Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Seth B Coffelt"'
Autor:
Robin M H Rumney, Seth B Coffelt, Terence A Neale, Sandeep Dhayade, Gillian M Tozer, Gaynor Miller
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188591 (2017)
CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number of TAMs and
Externí odkaz:
https://doaj.org/article/1c51ee38ebc64283b5477a7cc56b5b49
Autor:
Saumya Kumar, Afonso P. Basto, Filipa Ribeiro, Silvia C. P. Almeida, Patricia Campos, Carina Peres, Nadia Pulvirenti, Sarwah Al-Khalidi, Anna Kilbey, Jimena Tosello, Eliane Piaggio, Momtchilo Russo, Margarida Gama-Carvalho, Seth B. Coffelt, Ed W. Roberts, Jens Geginat, Helena F. Florindo, Luis Graca
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-21 (2024)
Abstract Effective antibody responses are essential to generate protective humoral immunity. Different inflammatory signals polarize T cells towards appropriate effector phenotypes during an infection or immunization. Th1 and Th2 cells have been asso
Externí odkaz:
https://doaj.org/article/b1ab6f0616b246af8630d5bef2fc7871
Autor:
Amy Dawson, Martha M. Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E. M. Hopcroft, Mary T. Scott, Pablo Baquero, Karen Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B. Coffelt, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour progression. Here we use a chimeric mouse model of chronic myeloid leukaemia (CML) and hu
Externí odkaz:
https://doaj.org/article/8f93c354e91945c2be6407a9da014cb7
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39592 (2012)
BACKGROUND:The use of bone marrow-derived human multipotent stromal cells (hMSC) in cell-based therapies has dramatically increased in recent years, as researchers have exploited the ability of these cells to migrate to sites of tissue injury, inflam
Externí odkaz:
https://doaj.org/article/a2e82ba0149445dea129945470065c61
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42217 (2012)
The leading cause of pregnancy-associated mortality and morbidity is pre-eclampsia (PE). Although information regarding the etiology of this disease is scant, its pathophysiology is characterized by abnormal placentation, endothelial dysfunction as w
Externí odkaz:
https://doaj.org/article/ae5abf31b7084a939847d94b70662364
Autor:
Juan F. Quintana, Matthew C. Sinton, Praveena Chandrasegaran, Agatha Nabilla Lestari, Rhiannon Heslop, Bachar Cheaib, John Ogunsola, Dieudonne Mumba Ngoyi, Nono-Raymond Kuispond Swar, Anneli Cooper, Neil A. Mabbott, Seth B. Coffelt, Annette MacLeod
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection usi
Externí odkaz:
https://doaj.org/article/9a96c210c22f4f58b0bd9fc2f4ee75ce
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/30430bb9a29a49858c0a5f992cab0084
Autor:
Daniel J. Murphy, Jennifer P. Morton, Owen J. Sansom, Seth B. Coffelt, Leo M. Carlin, Andrew V. Biankin, William Clark, Colin Nixon, Katarina Gyuraszova, Saadia A. Karim, Curtis Rink, Sarah Neidler, Robin Shaw, Rosanna Upstill-Goddard, Björn Kruspig, Sarah Laing, Ann Hedley, Declan Whyte, Robert Wiesheu, Ximena Raffo-Iraolagoitia, Tiziana Monteverde, Nathiya Muthalagu
Spreadsheet of genes co-regulated by MYC & Miz1 in KMC PDAC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85445eb0df2a3b684d67a96845226776
https://doi.org/10.1158/2159-8290.22535632.v1
https://doi.org/10.1158/2159-8290.22535632.v1
Autor:
Aline B. Scandurro, Elizabeth S. Danka, Kevin J. Zwezdaryk, Suzanne L. Tomchuck, Seth B. Coffelt
Supplementary Data from Leucine Leucine-37 Uses Formyl Peptide Receptor–Like 1 to Activate Signal Transduction Pathways, Stimulate Oncogenic Gene Expression, and Enhance the Invasiveness of Ovarian Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5193e5551f0983ced650b101427e7a
https://doi.org/10.1158/1541-7786.22519420.v1
https://doi.org/10.1158/1541-7786.22519420.v1
Autor:
Claire E. Lewis, Yvonne Reiss, Karl H. Plate, Craig Murdoch, Subhra K. Biswas, Carmen Urbich, Sunil Patel, Michele De Palma, Alexander Scholz, Andrea O. Tal, Seth B. Coffelt
TIE2-expressing monocytes/macrophages (TEM) are a highly proangiogenic subset of myeloid cells in tumors. Here, we show that circulating human TEMs are already preprogrammed in the circulation to be more angiogenic and express higher levels of such p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e85e2021e3d09bf23502327a5fd2d230
https://doi.org/10.1158/0008-5472.c.6500303
https://doi.org/10.1158/0008-5472.c.6500303