Výsledky vyhledávání - "Seth R Goldman"

Akademický článek

Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription

Autor: Umut Berkay Altıntaş, Ji-Heui Seo, Claudia Giambartolomei, Dogancan Ozturan, Brad J. Fortunato, Geoffrey M. Nelson, Seth R. Goldman, Karen Adelman, Faraz Hach, Matthew L. Freedman, Nathan A. Lack

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Androgen receptor (AR)-mediated transcription plays a critical role in development and prostate cancer growth. AR drives gene expression by binding to thousands of cis-regulatory elements (CRE) that loop to hundreds of target promoters. With

Externí odkaz: https://doaj.org/article/93ab95dbf1754e2ab49cc69bd6f1d784

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Akademický článek

The primary σ factor in Escherichia coli can access the transcription elongation complex from solution in vivo

Autor: Seth R Goldman, Nikhil U Nair, Christopher D Wells, Bryce E Nickels, Ann Hochschild

Publikováno v: eLife, Vol 4 (2015)

The σ subunit of bacterial RNA polymerase (RNAP) confers on the enzyme the ability to initiate promoter-specific transcription. Although σ factors are generally classified as initiation factors, σ can also remain associated with, and modulate the

Externí odkaz: https://doaj.org/article/75907457ebf64653997ad69ea9b4076f

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Akademický článek

A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5' RNA-seq.

Autor: Sergey Y Druzhinin, Ngat T Tran, Kyle S Skalenko, Seth R Goldman, Jared G Knoblauch, Simon L Dove, Bryce E Nickels

Publikováno v: PLoS Genetics, Vol 11, Iss 7, p e1005348 (2015)

Transcription initiation that involves the use of a 2- to ~4-nt oligoribonucleotide primer, "primer-dependent initiation," (PDI) has been shown to be widely prevalent at promoters of genes expressed during the stationary phase of growth in Escherichi

Externí odkaz: https://doaj.org/article/8ef4feb387c242d18ee98d486b20c72e

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A ubiquitous disordered protein interaction module orchestrates transcription elongation

Autor: Eric A. Smith, Zeger Debyser, Vaclav Veverka, Marcela Mádlíková, Milan Fábry, M. Horejsi, Seth R. Goldman, Vanda Lux, Monika Nedomova, H. Courtney Hodges, Pavel Srb, Jan De Rijck, Karen Adelman, Jonas Demeulemeester, Rozálie Hexnerová, Katerina Cermakova

Publikováno v: Science

Organized by unstructured motifs The high degree of conservation in protein sequences thought to be unstructured has hinted that these regions may have important biological functions. Although unstructured regions are widely viewed to be crucial for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c568e193dc8dcfef56eca62617fab1ae
https://europepmc.org/articles/PMC8943916/

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Negative elongation factor regulates muscle progenitor expansion for efficient myofiber repair and stem cell pool repopulation

Autor: Geoffrey M. Nelson, Daniel C.L. Robinson, Rémi Mounier, F. Jeffrey Dilworth, Michael A. Rudnicki, Seth R. Goldman, Zeinab Mokhtari, Karen Adelman, Bénédicte Chazaud, Marjorie Brand, Kiran Nakka, Peter J. Park, Morten Ritso, Hina Bandukwala

Publikováno v: Dev Cell
Developmental Cell
Developmental Cell, 2021, 56 (7), pp.1014-1029.e7. ⟨10.1016/j.devcel.2021.02.025⟩
Developmental Cell, Elsevier, 2021, 56 (7), pp.1014-1029.e7. ⟨10.1016/j.devcel.2021.02.025⟩

International audience; Negative elongation factor (NELF) is a critical transcriptional regulator that stabilizes paused RNA polymerase to permit rapid gene expression changes in response to environmental cues. Although NELF is essential for embryoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8dfe276af71194e56a85ea7bc6513e
https://pubmed.ncbi.nlm.nih.gov/33735618

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Negative Elongation Factor (NELF) Regulates Muscle Progenitor Expansion for Efficient Myofiber Repair and Stem Cell Pool Repopulation

Autor: Morten Ritso, Karen Adelman, Remi Mournier, Geoffrey M. Nelson, Kiran Nakka, Peter J. Park, Seth R. Goldman, Jeffrey Dilworth, Marjorie Brand, Daniel C.L. Robinson, Zeinab Mokhtari, Bénédicte Chazaud

Publikováno v: SSRN Electronic Journal.

Negative Elongation Factor (NELF) is a critical transcriptional regulator that works through stabilizing paused RNA Polymerase to permit rapid gene expression changes in response to environmental cues. Whilst NELF is essential for embryonic developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a2bcca6da9c767bdd3cc2854f704579
https://doi.org/10.2139/ssrn.3596602

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Analysis of Bacterial Transcription by 'Massively Systematic Transcript End Readout,' MASTER

Autor: Bryce E. Nickels, Seth R. Goldman, Irina O. Vvedenskaya

A systems-level view of cellular gene expression requires understanding the mechanistic principles governing each step of transcription. In this chapter, we describe a massively multiplexed method for the analysis of the relationship between nucleic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc45d4076c66b9106d50863860e8075
https://doi.org/10.1016/bs.mie.2018.09.007

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Interactions between RNA polymerase and the 'core recognition element' counteract pausing

Autor: Bryce E. Nickels, Jeremy G. Bird, Jared Knoblauch, Irina O. Vvedenskaya, Richard H. Ebright, Seth R. Goldman, Yu Zhang, Hanif Vahedian-Movahed

Publikováno v: Science. 344:1285-1289

Pausing for control of gene expression Pausing during gene transcription can play a critical role in gene regulation. Vvedenskaya et al. mapped pause sites across the whole genome in actively growing Escherichia coli (see the Perspective by Roberts).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab9dd6422c665c1c3c661299806b0f2b
https://doi.org/10.1126/science.1253458

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Growth phase-dependent control of transcription start site selection and gene expression by nanoRNAs

Autor: Josh S. Sharp, Jonathan Livny, Simon L. Dove, Bryce E. Nickels, Seth R. Goldman, Pinal N. Kanabar, Irina O. Vvedenskaya

Publikováno v: Genes & Development. 26:1498-1507

Prokaryotic and eukaryotic RNA polymerases can use 2- to ∼4-nt RNAs, “nanoRNAs,” to prime transcription initiation in vitro. It has been proposed that nanoRNA-mediated priming of transcription can likewise occur under physiological conditions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cfe56cf6cd2eef7d6a9e013fa63321
https://doi.org/10.1101/gad.192732.112

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NanoRNAs Prime Transcription Initiation In Vivo

Autor: Jonathan Livny, Irina O. Vvedenskaya, Seth R. Goldman, Bryce E. Nickels, Simon L. Dove, Josh S. Sharp

Publikováno v: Molecular Cell. 42:817-825

It is often presumed that, in vivo, the initiation of RNA synthesis by DNA-dependent RNA polymerases occurs using NTPs alone. Here, using the model Gram-negative bacterium Pseudomonas aeruginosa, we demonstrate that depletion of the small-RNA-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f98df607656529e36979abb24dd93e6
https://doi.org/10.1016/j.molcel.2011.06.005

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