Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Seth M. Rubin"'
Autor:
Alison K. Barrett, Manisha R. Shingare, Andreas Rechtsteiner, Kelsie M. Rodriguez, Quynh N. Le, Tilini U. Wijeratne, Corbin E. Mitchell, Miles W. Membreno, Seth M. Rubin, Gerd A. Müller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Histone deacetylases (HDACs) play a crucial role in transcriptional regulation and are implicated in various diseases, including cancer. They are involved in histone tail deacetylation and canonically linked to transcriptional repression. Pr
Externí odkaz:
https://doaj.org/article/7a712aae55e44cccbb9dbbd6c0a5b6e1
Autor:
Anushweta Asthana, Parameshwaran Ramanan, Alexander Hirschi, Keelan Z. Guiley, Tilini U. Wijeratne, Robert Shelansky, Michael J. Doody, Haritha Narasimhan, Hinrich Boeger, Sarvind Tripathi, Gerd A. Müller, Seth M. Rubin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The MuvB protein complex regulates genes that are differentially expressed through the cell cycle, yet its precise molecular function has remained unclear. Here the authors reveal MuvB associates with the nucleosome adjacent to the transcription star
Externí odkaz:
https://doaj.org/article/f0c4fe55cb71405cb91f1d9f5b878250
Autor:
Jenny Hsu, Julia Arand, Andrea Chaikovsky, Nancie A. Mooney, Janos Demeter, Caileen M. Brison, Romane Oliverio, Hannes Vogel, Seth M. Rubin, Peter K. Jackson, Julien Sage
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
E2F transcription factors are regulators of cell division and cell fate decisions. Here the authors show that E2F4 is important for proliferation and survival of mouse ESCs, independent of the RB family, and that E2F4 interacts with chromatin regulat
Externí odkaz:
https://doaj.org/article/e3a619fadabb47e3805fe00dc38b37d4
Autor:
Paul J. Vorster, Paul Goetsch, Tilini U. Wijeratne, Keelan Z. Guiley, Laura Andrejka, Sarvind Tripathi, Braden J. Larson, Seth M. Rubin, Susan Strome, Joseph S. Lipsick
Publikováno v:
Biology Open, Vol 9, Iss 5 (2020)
The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progressio
Externí odkaz:
https://doaj.org/article/5af2d70fe94a4b07b07a96c7fd3de521
Autor:
Aimee H. Marceau, Jessica G. Felthousen, Paul D. Goetsch, Audra N. Iness, Hsiau-Wei Lee, Sarvind M. Tripathi, Susan Strome, Larisa Litovchick, Seth M. Rubin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The MuvB complex, which regulates cell cycle dependent gene expression, binds promoter cell cycle genes homology region (CHR) elements. Here the authors solve the structure of LIN54, a component of MuvB, bound to DNA and use it to explain the recogni
Externí odkaz:
https://doaj.org/article/4ce47b47d36e4e24bddd06139f1e4c75
Autor:
Taylor P Enrico, Wayne Stallaert, Elizaveta T Wick, Peter Ngoi, Xianxi Wang, Seth M Rubin, Nicholas G Brown, Jeremy E Purvis, Michael J Emanuele
Publikováno v:
eLife, Vol 10 (2021)
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation,
Externí odkaz:
https://doaj.org/article/7ab2a5562a954f65927013e352987cb1
Autor:
Carmen Schwechheimer, Kassidy Hebert, Sarvind Tripathi, Praveen K Singh, Kyle A Floyd, Elise R Brown, Monique E Porcella, Jacqueline Osorio, Joseph T M Kiblen, Fernando A Pagliai, Knut Drescher, Seth M Rubin, Fitnat H Yildiz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008745 (2020)
Production of an extracellular matrix is essential for biofilm formation, as this matrix both secures and protects the cells it encases. Mechanisms underlying production and assembly of matrices are poorly understood. Vibrio cholerae, relies heavily
Externí odkaz:
https://doaj.org/article/cf898045b4b347c9906856ac86023e93
Autor:
Aimee H Marceau, Caileen M Brison, Santrupti Nerli, Heather E Arsenault, Andrew C McShan, Eefei Chen, Hsiau-Wei Lee, Jennifer A Benanti, Nikolaos G Sgourakis, Seth M Rubin
Publikováno v:
eLife, Vol 8 (2019)
Intrinsically disordered transcription factor transactivation domains (TADs) function through structural plasticity, adopting ordered conformations when bound to transcriptional co-regulators. Many transcription factors contain a negative regulatory
Externí odkaz:
https://doaj.org/article/1c78e530a8bb4355a0853d0cf39cebe0
Autor:
Carrie S. Tambo, Sarvind Tripathi, B. Gayani K. Perera, Dustin J. Maly, Alexander J. Bridges, Gert Kiss, Seth M. Rubin
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 18, iss 2
ACS chemical biology, vol 18, iss 2
Cyclin-dependent kinases (CDKs) are key mediators of cell proliferation and have been a subject of oncology drug discovery efforts for over two decades. Several CDK and activator cyclin family members have been implicated in regulating the cell divis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87712b8a44e6dd7e7c442986bb693967
https://europepmc.org/articles/PMC10029018/
https://europepmc.org/articles/PMC10029018/
B-Myb is a highly conserved member of the vertebrate Myb family of transcription factors that plays a critical role in cell-cycle progression and proliferation. Myb proteins activate Myb-dependent promoters by interacting specifically with Myb bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c494f7f6e9ce0a61f0c800ac3f745fed
https://doi.org/10.1101/2022.06.13.495963
https://doi.org/10.1101/2022.06.13.495963