Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Seth M. Tomchik"'
Autor:
Valentina Botero, Seth M. Tomchik
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Neurofibromatosis type 1 (OMIM 162200) affects ~ 1 in 3,000 individuals worldwide and is one of the most common monogenetic neurogenetic disorders that impacts brain function. The disorder affects various organ systems, including the central
Externí odkaz:
https://doaj.org/article/eab0c970f37d4a3996d3c77566b3abd4
Autor:
Sammy Villa, Pankaj Dwivedi, Aaron Stahl, Trent Hinkle, Christopher M. Rose, Donald S. Kirkpatrick, Seth M. Tomchik, Vishva M. Dixit, Fred W. Wolf
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Ribosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free
Externí odkaz:
https://doaj.org/article/f4d96cf394f04c89a580b4833e64ad5a
Autor:
Valentina Botero, Bethany A. Stanhope, Elizabeth B. Brown, Eliza C. Grenci, Tamara Boto, Scarlet J. Park, Lanikea B. King, Keith R. Murphy, Kenneth J. Colodner, James A. Walker, Alex C. Keene, William W. Ja, Seth M. Tomchik
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circui
Externí odkaz:
https://doaj.org/article/9bdfedfd53ef4415959b9f694b37b1af
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2014-2021.e2 (2019)
Summary: Dopaminergic neurons play a key role in encoding associative memories, but little is known about how these circuits modulate memory strength. Here we report that different sets of dopaminergic neurons projecting to the Drosophila mushroom bo
Externí odkaz:
https://doaj.org/article/98ddc56664d040cbb97f414764d7fdef
Autor:
Lanikea B. King, Marta Koch, Keith R. Murphy, Yoheilly Velazquez, William W. Ja, Seth M. Tomchik
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 4, Pp 1083-1093 (2016)
Neurofibromatosis I is a common genetic disorder that results in tumor formation, and predisposes individuals to a range of cognitive/behavioral symptoms, including deficits in attention, visuospatial skills, learning, language development, and sleep
Externí odkaz:
https://doaj.org/article/46416f5a905b4cbbaab92cdaa401ab32
Autor:
Aaron Stahl, Nathaniel C Noyes, Tamara Boto, Valentina Botero, Connor N Broyles, Miao Jing, Jianzhi Zeng, Lanikea B King, Yulong Li, Ronald L Davis, Seth M Tomchik
Publikováno v:
eLife, Vol 11 (2022)
Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity of a circuit, and a major question is what role axonal compartmentalization plays. Axonal compartmentalization may enable localized, pr
Externí odkaz:
https://doaj.org/article/dec195defa834890b9033a0c335f44a0
Autor:
Keith R Murphy, Sonali A Deshpande, Maria E Yurgel, James P Quinn, Jennifer L Weissbach, Alex C Keene, Ken Dawson-Scully, Robert Huber, Seth M Tomchik, William W Ja
Publikováno v:
eLife, Vol 5 (2016)
Food consumption is thought to induce sleepiness. However, little is known about how postprandial sleep is regulated. Here, we simultaneously measured sleep and food intake of individual flies and found a transient rise in sleep following meals. Depe
Externí odkaz:
https://doaj.org/article/a711f2f211ac42659d8194076cf1d1bf
Autor:
Aaron Stahl, Nathaniel C Noyes, Tamara Boto, Valentina Botero, Connor N Broyles, Miao Jing, Jianzhi Zeng, Lanikea B King, Yulong Li, Ronald L Davis, Seth M Tomchik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4501d1ac00269bd3c752b46a22af60be
https://doi.org/10.7554/elife.76712.sa2
https://doi.org/10.7554/elife.76712.sa2
Publikováno v:
Journal of Neurogenetics. 34:36-46
Recent years have witnessed significant progress in understanding how memories are encoded, from the molecular to the cellular and the circuit/systems levels. With a good compromise between brain complexity and behavioral sophistication, the fruit fl
Autor:
Jenifer C Kaldun, Shahnaz R Lone, Ana M Humbert Camps, Cornelia Fritsch, Yves F Widmer, Jens V Stein, Seth M Tomchik, Simon G Sprecher
Publikováno v:
PLoS Biology, Vol 19, Iss 10, p e3001412 (2021)
Alzheimer disease (AD) is one of the main causes of age-related dementia and neurodegeneration. However, the onset of the disease and the mechanisms causing cognitive defects are not well understood. Aggregation of amyloidogenic peptides is a patholo