Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Seth J. Weir"'
Autor:
Daniel Shiloh Malawsky, Seth J. Weir, Jennifer Karin Ocasio, Benjamin Babcock, Taylor Dismuke, Abigail H. Cleveland, Andrew M. Donson, Rajeev Vibhakar, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Malawsky, Weir et al. compare medulloblastomas that form in mice engineered to express SmoM2, a constitutively active component of the Sonic hedgehog signaling pathway, starting in either neural progenitor or stem cells. Medulloblastomas in the two m
Externí odkaz:
https://doaj.org/article/605864249f4542d69b3f957f5ac481cd
Autor:
Jennifer Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although the hedgehog (HH) pathway is known to be deregulated in medulloblastoma, inhibitors of the pathway have shown disappointing clinical benefit. Using single-cell sequencing in a mouse model of the disease, the authors show that the response to
Externí odkaz:
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Jennifer Karin Ocasio, Benjamin Babcock, Daniel Malawsky, Seth J. Weir, Lipin Loo, Jeremy M. Simon, Mark J. Zylka, Duhyeong Hwang, Taylor Dismuke, Marina Sokolsky, Elias P. Rosen, Rajeev Vibhakar, Jiao Zhang, Olivier Saulnier, Maria Vladoiu, Ibrahim El-Hamamy, Lincoln D. Stein, Michael D. Taylor, Kyle S. Smith, Paul A. Northcott, Alejandro Colaneri, Kirk Wilhelmsen, Timothy R. Gershon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c9c57a0e4ea24207a669b99052c30e34
Autor:
Michael D. Taylor, Marina Sokolsky, Daniel S Malawsky, Benjamin Babcock, Duhyeong Hwang, Elias P. Rosen, Jiao Zhang, Jeremy M. Simon, Lipin Loo, Ibrahim El-Hamamy, Jennifer Ocasio, Kyle S. Smith, Rajeev Vibhakar, Mark J. Zylka, Maria C. Vladoiu, Timothy R. Gershon, Olivier Saulnier, Seth J. Weir, Taylor Dismuke, Kirk C. Wilhelmsen, Alejandro Colaneri, Paul A. Northcott, Lincoln Stein
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular diversity within tumors and reduced lineage commitment can undermine targeted th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913bf88d556273bc70f19ddff9003a89
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
https://doaj.org/article/2fac3f5447844cbea3e21cfcf9b5423c
Autor:
Daniel S Malawsky, Martin Sill, Bridget Sanford, Andrew M. Donson, Siddhartha Mitra, Sujatha Venkataraman, Seth J. Weir, Kent Riemondy, Nicholas Willard, Andrea Griesinger, Rajeev Vibhakar, Timothy R. Gershon, Todd C. Hankinson, Robert J. Wechsler-Reya, Jay R. Hesselberth, Alexandra Garancher, Anandani Nellan, Jennifer Ocasio, Nicholas K. Foreman, Vladimir Amani, Michael H. Handler
Publikováno v:
Neuro Oncol
Background Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells and associated immune cells contribute to disease progression. We aimed to determine the influence of neoplastic and immune cell diversity on MB biology in patient s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbaf2ff178394dc8a552bbfe5677a870
https://europepmc.org/articles/PMC8804892/
https://europepmc.org/articles/PMC8804892/
Autor:
Seth J. Weir, Andrew M. Donson, Taylor Dismuke, Daniel S Malawsky, Abigail H. Cleveland, Jennifer Ocasio, Kirk C. Wilhelmsen, Benjamin Babcock, Timothy R. Gershon, Rajeev Vibhakar
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
It is unclear why medulloblastoma patients receiving similar treatments experience different outcomes. Transcriptomic profiling identified subgroups with different prognoses, but in each subgroup, individuals remain at risk of incurable recurrence. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54eff4892ecd5f37eefd36fc3addae8
http://europepmc.org/articles/PMC8139976
http://europepmc.org/articles/PMC8139976
Autor:
Bernard E. Weissman, Liza Makowski, Tigist Y. Tamir, Stephanie A. Montgomery, Seth J. Weir, Travis P. Schrank, Tuong T. Nguyen, Scott H. Randell, Travis S. Ptacek, D. Neil Hayes, Jeremy M. Simon, Kathleen M. Mulvaney, Brittany M. Bowman, Michael B. Major, Xiaoxin L Chen, Ryan M. Murphy
Publikováno v:
J Pathol
Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441e71dc1a72cc8706ac8773e1a87bb8
https://pubmed.ncbi.nlm.nih.gov/32619021
https://pubmed.ncbi.nlm.nih.gov/32619021
BIMG-18. ELEVATED CYSTATHIONINE IN MEDULLOBLASTOMA DEMONSTRATES TUMOR-SPECIFIC METHIONINE METABOLISM
Autor:
Ben Babcock, Elias P. Rosen, Jeffrey M. Macdonald, Seth J. Weir, Stuart Parnham, Andrey P. Tikunov
Publikováno v:
Neuro-oncology Advances
We investigated tumor-specific metabolism medulloblastoma using a non-biased MS-imaging screen and identified a pattern of methionine flux that may present a therapeutic opportunity. We studied brain tumors that form in mice genetically engineered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b192b3a1568836b5273e2b632b665cad
https://doi.org/10.1093/noajnl/vdab024.017
https://doi.org/10.1093/noajnl/vdab024.017
Autor:
Priscila F. Siesser, Emily M. Cousins, Dennis Goldfarb, Erica W. Cloer, Nikolay V. Dokholyan, David D. Mowrey, Michael B. Major, Joseph S. Harrison, Seth J. Weir
Publikováno v:
Molecular and Cellular Biology. 38
Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a prosurvival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a recent gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb10f6ed405082d5dde4cef2669bac9
https://doi.org/10.1128/mcb.00644-17
https://doi.org/10.1128/mcb.00644-17
Publikováno v:
Cancer Research. 78:5856-5856
Background: The Nrf2/Keap1 pathway is critical for human cells to respond to oxidative stress. In basal conditions the Keap1 homodimer is bound to Nrf2 in the cytoplasm. When stressed, Keap1 releases Nrf2 which translocates into the nucleus, binds th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec10e301af3831d76146d77c86195cfd
https://doi.org/10.1158/1538-7445.am2018-5856
https://doi.org/10.1158/1538-7445.am2018-5856