Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Seth M Weinberg"'
Autor:
Jaaved Mohammed, Neha Arora, Harold S Matthews, Karissa Hansen, Maram Bader, Susan Walsh, John R Shaffer, Seth M Weinberg, Tomek Swigut, Peter Claes, Licia Selleri, Joanna Wysocka
Publikováno v:
eLife, Vol 13 (2024)
Genome-wide association studies (GWAS) identified thousands of genetic variants linked to phenotypic traits and disease risk. However, mechanistic understanding of how GWAS variants influence complex morphological traits and can, in certain cases, si
Externí odkaz:
https://doaj.org/article/2cc1a2d4cf454d649f23f3d5f8c28b50
Autor:
Seth M Weinberg
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279202 (2022)
Mild proximal-to-distal tapering of the fingers is a relatively common trait in humans. When more extreme, finger tapering is a feature observed in many genetic syndromes. The range of variation for finger tapering in the general population is not we
Externí odkaz:
https://doaj.org/article/129543a023604d228ce5f90fd0261711
Autor:
Myoung Keun Lee, Zelda T Dahl, Joel Anderton, Jennifer L Maurer, Mary L Marazita, John R Shaffer, Seth M Weinberg
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271734 (2022)
Mild curvature of the fifth finger (or clinodactyly) is a relatively common trait. While severe forms can cause functional impairment and are a feature of certain congenital syndromes, mild clinodactyly is considered a minor morphological variant. De
Externí odkaz:
https://doaj.org/article/3b98e7cfaa6c4d2aa29678418376d30d
Autor:
Chenxing Liu, Myoung Keun Lee, Sahin Naqvi, Hanne Hoskens, Dongjing Liu, Julie D White, Karlijne Indencleef, Harold Matthews, Ryan J Eller, Jiarui Li, Jaaved Mohammed, Tomek Swigut, Stephen Richmond, Mange Manyama, Benedikt Hallgrímsson, Richard A Spritz, Eleanor Feingold, Mary L Marazita, Joanna Wysocka, Susan Walsh, Mark D Shriver, Peter Claes, Seth M Weinberg, John R Shaffer
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009695 (2021)
Facial morphology is highly variable, both within and among human populations, and a sizable portion of this variation is attributable to genetics. Previous genome scans have revealed more than 100 genetic loci associated with different aspects of no
Externí odkaz:
https://doaj.org/article/dfb0218885724fd78f8a05fb3bc0ef13
Autor:
Debashree Ray, Sowmya Venkataraghavan, Wanying Zhang, Elizabeth J Leslie, Jacqueline B Hetmanski, Seth M Weinberg, Jeffrey C Murray, Mary L Marazita, Ingo Ruczinski, Margaret A Taub, Terri H Beaty
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009584 (2021)
Based on epidemiologic and embryologic patterns, nonsyndromic orofacial clefts- the most common craniofacial birth defects in humans- are commonly categorized into cleft lip with or without cleft palate (CL/P) and cleft palate alone (CP), which are t
Externí odkaz:
https://doaj.org/article/90525a7ed9d84f02a38684f2479cc4de
Autor:
Hanne Hoskens, Dongjing Liu, Sahin Naqvi, Myoung Keun Lee, Ryan J Eller, Karlijne Indencleef, Julie D White, Jiarui Li, Maarten H D Larmuseau, Greet Hens, Joanna Wysocka, Susan Walsh, Stephen Richmond, Mark D Shriver, John R Shaffer, Hilde Peeters, Seth M Weinberg, Peter Claes
Publikováno v:
PLoS Genetics, Vol 17, Iss 5, p e1009528 (2021)
The analysis of contemporary genomic data typically operates on one-dimensional phenotypic measurements (e.g. standing height). Here we report on a data-driven, family-informed strategy to facial phenotyping that searches for biologically relevant tr
Externí odkaz:
https://doaj.org/article/14d3807022064bf8acadeccc7dc4dd49
Autor:
Sara H Katsanis, Peter Claes, Megan Doerr, Robert Cook-Deegan, Jessica D Tenenbaum, Barbara J Evans, Myoung Keun Lee, Joel Anderton, Seth M Weinberg, Jennifer K Wagner
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0257923 (2021)
Facial imaging and facial recognition technologies, now common in our daily lives, also are increasingly incorporated into health care processes, enabling touch-free appointment check-in, matching patients accurately, and assisting with the diagnosis
Externí odkaz:
https://doaj.org/article/1559eb0d08574a1c9ff1650a62bf88d5
Autor:
Carolyn R Hodges-Simeon, Graham Albert, George B Richardson, Timothy S McHale, Seth M Weinberg, Michael Gurven, Steven J C Gaulin
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0240284 (2021)
Sexual selection researchers have traditionally focused on adult sex differences; however, the schedule and pattern of sex-specific ontogeny can provide insights unobtainable from an exclusive focus on adults. Recently, it has been debated whether fa
Externí odkaz:
https://doaj.org/article/045737bd20f24579aa8412e6fe5ab0f8
Autor:
Katherine Neiswanger, Nandita Mukhopadhyay, Shwetha Rajagopalan, Elizabeth J Leslie, Carla A Sanchez, Jacqueline T Hecht, Iêda M Orioli, Fernando A Poletta, Javier Enríquez de Salamanca, Seth M Weinberg, Mary L Marazita
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230534 (2020)
Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial bi
Externí odkaz:
https://doaj.org/article/dd806ce1c31549b188c19881c86818ad
Autor:
Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L Marazita, John R Shaffer, Kerrie McAloney, Shu-Hua Xu, Li Jin, Sijia Wang, Femke MS de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei Zhurov, Sarah Lewis, Gemma C Sharp, Lavinia Paternoster, Holly Thompson, Rolando Gonzalez-Jose, Maria Catira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, André G Uitterlinden, M Arfan Ikram, Eppo Wolvius, Steven A Kushner, Tamar EC Nijsten, Robert-Jan TS Palstra, Stefan Boehringer, Sarah E Medland, Kun Tang, Andres Ruiz-Linares, Nicholas G Martin, Timothy D Spector, Evie Stergiakouli, Seth M Weinberg, Fan Liu, Manfred Kayser, On behalf of the International Visible Trait Genetics (VisiGen) Consortium
Publikováno v:
eLife, Vol 8 (2019)
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes qu
Externí odkaz:
https://doaj.org/article/cb141e48e70148ee8bc2e91adf5b6c6e