Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Seth H. Weinberg"'
Autor:
Sonja Langthaler, Christian Zumpf, Theresa Rienmüller, Niroj Shrestha, Julia Fuchs, Rui Zhou, Brigitte Pelzmann, Klaus Zorn-Pauly, Eleonore Fröhlich, Seth H. Weinberg, Christian Baumgartner
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
IntroductionAdvances in molecular targeting of ion channels may open up new avenues for therapeutic approaches in cancer based on the cells’ bioelectric properties. In addition to in-vitro or in-vivo models, in silico models can provide deeper insi
Externí odkaz:
https://doaj.org/article/3111c1c30d0e4ced9bbeeb33ac65fe04
Autor:
Shreyas U. Hirway, Seth H. Weinberg
Publikováno v:
Computational and Systems Oncology, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract Cancer is a life‐threatening process that stems from genetic mutations in cells, which leads to the formation of tumors, and is a major cause of deaths in the United States, with secondary metastasis being a major driver of fatality. The d
Externí odkaz:
https://doaj.org/article/18c334334b284e3ab38fdac91e540135
Publikováno v:
Computational and Systems Oncology, Vol 1, Iss 4, Pp n/a-n/a (2021)
Abstract Epithelial‐mesenchymal transition (EMT) is the transdifferentiation of epithelial cells to a mesenchymal phenotype, in which cells lose epithelial‐like cell–cell adhesions and gain mesenchymal‐like enhanced contractility and mobility
Externí odkaz:
https://doaj.org/article/94cca344d0a04abc9464f268df2f99c8
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Electrical conduction in cardiac ventricular tissue is regulated via sodium (Na+) channels and gap junctions (GJs). We and others have recently shown that Na+channels preferentially localize at the site of cell-cell junctions, the intercalated disc (
Externí odkaz:
https://doaj.org/article/e2b6d5a06aa042f18d7e7d9758a7bdf8
Autor:
Sonja Langthaler, Jasmina Lozanović Šajić, Theresa Rienmüller, Seth H. Weinberg, Christian Baumgartner
Publikováno v:
Cells, Vol 11, Iss 2, p 239 (2022)
The mathematical modeling of ion channel kinetics is an important tool for studying the electrophysiological mechanisms of the nerves, heart, or cancer, from a single cell to an organ. Common approaches use either a Hodgkin–Huxley (HH) or a hidden
Externí odkaz:
https://doaj.org/article/fb0d4fbda991430e887015bbd2f04c95
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is essential for tissue patterning and organization, and it has also
Externí odkaz:
https://doaj.org/article/7d7b855dc21e46f2bd4f85333d81558f
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 2016, Iss Suppl. 1, Pp 17-26 (2016)
Externí odkaz:
https://doaj.org/article/0fb479052bd143b5a877df24b7b669dd
Autor:
Seth H. Weinberg
Publikováno v:
Clinical Medicine Insights: Cardiology, Vol 2016, Iss Suppl. 1, Pp 1-15 (2016)
Externí odkaz:
https://doaj.org/article/dc1753f5621341cbb90b6601196a6d35
Autor:
Nicolae Moise, Seth H. Weinberg
Publikováno v:
Biophysical Journal. 122:1613-1632
A data-assimilation approach to predict population dynamics during epithelial-mesenchymal transition
Autor:
Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Christopher A. Lemmon, Seth H. Weinberg
Publikováno v:
Biophysical Journal. 121:3061-3080
Epithelial-mesenchymal transition (EMT) is a biological process that plays a central role in embryonic development, tissue regeneration, and cancer metastasis. Transforming growth factor-β (TGFβ) is a potent inducer of this cellular transition, com