Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Seth T. Scanlon"'
Autor:
Laurence S. C. Lok, Jennifer A. Walker, Helen E. Jolin, Seth T. Scanlon, Masaru Ishii, Padraic G. Fallon, Andrew N. J. McKenzie, Menna R. Clatworthy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Group 2 innate lymphoid cells (ILC2s) are early effectors of mucosal type 2 immunity, producing cytokines such as interleukin (IL)-13 to mediate responses to helminth infection and allergen-induced inflammation. ILC2s are also present in lymph nodes
Externí odkaz:
https://doaj.org/article/2c7b2790aff8439283a064b67e45a006
Autor:
Rebecca Mathew, Seth T. Scanlon, Kristin Hollister, Benjamin D. McDonald, Alexander L. Dent, Albert Bendelac, Aaron R. Dinner, Jeffrey J. Bunker, Michael G. Constantinides, Jeffrey D. Singer, Andrew H. Chiang, Ai-Ping Mao, Clara Bertozzi-Villa
Publikováno v:
The Journal of Experimental Medicine
Bcl6 and E3 ligase cullin 3 complexes mediate negative feedback regulation during thymocyte development and T cell activation to restrain exaggerated Tfh responses.
Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh)
Induction of Bcl6 (B cell lymphoma 6) is essential for T follicular helper (Tfh)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8748e13730cba52dfd3555836c4ddb8
https://doi.org/10.1084/jem.20132267
https://doi.org/10.1084/jem.20132267
Autor:
Andrew N. J. McKenzie, Luzheng Xue, Graham S. Ogg, Padraic G. Fallon, Li-Chieh Huang, Danuta Gutowska-Owsiak, Seth T. Scanlon, Maryam Salimi, Jillian L. Barlow, David Johnson, Sean P. Saunders, Xinwen Wang
Publikováno v:
The Journal of Experimental Medicine
Type 2 innate lymphoid cells promote skin inflammation in mice and men, in part by producing IL-5 and IL-13 in response to IL-33
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b6022edcaa3627b8ff85fbb2fbd5e9
https://doi.org/10.1084/jem.20130351
https://doi.org/10.1084/jem.20130351
Autor:
Maryam Salimi, James M. Brewer, Emily Hams, See Heng Wong, Graham S. Ogg, Andrew N J McKenzie, Seth T. Scanlon, Jillian L. Barlow, Alexandros Englezakis, Christopher J. Oliphant, Jennifer A. Walker, Padraic G. Fallon, You Yi Hwang
Publikováno v:
Immunity
Summary Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6fc7ea4d364d5c0795cba7745d1f92
https://doi.org/10.1016/j.immuni.2014.06.016
https://doi.org/10.1016/j.immuni.2014.06.016
Autor:
Albert Bendelac, Thomas Krausz, Seth T. Scanlon, Paul B. Savage, Li Bai, Caroline M. Ferreira, Seddon Y. Thomas
Publikováno v:
The Journal of Experimental Medicine
Resident intravascular NKT cells exacerbate airway hyperreactivity in mice dependent on dendritic cell co-presentation of glycolipid and peptide antigens.
Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate
Airborne exposure to microbial cell wall lipids such as lipopolysaccharide triggers innate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194d52571c4e90760fde727c16c0b9b9
https://doi.org/10.1084/jem.20110522
https://doi.org/10.1084/jem.20110522
Autor:
Albert Bendelac, Andrew D. Luster, Klaus G. Griewank, Seth T. Scanlon, Kenneth Barr, Fanyong Meng, Adam K. Savage, Michael G. Constantinides, Seddon Y. Thomas
Publikováno v:
The Journal of Experimental Medicine
PLZF-expressing NKT cells establish residence at intravascular locations, failing to enter the circulation because of constitutive interactions with LFA-1 and ICAM-1.
Innate-like NKT cells conspicuously accumulate within the liver microvasculatu
Innate-like NKT cells conspicuously accumulate within the liver microvasculatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe25b943c7cc626a14ecf4cd3369379b
http://europepmc.org/articles/PMC3173247
http://europepmc.org/articles/PMC3173247
Autor:
Natalio Garbi, Padraic G. Fallon, Timotheus Y.F. Halim, Habib Zaghouani, Andrew N. J. McKenzie, Seth T. Scanlon, You Yi Hwang
Publikováno v:
Nature immunology
Rapid activation of memory CD4(+) T helper 2 (TH2) cells during allergic inflammation requires their recruitment into the affected tissue. Here we demonstrate that group 2 innate lymphoid (ILC2) cells have a crucial role in memory TH2 cell responses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ff1ab2ccbd40b0f81f06997e2bf18e
https://pubmed.ncbi.nlm.nih.gov/26806480
https://pubmed.ncbi.nlm.nih.gov/26806480
Autor:
Trevor Fusaro, Andrew J. Gow, Seth T. Scanlon, Elena N. Atochina, James M. Beck, Michael F. Beers, John Casey, Yaniv Tomer, Angela M. Preston, Angela Franciska Haczku, Samuel Hawgood
Publikováno v:
Infection and Immunity. 72:6002-6011
Surfactant protein A (SP-A), a member of the collectin family, selectively binds toPneumocystis cariniiand mediates interactions between pathogen and host alveolar macrophages in vitro. To test the hypothesis that mice lacking SP-A have delayed clear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0880ad44c598c18f7ff511dd49189c7
https://doi.org/10.1128/iai.72.10.6002-6011.2004
https://doi.org/10.1128/iai.72.10.6002-6011.2004
Autor:
Seth T. Scanlon, A. N. J. McKenzie
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 45(1)
Summary Although type-2 immune responses evolved primarily to defend against extracellular helminths, in part through the co-opting of tissue repair and remodeling mechanisms, they are often inappropriately directed towards relatively innocuous aller
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98801869b9cbe56111cd7635009d7ed
https://pubmed.ncbi.nlm.nih.gov/25423949
https://pubmed.ncbi.nlm.nih.gov/25423949
Publikováno v:
Europe PubMed Central
Studies of Pneumocystis carinii pneumonia (PCP) suggest an important role for the surfactant system in the pathogenesis of the hypoxemic respiratory insufficiency associated with this infection. We hypothesized that PCP induces selective alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddcfc6ce0aff288feda6e015a322ffb
https://doi.org/10.1152/ajplung.2000.278.3.l599
https://doi.org/10.1152/ajplung.2000.278.3.l599