Zobrazeno 1 - 10
of 519
pro vyhledávání: '"Seth Blackshaw"'
Autor:
Kurt Weir, Natasha Vega, Veronica F. Busa, Ben Sajdak, Les Kallestad, Dana Merriman, Krzysztof Palczewski, Joseph Carroll, Seth Blackshaw
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Torpor encompasses diverse adaptations to extreme environmental stressors such as hibernation, aestivation, brumation, and daily torpor. Here we introduce StrokeofGenus, an analytic pipeline that identifies distinct transcriptomic states and
Externí odkaz:
https://doaj.org/article/0c7f1b6a2c8441f9b18eed9963bf5ab6
Autor:
Henri Leinonen, Jianye Zhang, Laurence M. Occelli, Umair Seemab, Elliot H. Choi, Luis Felipe L.P. Marinho, Janice Querubin, Alexander V. Kolesnikov, Anna Galinska, Katarzyna Kordecka, Thanh Hoang, Dominik Lewandowski, Timothy T. Lee, Elliott E. Einstein, David E. Einstein, Zhiqian Dong, Philip D. Kiser, Seth Blackshaw, Vladimir J. Kefalov, Marcin Tabaka, Andrzej Foik, Simon M. Petersen-Jones, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Inherited retinopathies are devastating diseases that in most cases lack treatment options. Disease-modifying therapies that mitigate pathophysiology regardless of the underlying genetic lesion are desirable due to the diversity of mutations
Externí odkaz:
https://doaj.org/article/b5b9cf370c114fd1b6b378a34d01cbf7
Autor:
Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-17 (2024)
Abstract Background Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 over
Externí odkaz:
https://doaj.org/article/57aa4877bd6841eeb1d7825c31059ce8
Autor:
Cheng Qian, Ying Xin, Cheng Qi, Hui Wang, Bryan C. Dong, Donald J. Zack, Seth Blackshaw, Samer Hattar, Feng-Quan Zhou, Jiang Qian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Previous studies of neuronal survival have primarily focused on identifying intrinsic mechanisms controlling the process. This study explored how intercellular communication contributes to retinal ganglion cell (RGC) survival following optic
Externí odkaz:
https://doaj.org/article/b1cda4bead69404db2565077129f3d56
Autor:
Pin Lyu, Maria Iribarne, Dmitri Serjanov, Yijie Zhai, Thanh Hoang, Leah J. Campbell, Patrick Boyd, Isabella Palazzo, Mikiko Nagashima, Nicholas J. Silva, Peter F. Hitchcock, Jiang Qian, David R. Hyde, Seth Blackshaw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Following acute retinal damage, zebrafish possess the ability to regenerate all neuronal subtypes through Müller glia (MG) reprogramming and asymmetric cell division that produces a multipotent Müller glia-derived neuronal progenitor cell
Externí odkaz:
https://doaj.org/article/71690f1b09a744288c5a191665a5f721
Autor:
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila, the clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks and cyclically regulates sleep and
Externí odkaz:
https://doaj.org/article/8234d36b2f9147ce8f1a2a29b89103bf
Autor:
Clayton P. Santiago, PhD, MS, Megan Y. Gimmen, BSc, Yuchen Lu, BSc, Minda M. McNally, MS, Leighton H. Duncan, MA, BSc, Tyler J. Creamer, PhD, Linda D. Orzolek, MS, Seth Blackshaw, PhD, Mandeep S. Singh, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 4, Pp 100335- (2023)
Purpose: Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery, and the molecular changes leading to this aberrant wound healing process are currently unknown. Our ultimate goal is to study PVR path
Externí odkaz:
https://doaj.org/article/33c3d0e044e2446db6f33df651349f50
Autor:
Dong Won Kim, Kevin J. Tu, Alice Wei, Ashley J. Lau, Anabel Gonzalez-Gil, Tianyu Cao, Kerstin Braunstein, Jonathan P. Ling, Juan C. Troncoso, Philip C. Wong, Seth Blackshaw, Ronald L. Schnaar, Tong Li
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amongst risk alleles associated with late-onset Alzheimer’s disease (AD), those that converged on the regulation of microglia activity have emerged as central to disease progression. Yet, how canonical amyloid-β (Aβ) and tau p
Externí odkaz:
https://doaj.org/article/ec442a6e4b7a4771a917c198f063d4ef
Autor:
Jonathan P. Ling, Alexei M. Bygrave, Clayton P. Santiago, Rogger P. Carmen-Orozco, Vickie T. Trinh, Minzhong Yu, Yini Li, Ying Liu, Kyra D. Bowden, Leighton H. Duncan, Jeong Han, Kamil Taneja, Rochinelle Dongmo, Travis A. Babola, Patrick Parker, Lizhi Jiang, Patrick J. Leavey, Jennifer J. Smith, Rachel Vistein, Megan Y. Gimmen, Benjamin Dubner, Eric Helmenstine, Patric Teodorescu, Theodoros Karantanos, Gabriel Ghiaur, Patrick O. Kanold, Dwight Bergles, Ben Langmead, Shuying Sun, Kristina J. Nielsen, Neal Peachey, Mandeep S. Singh, W. Brian Dalton, Fatemeh Rajaii, Richard L. Huganir, Seth Blackshaw
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Precise and reliable gene delivery remains technically challenging. Here, the authors show that rationally designed frameshifting splicing can be used to express genes only in targeted cell types, with the potential to enhance the specificity AAV gen
Externí odkaz:
https://doaj.org/article/d3c897c79c354a7aba8f34a9159e9fad
Autor:
Elliot H. Choi, Susie Suh, Andrzej T. Foik, Henri Leinonen, Gregory A. Newby, Xin D. Gao, Samagya Banskota, Thanh Hoang, Samuel W. Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C. Lyon, David R. Liu, Krzysztof Palczewski
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Leber congenital amaurosis is caused by mutations in RPE65 and leads to retinal degeneration in children. Here, the authors show that in vivo base editing can prolong the survival of cone photoreceptors and rescue their function in a mouse model of t
Externí odkaz:
https://doaj.org/article/ffc071797e4f4fa694375352a34ae7c4