Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Seth W. Dickey"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Staphylococcus aureus secretes phenol-soluble modulins (PSMs), a family of small, amphipathic, secreted peptides with multiple biologic activities. Community-acquired S. aureus strains produce high levels of PSMs in planktonic cultures, and
Externí odkaz:
https://doaj.org/article/160443d1516d43dda288430a463693e7
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/56862ed87b994500b317888779767bf6
Autor:
Yao Liu, Qian Liu, Lu Zhao, Seth W. Dickey, Hua Wang, Rui Xu, Tianchi Chen, Ying Jian, Xi Wang, Huiying Lv, Michael Otto, Min Li
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 4, Pp n/a-n/a (2022)
Abstract Bacterial membrane vesicles (MVs) have recently gained much attention and have been shown to carry a wide diversity of secreted bacterial components. However, it is poorly understood whether MV carriage is an indispensable requirement for a
Externí odkaz:
https://doaj.org/article/3c393610657a4d30852177c2c37f9a59
Autor:
Lei He, Feiyang Zhang, Ying Jian, Huiying Lv, Musha Hamushan, Junlan Liu, Yao Liu, Hua Wang, Jin Tang, Pei Han, Dylan J. Burgin, Seth W. Dickey, Hao Shen, Min Li, Michael Otto
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/c8f5c4ea4cb7460abaf7032ab542153e
Autor:
Britney L. Hardy, Seth W. Dickey, Roger D. Plaut, Daniel P. Riggins, Scott Stibitz, Michael Otto, D. Scott Merrell
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Commensal bacteria in the human nasal cavity are known to suppress opportunistic pathogen colonization by competing for limited space and nutrients. It has become increasingly apparent that some commensal bacteria also produce toxic compound
Externí odkaz:
https://doaj.org/article/968300a93e7a46579ddf54584e4a47fb
Autor:
Hwang-Soo Joo, Som S. Chatterjee, Amer E. Villaruz, Seth W. Dickey, Vee Y. Tan, Yan Chen, Daniel E. Sturdevant, Stacy M. Ricklefs, Michael Otto
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The virulence of many bacterial pathogens, including the important human pathogen Staphylococcus aureus, depends on the secretion of frequently large amounts of toxins. Toxin production involves the need for the bacteria to make physiologica
Externí odkaz:
https://doaj.org/article/61c33f922bf24eabbaba5dfb4d68f5fc
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Diverse organisms secrete amphipathic biomolecules for competitive gains. However, how cells cope with producing these membrane-permeabilizing molecules is unclear. We focused on the PSM family of secreted amphipathic peptides in the pathogen Staphyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e64da54999b16800552b0b353f7325e
https://doi.org/10.1073/pnas.2211689120
https://doi.org/10.1073/pnas.2211689120
Publikováno v:
Nature Reviews Drug Discovery. 16:457-471
Efforts to combat bacterial infections by targeting virulence factors are gaining traction, fuelled by the potential to circumvent the development of antibacterial resistance and recent landmark approvals of antivirulence drugs. Here, Otto and collea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec17ec9f1840b167633dbbd6c07eb9e9
https://doi.org/10.1038/nrd.2017.23
https://doi.org/10.1038/nrd.2017.23
Publikováno v:
Molecular Cell. 61(3):329-340
Intramembrane proteases signal by releasing proteins from the membrane, but despite their importance their enzymatic mechanisms remain obscure. We probed rhomboid proteases with reversible, mechanism-based inhibitors that allow precise kinetic analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a999b432efa806b0bd6eee996f225c0
Autor:
Michael Otto, Seth W. Dickey
Publikováno v:
Cell Host & Microbe. 22:581-583
Pyruvate dehydrogenase (PDH) plays a well-known metabolic role inside cells. In this issue of Cell Host & Microbe, Grayczyk et al. (2017) show that the bacterial pathogen Staphylococcus aureus unexpectedly secretes and repurposes the lipoylated E2 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7200830ab16e44cf93477e237a17d5b
https://doi.org/10.1016/j.chom.2017.10.018
https://doi.org/10.1016/j.chom.2017.10.018