Zobrazeno 1 - 10
of 561
pro vyhledávání: '"Seth P Lerner"'
Publikováno v:
Journal of Urologic Oncology, Vol 22, Iss 1, Pp 68-77 (2024)
Radical nephroureterectomy (RNU) remains the gold standard for the surgical management of upper tract urothelial carcinoma (UTUC) from the ureterovesical junction to the renal pelvis. However, the removal of the ipsilateral intact kidney causes morbi
Externí odkaz:
https://doaj.org/article/a7e826cebca84aa6b2183682fbd88887
Autor:
Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Yang Yuntao, Yuen San Chan, Danthasinghe Waduge Badrajee Piyarathna, Lacey Elizabeth Dobrolecki, David J. H. Shih, Zhongcheng Shi, Jun Xu, Shixia Huang, Matthew J. Ellis, Andrea B. Apolo, Leomar Y. Ballester, Jianjun Gao, Donna E. Hansel, Yair Lotan, H. Courtney Hodges, Seth P. Lerner, Chad J. Creighton, Arun Sreekumar, W. Jim Zheng, Pavlos Msaouel, Shyam M. Kavuri, Nagireddy Putluri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract SMARCB1 loss has long been observed in many solid tumors. However, there is a need to elucidate targetable pathways driving growth and metastasis in SMARCB1-deficient tumors. Here, we demonstrate that SMARCB1 deficiency, defined as genomic S
Externí odkaz:
https://doaj.org/article/92dacc4a9b18472087b40b7343faadf4
Autor:
Andrew R. DiNardo, Moshe Arditi, Ashish M. Kamat, Kent J. Koster, Santiago Carrero, Tomoki Nishiguchi, Maxim Lebedev, Aaron B. Benjamin, Pablo Avalos, Marisa Lozano, Madeleine G. Moule, Brittany McCune, Baysia Herron, Malik Ladki, Daanish Sheikh, Matthew Spears, Ivan A. Herrejon, Courtney Dodge, Sathish Kumar, Robert W. Hutchison, Theresa U. Ofili, Lynne A. Opperman, Jessica A. Bernard, Seth P. Lerner, George Udeani, Gabriel Neal, Mihai G. Netea, Jeffrey D. Cirillo
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Background A large epidemic, such as that observed with SARS-CoV-2, seriously challenges available hospital capacity, and this would be augmented by infection of healthcare workers (HCW). Bacillus Calmette-Guérin (BCG) is a vaccine against
Externí odkaz:
https://doaj.org/article/dcb9a63f260c439d9bbf3e7bf439dfe9
Autor:
Meenakshi Anurag, Trine Strandgaard, Sung Han Kim, Yongchao Dou, Eva Comperat, Hikmat Al-Ahmadie, Brant A. Inman, Ann Taber, Iver Nordentoft, Jørgen Bjerggaard Jensen, Lars Dyrskjøt, Seth P. Lerner
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109179- (2024)
Summary: Urothelial carcinoma in situ (CIS) is an aggressive phenotype of non-muscle-invasive bladder cancer. Molecular features unique to CIS compared to high-grade papillary tumors are underexplored. RNA sequencing of CIS, papillary tumors, and nor
Externí odkaz:
https://doaj.org/article/421e0ea543b3460ab11bc4bd706a726b
Autor:
Seth P. Lerner, Ian D. Davis
Our understanding of the biology of bladder cancer has advanced remarkably since the second edition of'Fast Facts: Bladder Cancer'was published in 2006. Five new immunotherapies targeting the PD-1 axis were approved in 2016 and 2017 for the treatment
Autor:
Kyle M. Rose, Herney A. Garcia-Perdomo, Trinity J. Bivalacqua, Alfred Witjes, Joan Palou, Peter C. Black, Gary D. Steinberg, Seth P. Lerner, Sima P. Porten, Ashish M. Kamat, Roger Li
Publikováno v:
Société Internationale d’Urologie Journal, Vol 3, Iss 5, Pp 333-339 (2022)
There is a critical need to establish reference response rates following bladder-sparing therapies administered in the setting of bacillus Calmete-Guerin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC). We sought to determine the effi
Externí odkaz:
https://doaj.org/article/09971829f8824781a35b8c6ae94a6e1c
Autor:
Hugo Villanueva, Gabrielle A. Wells, Malachi T. Miller, Mariana Villanueva, Ravi Pathak, Patricia Castro, Michael M. Ittmann, Andrew G. Sikora, Seth P. Lerner
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12570- (2022)
Background: Non-metastatic muscle invasive urothelial bladder cancer (MIBC) has a poor prognosis and standard of care (SOC) includes neoadjuvant cisplatin-based chemotherapy (NAC) combined with cystectomy. Patients receiving NAC have at best
Externí odkaz:
https://doaj.org/article/086cef3693b84d1eb141e689ece5ef1d
Autor:
Brian D. Robinson, Panagiotis J. Vlachostergios, Bhavneet Bhinder, Weisi Liu, Kailyn Li, Tyler J. Moss, Rohan Bareja, Kyung Park, Peyman Tavassoli, Joanna Cyrta, Scott T. Tagawa, David M. Nanus, Himisha Beltran, Ana M. Molina, Francesca Khani, Juan Miguel Mosquera, Evanguelos Xylinas, Shahrokh F. Shariat, Douglas S. Scherr, Mark A. Rubin, Seth P. Lerner, Surena F. Matin, Olivier Elemento, Bishoy M. Faltas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Upper tract urothelial carcinoma (UTUC) is an aggressive cancer and largely uncharacterised cancer. Here, Faltas and colleagues report its distinctive molecular and immune landscape compared to urothelial carcinoma of the bladder and explore the role
Externí odkaz:
https://doaj.org/article/1c54e7d3caaa498c865d65f8cebe16d4
Autor:
Danijel Sikic, Ralph M. Wirtz, Sven Wach, Lars Dyrskjøt, Philipp Erben, Christian Bolenz, Johannes Breyer, Wolfgang Otto, Katherine A. Hoadley, Seth P. Lerner, Markus Eckstein, Arndt Hartmann, Bastian Keck
Publikováno v:
Translational Oncology, Vol 12, Iss 4, Pp 661-668 (2019)
INTRODUCTION: Gender-specific differences have led to the androgen receptor (AR) being considered a possible factor in the pathophysiology of urothelial carcinoma of the bladder (UCB), but the exact role remains unclear. MATERIALS AND METHODS: The as
Externí odkaz:
https://doaj.org/article/07ed23158aca44659eca38a9a94652e4
Publikováno v:
Bladder Cancer. 9:41-48
BACKGROUND: One of the best predictors of positive outcomes in bladder cancer (BC) is pT0 following radical cystectomy (RC). Discordance between clinical and pathologic staging affects decision-making in patients with clinical absence of disease (cT0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08ac20dd5f36052943e9886d17a3dc51
https://doi.org/10.3233/blc-220066
https://doi.org/10.3233/blc-220066