Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Seth B. Herzon"'
Autor:
Michael W. Dougherty, Rafael Valdés-Mas, Kevin M. Wernke, Raad Z. Gharaibeh, Ye Yang, Jason O. Brant, Alberto Riva, Marcus Muehlbauer, Eran Elinav, Jens Puschhof, Seth B. Herzon, Christian Jobin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 43, Iss , Pp 100918- (2023)
Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models,
Externí odkaz:
https://doaj.org/article/be1c3e9769744513b42cb4dbc20b7f19
Autor:
Seth B. Herzon
Publikováno v:
ACS Central Science, Vol 6, Iss 6, Pp 833-835 (2020)
Externí odkaz:
https://doaj.org/article/65f3c07c86f34b6cb86b0a778322abc4
Autor:
Xiaoshen Ma, Seth B. Herzon
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 2259-2265 (2018)
We show that cobalt bis(acetylacetonate) [Co(acac)2], tert-butyl hydroperoxide (TBHP), and triethylsilane (Et3SiH) constitute an inexpensive, general, and practical reagent combination to initiate a broad range of Markovnikov-selective alkene hydrofu
Externí odkaz:
https://doaj.org/article/7a1c736df202433ebeffbf3dacfd5a77
Autor:
Madeline C. Frischling, Seth B. Herzon
Publikováno v:
Organic Letters. 25:3723-3727
Autor:
Ian Tingyung Hsu, Seth B. Herzon
Publikováno v:
The Journal of Organic Chemistry. 88:2221-2244
Publikováno v:
J Am Chem Soc
We describe a stereocontrolled synthesis of 3, the fully glycosylated monomeric unit of the dimeric cytotoxic bacterial metabolite (−)-lomaiviticin A (2). A novel strategy involving convergent, site- and stereoselective coupling of the β,γ-unsatu
Publikováno v:
J Org Chem
Recent efforts in the field of carbohydrate chemistry have focused on the site- and stereocontrolled synthesis of O-glycosides derived from acceptors bearing multiple hydroxyl substituents. By comparison, there are few examples of the site-selective
Publikováno v:
Accounts of Chemical Research.
Publikováno v:
Natural Product Reports.
This review summarizes the syntheses of ten representative families of natural products that contain tricyclic bridgehead carbon centers (TBCCs). We organize the approaches around the five strategies shown to aid future synthetic endeavors.
Autor:
Victor S. Batista, Zechun Wang, Martin Tomanik, Facheng Guo, Zhi Xu, Ke R. Yang, Seth B. Herzon
Publikováno v:
The Journal of Organic Chemistry. 86:17011-17035
We detail the development of the first enantioselective synthetic route to euonyminol (1), the most heavily oxidized member of the dihydro-β-agarofuran sesquiterpenes and the nucleus of the macrocyclic alkaloids known as the cathedulins. Key steps i