Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Seth A. Gilbert"'
Autor:
Michael T. McCabe, Caretha L. Creasy, Ashley M. Hughes, Kimberly N. Smitheman, Anthony Della Pietra, Kimberly E. Allen, Sara H. Thrall, Martin Brandt, Gopinath Ganji, Elsie Diaz, Edward Dul, Melissa B. Pappalardi, Ryan G. Kruger, Peter J. Tummino, Heidi M. Ott, Wendy S. Halsey, Yong Jiang, Alan P. Graves, Seth A. Gilbert, Stephanie Chen, Benjamin J. Schwartz
Publikováno v:
Epigenomics. 4(3)
Trimethylation of histone H3 on lysine 27 (H3K27me3) is a repressive posttranslational modification mediated by the histone methyltransferase EZH2. EZH2 is a component of the polycomb repressive complex 2 and is overexpressed in many cancers. In B-ce
Autor:
William H. Miller, Stuart Paul Romeril, Jesus R. Medina, Valery Sudakin, Sridhar K. Rabindran, Dirk A. Heerding, Mark A. Bobko, Jeffrey M. Axten, Celine Duquenne, Antony Chadderton, Melissa Dumble, Seth A. Gilbert, Charles W. Blackledge, Arthur Shu, Daryl A. Scherzer, Nino Campobasso, Christopher Becker, Hong Xiang, William Hoi Hong Li, Pat Brady, Qi Liu, Paris Ward, Christine M. Gardiner, Seth W. Grant, Yanhong Feng
Publikováno v:
Journal of medicinal chemistry. 54(6)
Phosphoinositide-dependent protein kinase-1(PDK1) is a master regulator of the AGC family of kinases and an integral component of the PI3K/AKT/mTOR pathway. As this pathway is among the most commonly deregulated across all cancers, a selective inhibi
Autor:
Richard Wooster, Kristin K. Brown, Deping Chai, Mariela Colón, Jennifer L. Ariazi, Chad Quinn, Sharon Sweitzer, Nino Campobasso, Subhas J. Chakravorty, Gregory M. Waitt, Tony Shaw, Kevin J. Duffy, Roland S. Annan, Jacques Briand, Nathan Gaul, Christian S. Sherk, Elizabeth A. Davenport, Jeanelle McSurdy-Freed, Kelvin Nurse, Anthony J. Jurewicz, Dean E. McNulty, Gilbert F. Scott, Angela Smallwood, James P. Villa, Hong Lu, Paru Nuthulaganti, Julia Billiard, Christopher S Dodson, Jessica L. Schneck, Lisa Miller, Seth A. Gilbert
Publikováno v:
Cancer Research. 73:5418-5418
Many cancer cells generate energy by rapidly converting glucose to lactate in the cytosol, a process termed aerobic glycolysis. This metabolic phenotype is recognized as one of the hallmarks of cancer and is enabled by lactate dehydrogenase (LDH), wh
Autor:
Jeffrey R. Jackson, Catherine A. Oleykowski, David Sutton, Ramona Plant, Hong Lu, Kurt R. Auger, Jamin Wang, Chiu-Mei Sung, Melody Diamond, Richard Wooster, Jeffrey D. Carson, Steven D. Knight, Richard R. Gontarek, Mary Ann Hardwicke, Christine M. Gardiner, Glenn S. Van Aller, Seth A. Gilbert, Peter J. Tummino, Lusong Luo, Dashyant Dhanak
Publikováno v:
Molecular Cancer Therapeutics. 8:C63-C63
The phosphoinositide 3-kinase (PI3K) pathway is among the most commonly activated pathways in human cancer. The biological role of PI3K in growth and survival of cancer cells and the prevalence of activating mutations in human cancers are well docume
Autor:
Joel Greshock, Mariela Colón, Chad Quinn, Gilbert F. Scott, Gordon B. Mills, Richard Wooster, Gregory M. Waitt, Shaw Antony N, Roland S. Annan, Junping Jing, Kevin J. Duffy, Lisa A. Orband-Miller, Jacques Briand, Hong Lu, Julia Billiard, Seth A. Gilbert, Jeanelle McSurdy-Freed, Christopher S Dodson, Jessica L. Schneck, Jennifer B. Dennison, Deping Chai
Publikováno v:
Cancer & Metabolism
Background Most normal cells in the presence of oxygen utilize glucose for mitochondrial oxidative phosphorylation. In contrast, many cancer cells rapidly convert glucose to lactate in the cytosol, a process termed aerobic glycolysis. This glycolytic