.ncbi.nlm.nih.gov/10435400
Autor:
Johan Sandell, Christer Halldin, Seth-Olov Thorberg, Göran Sedvall, Lars Farde, Tom Werner, Daniel Sohn, Håkan Hall
Publikováno v:
Nuclear medicine and biology. 26(2)
The selective 5-HT 1A receptor antagonist NAD-299 ([ R ]-3- N , N -dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide) was labeled with the positron-emitting radionuclide carbon-11. The radioligand was synthesized from NAD-195 ([ R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e929e4e3c86aec6b8bbd4cbc866255e
https://pubmed.ncbi.nlm.nih.gov/10100214
https://pubmed.ncbi.nlm.nih.gov/10100214
Autor:
Seth-Olov Thorberg, U. Hacksell, J. L. G. Nilsson, Domingo Sanchez, Per Olov Lindberg, L.-E. Arvidsson, Johansson Am, Håkan Wikström, Stephan Hjorth, Kjell A. Svensson
Publikováno v:
Journal of Medicinal Chemistry. 27:1030-1036
Seven enantiomeric pairs of N-alkyl analogues of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP, 12) have been synthesized and evaluated pharmacologically (biochemistry and behavior) in order to examine their ability to interact with central dopamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f9f3b009c5e04ee3a4ee8ee3228803
https://doi.org/10.1021/jm00374a016
https://doi.org/10.1021/jm00374a016
Publikováno v:
Tetrahedron. 41:129-139
A large scale synthesis for (-)-3-PPP has been developed. The racemic methoxy compound 1 was prepared in a three step procedure in 63% yield. This was resolved as a diastereomeric salt by crystallization of the (-)-di-p-toluoyltartrate. Two crystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10bcb8016c50c02d4516719416321464
https://doi.org/10.1016/s0040-4020(01)83477-3
https://doi.org/10.1016/s0040-4020(01)83477-3
Autor:
J. L. G. Nilsson, Stephan Hjorth, Domingo Sanchez, David Clark, L.-E. Arvidsson, U. Hacksell, Seth-Olov Thorberg, Kjell A. Svensson, Per Lennart Lindberg, Arvid Carlsson, Anette M. Johansson, H. Wikstroem
Publikováno v:
Chemischer Informationsdienst. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1ccac494601e5df1a3bf192fa8321d
https://doi.org/10.1002/chin.198503222
https://doi.org/10.1002/chin.198503222