Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Seth Y, Ablordeppey"'
Autor:
Gladys M. Asong, Felix Amissah, Chandrashekhar Voshavar, Augustine T. Nkembo, Elizabeth Ntantie, Nazarius S. Lamango, Seth Y. Ablordeppey
Publikováno v:
ACS Omega, Vol 5, Iss 51, Pp 32907-32918 (2020)
Externí odkaz:
https://doaj.org/article/6fbd15af11b54d00aa7bd6071482c507
Autor:
Chandrashekhar Voshavar, Seth Y. Ablordeppey, Nazarius S. Lamango, Augustine T. Nkembo, Gladys Asong, Elizabeth Ntantie, Felix Amissah
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 51, Pp 32907-32918 (2020)
ACS Omega, Vol 5, Iss 51, Pp 32907-32918 (2020)
Triple-negative breast cancer (TNBC) is one of the most malignant cancers associated with early metastasis, poor clinical prognosis, and high recurrence rate. TNBC is a distinct subtype of breast cancer that lacks estrogen receptor (ER), progesterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36985a19ef6f3dd934ddaedffdf77ac9
https://doi.org/10.1021/acsomega.0c03495
https://doi.org/10.1021/acsomega.0c03495
Autor:
Gladys M. Asong, Chandrashekhar Voshavar, Felix Amissah, Barbara Bricker, Nazarius S. Lamango, Seth Y. Ablordeppey
Publikováno v:
Cancers; Volume 14; Issue 24; Pages: 6047
Triple negative breast cancer (TNBC) is a type of breast cancer associated with early metastasis, poor prognosis, high relapse rates, and mortality. Previously, we demonstrated that SYA013, a selective σ2RL, could inhibit cell proliferation, suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0242e98cd8af897c3ebc7a18d51e9
https://doi.org/10.3390/cancers14246047
https://doi.org/10.3390/cancers14246047
Autor:
Chandrashekar Voshavar, Uma Maheshwar Gonela, Seth Y. Ablordeppey, Suresh Eyunni, Edward Ofori, Edem K. Onyameh, Hye Jin Kang, Barbara A. Bricker
Publikováno v:
Med Chem Res
Compound 1c, 2-(2-(3,4-Dihydroisoquinolin-2(1H)-yl)ethyl)-5-fluoro-2,3-dihydro-1H-inden-1-one was previously reported from our laboratory showing high affinity binding to the 5-HT7 receptor (Ki = 0.5 nM). However, compound 1c racemizes readily upon e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e95be8670ea45d3f6c43006bfc69f
https://europepmc.org/articles/PMC8942385/
https://europepmc.org/articles/PMC8942385/
Autor:
Gladys Asong, Terrick Andey, Felix Amissah, Barbara A. Bricker, Xue Y. Zhu, Seth Y. Ablordeppey, Nazarius S. Lamango
Publikováno v:
Bioorg Med Chem
Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one·2HCl (SYA013) 1 as a sigma ligand with moderate selectivity for the sigma-2 receptor. Given the overexpression of sigma receptors in solid tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92f52f1276b37ee25030be5ecfa32d8
https://doi.org/10.1016/j.bmc.2019.04.012
https://doi.org/10.1016/j.bmc.2019.04.012
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2421-2426
Several lines of evidence suggest that selective sigma-2 (σ2) ligands might be useful for the treatment of solid tumors. However, very few selective σ2 ligands have been identified. This study was aimed at identifying new selective σ2 receptor lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6d76dceb3000191698bf98c8db3262
https://doi.org/10.1016/j.bmc.2019.01.035
https://doi.org/10.1016/j.bmc.2019.01.035
Publikováno v:
New Journal of Chemistry. 43:2861-2864
Cu-Catalyzed, ligand and base free cross-coupling of aryl boronic acids with primary and secondary amines has been reported. This 'Chan-Evans-Lam' reaction has revealed that at room temperature, catalytic copper(II) acetate and ceric ammonium nitrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45d47b2becb0d37ec0efca02d7d168f
https://doi.org/10.1039/c8nj06145a
https://doi.org/10.1039/c8nj06145a
Publikováno v:
Biomedical Chromatography. 33
In previous structure-activity relationship studies to identify new and selective 5-HT7 receptor (5-HT7 R) ligands, we identified the chiral compound, 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f0af153539a7e5e8c3e10008fd805d
https://doi.org/10.1002/bmc.4565
https://doi.org/10.1002/bmc.4565
Publikováno v:
Biomed Chromatogr
In a previous structure activity relationship studies to identify new and selective 5-HT(7) receptor (5-HT(7)R) ligands, we have identified the chiral compound, 5-chloro-2-(2-(3,4-dihydroisoquinoline-2(1H)-yl)ethyl)-2-methyl-2,3-dihydro-1H-inden-1-on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dabb04a4097dd68768861eecaacadf69
https://pubmed.ncbi.nlm.nih.gov/31032988
https://pubmed.ncbi.nlm.nih.gov/31032988
SYA16263 exhibited moderate radioligand binding affinity at the D2 receptor and produced inhibition of apomorphine-induced climbing behavior in mice with an ED50 value of 3.88 mg/kg IP, predicting potential antipsychotic effects in humans. Analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb923ade78ff63718ce24bb37965361
https://europepmc.org/articles/PMC6581196/
https://europepmc.org/articles/PMC6581196/