Neuroprotection and Stroke Rehabilitation: Modulation and Enhancement of Recovery

Autor: José Rafael Romero, Viken L. Babikian, Douglas I. Katz, Seth P. Finklestein

Publikováno v: Behavioural Neurology, Vol 17, Iss 1, Pp 17-24 (2006)

Recent advances in research are modifying our view of recovery after nervous system damage. New findings are changing previously held concepts and providing promising avenues for treatment of patients after stroke. This review discusses mechanisms of

Externí odkaz: https://doaj.org/article/7632e0e410594eb09fe88db4e4522b6d

Association of Modified Rankin Scale With Recovery Phenotypes in Patients With Upper Extremity Weakness After Stroke

Autor: Kimberly S. Erler, Rui Wu, Julie A. DiCarlo, Marina F. Petrilli, Perman Gochyyev, Leigh R. Hochberg, Steven A. Kautz, Lee H. Schwamm, Steven C. Cramer, Seth P. Finklestein, David J. Lin

Publikováno v: Neurology, vol 98, iss 18
Neurology

Background and ObjectivesPrecise measurement of outcomes is essential for stroke trials and clinical care. Prior research has highlighted conceptual differences between global outcome measures such as the modified Rankin Scale (mRS) and domain-specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bfa20a552cb874129cd14f27a9c630
https://escholarship.org/uc/item/2v37z35q

Use of Anisotropy, 3D Segmented Atlas, and Computational Analysis to Identify Gray Matter Subcortical Lesions Common to Concussive Injury from Different Sites on the Cortex.

Autor: Praveen Kulkarni, William Kenkel, Seth P Finklestein, Thomas M Barchet, JingMei Ren, Mathew Davenport, Martha E Shenton, Zora Kikinis, Mark Nedelman, Craig F Ferris

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125748 (2015)

Traumatic brain injury (TBI) can occur anywhere along the cortical mantel. While the cortical contusions may be random and disparate in their locations, the clinical outcomes are often similar and difficult to explain. Thus a question that arises is,

Externí odkaz: https://doaj.org/article/b0979754dd24455798e96db27ff7013e

New Directions in Treatments Targeting Stroke Recovery

Autor: Seth P. Finklestein, Steven C. Cramer, David Lin

Publikováno v: Lin, David J; Finklestein, Seth P; & Cramer, Steven C. (2018). New Directions in Treatments Targeting Stroke Recovery.. Stroke, 49(12), 3107-3114. doi: 10.1161/strokeaha.118.021359. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9zz3w4qz

Stroke is the leading cause of neurological disability in the U.S. and worldwide. Remarkable advances have been made over the last 20 years in acute vascular treatments to reduce infarct size and improve neurological outcome. Substantially less progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fed5af86854ef17dd664731713f54a
https://doi.org/10.1161/strokeaha.118.021359

Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys

Autor: Douglas L. Rosene, Tara L. Moore, Yuxin Zhou, Veronica Go, Seth P. Finklestein, Michael Chopp, Bethany G E Bowley, Monica A. Pessina, Deniz Sarikaya, Zheng Gang Zhang, Maria Medalla, Benjamin Buller

Publikováno v: Exp Neurol

Cortical injury, such as stroke, causes neurotoxic cascades that lead to rapid death and/or damage to neurons and glia. Axonal and myelin damage in particular, are critical factors that lead to neuronal dysfunction and impair recovery of function aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd8b712ef384479d7a7b77a13aeac9d
https://pubmed.ncbi.nlm.nih.gov/33264634