Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Seth Winfree"'
Autor:
Debora L. Gisch, Michelle Brennan, Blue B. Lake, Jeannine Basta, Mark S. Keller, Ricardo Melo Ferreira, Shreeram Akilesh, Reetika Ghag, Charles Lu, Ying-Hua Cheng, Kimberly S. Collins, Samir V. Parikh, Brad H. Rovin, Lynn Robbins, Lisa Stout, Kimberly Y. Conklin, Dinh Diep, Bo Zhang, Amanda Knoten, Daria Barwinska, Mahla Asghari, Angela R. Sabo, Michael J. Ferkowicz, Timothy A. Sutton, Katherine J. Kelly, Ian H. De Boer, Sylvia E. Rosas, Krzysztof Kiryluk, Jeffrey B. Hodgin, Fadhl Alakwaa, Seth Winfree, Nichole Jefferson, Aydın Türkmen, Joseph P. Gaut, Nils Gehlenborg, Carrie L. Phillips, Tarek M. El-Achkar, Pierre C. Dagher, Takashi Hato, Kun Zhang, Jonathan Himmelfarb, Matthias Kretzler, Shamim Mollah, the Kidney Precision Medicine Project (KPMP), Sanjay Jain, Michael Rauchman, Michael T. Eadon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract There is a need to define regions of gene activation or repression that control human kidney cells in states of health, injury, and repair to understand the molecular pathogenesis of kidney disease and design therapeutic strategies. Comprehe
Externí odkaz:
https://doaj.org/article/8d81e0f3c4d54dd6b9a6681fc0df894c
Autor:
Victor Hugo Canela, William S. Bowen, Ricardo Melo Ferreira, Farooq Syed, James E. Lingeman, Angela R. Sabo, Daria Barwinska, Seth Winfree, Blue B. Lake, Ying-Hua Cheng, Joseph P. Gaut, Michael Ferkowicz, Kaice A. LaFavers, Kun Zhang, Fredric L. Coe, Elaine Worcester, the Kidney Precision Medicine Project, Sanjay Jain, Michael T. Eadon, James C. Williams, Tarek M. El-Achkar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Kidney stone disease causes significant morbidity and increases health care utilization. In this work, we decipher the cellular and molecular niche of the human renal papilla in patients with calcium oxalate (CaOx) stone disease and healthy
Externí odkaz:
https://doaj.org/article/9079daace87a49889ca16163b6717e46
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023)
Abstract The primary step in tissue cytometry is the automated distinction of individual cells (segmentation). Since cell borders are seldom labeled, cells are generally segmented by their nuclei. While tools have been developed for segmenting nuclei
Externí odkaz:
https://doaj.org/article/7d4ab3f8a0fe4d1ba0e9a37a5cd79844
Autor:
Kaitlin M Dailey, James M Small, Jessica E Pullan, Seth Winfree, Krysten E Vance, Megan Orr, Sanku Mallik, Kenneth W Bayles, Michael A Hollingsworth, Amanda E Brooks
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0289183 (2023)
Clostridium novyi has demonstrated selective efficacy against solid tumors largely due to the microenvironment contained within dense tumor cores. The core of a solid tumor is typically hypoxic, acidic, and necrotic-impeding the penetration of curren
Externí odkaz:
https://doaj.org/article/b537482f21ef4474b5d908f2d67ccbb3
Autor:
Tarek M. El-Achkar, Seth Winfree, Niloy Talukder, Daria Barwinska, Michael J. Ferkowicz, Mohammad Al Hasan
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Advances in cellular and molecular interrogation of kidney tissue have ushered a new era of understanding the pathogenesis of kidney disease and potentially identifying molecular targets for therapeutic intervention. Classifying cells in situ and ide
Externí odkaz:
https://doaj.org/article/b7f3a5b8d9c040928bd6b1ba40b71a3f
Autor:
Seth Winfree
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Advanced image analysis with machine and deep learning has improved cell segmentation and classification for novel insights into biological mechanisms. These approaches have been used for the analysis of cells in situ, within tissue, and confirmed ex
Externí odkaz:
https://doaj.org/article/d28366c3104e4fa3b7f4b26ae43668d6
Autor:
Angela R. Sabo, Seth Winfree, Sharon B. Bledsoe, Carrie L. Phillips, James E. Lingeman, Michael T. Eadon, James C. Williams Jr., Tarek M. El‐Achkar
Publikováno v:
Physiological Reports, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Label‐free fluorescence imaging of kidney sections can provide important morphological information, but its utility has not been tested in a histology processing workflow. We tested the feasibility of label‐free imaging of paraffin‐emb
Externí odkaz:
https://doaj.org/article/3c15538016cb48ddb698fcb19dbe9e10
Autor:
Mohammad Shahidul Makki, Seth Winfree, James E. Lingeman, Frank A. Witzmann, Elaine M. Worcester, Amy E. Krambeck, Fredric L. Coe, Andrew P. Evan, Sharon Bledsoe, Kristin J. Bergsland, Suraj Khochare, Daria Barwinska, James C. Williams, Jr., Tarek M. El-Achkar
Publikováno v:
Kidney International Reports, Vol 5, Iss 5, Pp 663-677 (2020)
Introduction: We have previously found that papillary histopathology differs greatly between calcium oxalate and brushite stone formers (SF); the latter have much more papillary mineral deposition, tubular cell injury, and tissue fibrosis. Methods: I
Externí odkaz:
https://doaj.org/article/389a098a8d9b451c8f2331649ba7370a
Autor:
Ricardo Melo Ferreira, Angela R. Sabo, Seth Winfree, Kimberly S. Collins, Danielle Janosevic, Connor J. Gulbronson, Ying-Hua Cheng, Lauren Casbon, Daria Barwinska, Michael J. Ferkowicz, Xiaoling Xuei, Chi Zhang, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Takashi Hato, Pierre C. Dagher, Tarek M. El-Achkar, Michael T. Eadon
Publikováno v:
JCI Insight, Vol 6, Iss 12 (2021)
Single-cell sequencing studies have characterized the transcriptomic signature of cell types within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional and affects cells heterogeneously. We first optimized coordinat
Externí odkaz:
https://doaj.org/article/71daba4ad199461d95bffa086ab6c6bf
Autor:
Danielle Janosevic, Jered Myslinski, Thomas W McCarthy, Amy Zollman, Farooq Syed, Xiaoling Xuei, Hongyu Gao, Yun-Long Liu, Kimberly S Collins, Ying-Hua Cheng, Seth Winfree, Tarek M El-Achkar, Bernhard Maier, Ricardo Melo Ferreira, Michael T Eadon, Takashi Hato, Pierre C Dagher
Publikováno v:
eLife, Vol 10 (2021)
Sepsis is a dynamic state that progresses at variable rates and has life-threatening consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the evolution of cellular and molecular events at the tissue level. Here, w
Externí odkaz:
https://doaj.org/article/95a72248ab2e4edb9c901a6ce089d3b0