Výsledky vyhledávání - "Seth A. Townsend"

Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons

Autor: Robert H. Brown, Robert Langer, Martin Michael Peter Schulz, Gilad D. Evrony, Frank X. Gu, Seth A. Townsend

Publikováno v: Biomaterials. 28:5176-5184

The use of nanoparticles for targeted drug delivery is often facilitated by specific conjugation of functional targeting molecules to the nanoparticle surface. We compared different biotin-binding proteins (avidin, streptavidin, or neutravidin) as cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574e531699cd6ad27bfdb45d977544fe
https://doi.org/10.1016/j.biomaterials.2007.08.011

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Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells

Autor: Lino Ferreira, Jason A. Burdick, Sharon Gerecht, Robert Langer, Seth A. Townsend, Gordana Vunjak-Novakovic

Publikováno v: Proceedings of the National Academy of Sciences. 104:11298-11303

Control of self-renewal and differentiation of human ES cells (hESCs) remains a challenge. This is largely due to the use of culture systems that involve poorly defined animal products and do not mimic the normal developmental milieu. Routine protoco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd59cd39d2c4d85d371b7de27baa376d
https://doi.org/10.1073/pnas.0703723104

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Critical Role for the α-1B Adrenergic Receptor at the Sympathetic Neuroeffector Junction

Autor: Shakil A. Khan, Christoper A. Lemmon, Susanna Cotecchia, Albert S. Jung, Lili A. Barouch, Artin A. Shoukas, Yen Shi Gillian Hoe, Kwangh Ho Lee, Daniel Nyhan, Rafael Y. Lefkowitz, Dan E. Berkowitz, Joshua M. Hare, Robert W. Harrison, Seth A. Townsend

Publikováno v: Hypertension. 44:776-782

The α-1 adrenergic receptors (α 1 ARs) are critical in sympathetically mediated vasoconstriction. The specific role of each α 1 AR subtype in regulating vasoconstriction remains highly controversial. Limited pharmacological studies suggest that di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d675aeb0839ec91f9262711a6268e44
https://doi.org/10.1161/01.hyp.0000145405.01113.0e

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A porous photocurable elastomer for cell encapsulation and culture

Autor: Christiaan Nijst, Sharon Gerecht, Seth A. Townsend, Jason W. Nichol, Joost P. Bruggeman, Robert Langer, Heather M Pressler, Han Zhu

Publikováno v: Biomaterials. 28(32)

Encapsulating cells within a polymer matrix creates a three-dimensional (3D) scaffold that may more accurately represent the native microenvironment and cell organization. Here we report a porous scaffold prepared from a photocurable elastomer, poly(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664c1b300ff4801b5195e7c03563df55
https://pubmed.ncbi.nlm.nih.gov/17692371

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FDA advisory committee meeting outcomes

Autor: Navjot Singh, Jeffrey F Smith, Philip Ma, Seth A Townsend

Publikováno v: Nature Reviews Drug Discovery. 11:513-514

This analysis of the outcomes of advisory committee meetings held by the US Food and Drug Administration (FDA) over the past decade investigates issues such as the consistency between advisory committee votes and FDA approval decisions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68219e5e6a26a1648a79283a26d6fb94
https://doi.org/10.1038/nrd3747

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