Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Seth T. Eisenman"'
Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis
Autor:
Madhusudan Grover, Simon J. Gibbons, Asha A. Nair, Cheryl E. Bernard, Adeel S. Zubair, Seth T. Eisenman, Laura A. Wilson, Laura Miriel, Pankaj J. Pasricha, Henry P. Parkman, Irene Sarosiek, Richard W. McCallum, Kenneth L. Koch, Thomas L. Abell, William J. Snape, Braden Kuo, Robert J. Shulman, Travis J. McKenzie, Todd A. Kellogg, Michael L. Kendrick, James Tonascia, Frank A. Hamilton, Gianrico Farrugia, the NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background Cellular changes described in human gastroparesis have revealed a role for immune dysregulation, however, a mechanistic understanding of human gastroparesis and the signaling pathways involved are still unclear. Methods Diabetic g
Externí odkaz:
https://doaj.org/article/20e8bd3f92e147689f45774f66978f5d
Autor:
Gianluca Cipriani, Simon J. Gibbons, Pieter-Jan Verhulst, Kyoung Moo Choi, Seth T. Eisenman, Stephanie S. Hein, Tamas Ordog, David R. Linden, Joseph H. Szurszewski, Gianrico Farrugia
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 1, Pp 40-47 (2016)
Background & Aims: Diabetic gastroparesis is associated with changes in interstitial cells of Cajal (ICC), neurons, and smooth muscle cells in both animal models and humans. Macrophages appear to be critical to the development of cellular damage that
Externí odkaz:
https://doaj.org/article/2bf9579190304b57859cf3583e6b5d0e
Autor:
Seth T. Eisenman, Peter R. Strege, Heather L. Holmes, Simon J. Gibbons, Cheryl E. Bernard, Amelia Mazzone, Maria Gabriela Colmenares Aguilar, Gianrico Farrugia, Michael F. Romero
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 320:G93-G107
In this study, we show that the electrogenic Na+/HCO3− cotransporter, NBCe1/Slc4a4, is expressed in subtypes of interstitial cells of Cajal (ICCs) responsible for electrical slow wave generation throughout the mouse gastrointestinal tract and is ab
Autor:
Martin E. Fernandez-Zapico, Peter R. Strege, Mauro D'Amato, Tenghao Zheng, Seth T. Eisenman, Simon J. Gibbons, Tamas Ordog, Amelia Mazzone, Gianrico Farrugia
Publikováno v:
The FASEB Journal. 33:6632-6642
The Ca2+-activated Cl- channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human ANO1 promoter contains binding sites for the g
Autor:
Lei Sha, Liwen Zhang, Wenchang Zhao, Maria Gabriela Colmenares Aguilar, David R. Linden, Simon J. Gibbons, Gianrico Farrugia, Michael F. Romero, Leonid G. Ermilov, Seth T. Eisenman
Publikováno v:
Neurogastroenterology & Motility. 33
Background Normal gastrointestinal motility depends on electrical slow-wave activity generated by interstitial cells of Cajal (ICC) in the tunica muscularis of the gastrointestinal tract. A requirement for HCO3 - in extracellular solutions used to re
Autor:
Wenchang, Zhao, Liwen, Zhang, Leonid G, Ermilov, Maria Gabriela, Colmenares Aguilar, David R, Linden, Seth T, Eisenman, Michael F, Romero, Gianrico, Farrugia, Lei, Sha, Simon J, Gibbons
Publikováno v:
Neurogastroenterol Motil
BACKGROUND: Normal gastrointestinal motility depends on electrical slow wave activity generated by interstitial cells of Cajal (ICC) in the tunica muscularis of the gastrointestinal tract. A requirement for HCO(3)(−) in extracellular solutions used
Autor:
Maria-Gabriela, Colmenares Aguilar, Amelia, Mazzone, Seth T, Eisenman, Peter R, Strege, Cheryl E, Bernard, Heather L, Holmes, Michael F, Romero, Gianrico, Farrugia, Simon J, Gibbons
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Interstitial cells of Cajal (ICCs) generate electrical slow waves, which are required for normal gastrointestinal motility. The mechanisms for generation of normal pacemaking are not fully understood. Normal gastrointestinal contractility(−) and el
Autor:
Peng Du, Chike Cao, Sabine Klein, Uhtaek Oh, Seth T. Eisenman, Gianrico Farrugia, Dieter Saur, Simon J. Gibbons, Tamas Ordog, John Malysz, Siva Arumugam Saravanaperumal
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 312:G228-G245
Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit+ electrical pacemakers that express the Ano1/TMEM16A Ca2+-activated Cl– channel, whose functions in the gastrointestinal tract remain incompletely understood. In t
Autor:
Gianrico Farrugia, Peter R. Strege, Amelia Mazzone, Gary E. Shull, Maria Gabriela Colmenares Aguilar, Simon J. Gibbons, Lei Sha, Wenchang Zhao, Seth T. Eisenman, Michael F. Romero
Publikováno v:
The FASEB Journal. 33
Autor:
Amelia, Mazzone, Simon J, Gibbons, Seth T, Eisenman, Peter R, Strege, Tenghao, Zheng, Mauro, D'Amato, Tamas, Ordog, Martin E, Fernandez-Zapico, Gianrico, Farrugia
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(5)
The Ca(2+)-activated Cl(−) channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human ANO1 promoter contains binding sites for