Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Seth A Brodie"'
Autor:
Jianxin Shi, Xing Hua, Bin Zhu, Sarangan Ravichandran, Mingyi Wang, Cu Nguyen, Seth A Brodie, Alessandro Palleschi, Marco Alloisio, Gianluca Pariscenti, Kristine Jones, Weiyin Zhou, Aaron J Bouk, Joseph Boland, Belynda Hicks, Adam Risch, Hunter Bennett, Brian T Luke, Lei Song, Jubao Duan, Pengyuan Liu, Takashi Kohno, Qingrong Chen, Daoud Meerzaman, Crystal Marconett, Ite Laird-Offringa, Ian Mills, Neil E Caporaso, Mitchell H Gail, Angela C Pesatori, Dario Consonni, Pier Alberto Bertazzi, Stephen J Chanock, Maria Teresa Landi
Publikováno v:
PLoS Medicine, Vol 13, Iss 12, p e1002162 (2016)
BACKGROUND:Lung adenocarcinoma (LUAD) is the most common histologic subtype of lung cancer and has a high risk of distant metastasis at every disease stage. We aimed to characterize the genomic landscape of LUAD and identify mutation signatures assoc
Externí odkaz:
https://doaj.org/article/30013d5f9ba74edfbd73493a4b002027
Autor:
Seth A Brodie, Courtney Lombardo, Ge Li, Jeanne Kowalski, Khanjan Gandhi, Shaojin You, Fadlo R Khuri, Adam Marcus, Paula M Vertino, Johann C Brandes
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107124 (2014)
Aberrant promoter DNA methylation can serve as a predictive biomarker for improved clinical responses to certain chemotherapeutics. One of the major advantages of methylation biomarkers is the ease of detection and clinical application. In order to i
Externí odkaz:
https://doaj.org/article/cc4fe30868cc44918af2125cbede5c97
Autor:
Johann C. Brandes, Paula M. Vertino, Fadlo R. Khuri, Gabriel L. Sica, Jeanne Kowalski, Khanjan Gandhi, Madhusmita Behera, Suresh S. Ramalingam, Hyunseok Kang, Adam El-Kommos, Ge Li, Seth A. Brodie
PDF file - 47K, Differentially methylated genes with beta values (3KT vs carcinogen exposed).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f977294117171921e7157ba5214b38
https://doi.org/10.1158/1940-6207.22524924
https://doi.org/10.1158/1940-6207.22524924
Autor:
Johann C. Brandes, Paula M. Vertino, Fadlo R. Khuri, Gabriel L. Sica, Jeanne Kowalski, Khanjan Gandhi, Madhusmita Behera, Suresh S. Ramalingam, Hyunseok Kang, Adam El-Kommos, Ge Li, Seth A. Brodie
PDF file - 65K, Pathway analysis of differentially methylated genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427cbeb30d899be57926e5c6fc388acc
https://doi.org/10.1158/1940-6207.22524921
https://doi.org/10.1158/1940-6207.22524921
Autor:
Johann C. Brandes, Paula M. Vertino, Fadlo R. Khuri, Gabriel L. Sica, Jeanne Kowalski, Khanjan Gandhi, Madhusmita Behera, Suresh S. Ramalingam, Hyunseok Kang, Adam El-Kommos, Ge Li, Seth A. Brodie
DNA methylation is an early event in bronchial carcinogenesis and increased DNA methyltransferase (DNMT)1 protein expression is a crucial step in the oncogenic transformation of epithelia. Here, we investigate the role of class I histone deacetylases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9940561bce42ea6fb62ed9feb052ec91
https://doi.org/10.1158/1940-6207.c.6544488
https://doi.org/10.1158/1940-6207.c.6544488
Autor:
Johann C. Brandes, Paula M. Vertino, Fadlo R. Khuri, Gabriel L. Sica, Jeanne Kowalski, Khanjan Gandhi, Madhusmita Behera, Suresh S. Ramalingam, Hyunseok Kang, Adam El-Kommos, Ge Li, Seth A. Brodie
PDF file - 41K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b20e72e90ac616882adb319bb80a1a6
https://doi.org/10.1158/1940-6207.22524930.v1
https://doi.org/10.1158/1940-6207.22524930.v1
Autor:
Johann C. Brandes, Paula M. Vertino, Fadlo R. Khuri, Gabriel L. Sica, Jeanne Kowalski, Khanjan Gandhi, Madhusmita Behera, Suresh S. Ramalingam, Hyunseok Kang, Adam El-Kommos, Ge Li, Seth A. Brodie
PDF file - 1302K, S1: Primary transcript qPCR indicates HDAC1 and 2 are regulated transcriptionally, HDAC3 is not. S2: Analysis of golden gate methylation array identifies 42/807 genes hypermethylated after long term carcinogen exposure. S3: Cyclohex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2e8b61c92bab9079111493dd4344c5
https://doi.org/10.1158/1940-6207.22524927.v1
https://doi.org/10.1158/1940-6207.22524927.v1
Autor:
Johann C. Brandes, Fadlo R. Khuri, Taofeek K. Owonikoko, Suresh S. Ramalingam, Maria J.A. Ribeiro, Malcom V. Brock, James G. Herman, Dacian Bonta, Vijay A. Varma, Liu Yuan, Dana C. Nickleach, Ge Li, You Shaojin, Gabriel L. Sica, Seth A. Brodie, Rathi N. Pillai
PDF file - 53K, ROC curve to determine the best cutoff value for CHFR intensity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6739e28d03c83dc6fbaf06597af348dd
https://doi.org/10.1158/1078-0432.22450664
https://doi.org/10.1158/1078-0432.22450664
Autor:
Johann C. Brandes, Fadlo R. Khuri, Taofeek K. Owonikoko, Suresh S. Ramalingam, Maria J.A. Ribeiro, Malcom V. Brock, James G. Herman, Dacian Bonta, Vijay A. Varma, Liu Yuan, Dana C. Nickleach, Ge Li, You Shaojin, Gabriel L. Sica, Seth A. Brodie, Rathi N. Pillai
Purpose: Currently, there is no clinically validated test for the prediction of response to tubulin-targeting agents in non–small cell lung cancer (NSCLC). Here, we investigated the significance of nuclear expression of the mitotic checkpoint gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f972e9ec3464f5c6b8990e87aaae04
https://doi.org/10.1158/1078-0432.c.6521990.v1
https://doi.org/10.1158/1078-0432.c.6521990.v1
Autor:
David R. Mole, Lea Jessop, Virginia Schmid, Mitchell J. Machiela, Olivier Delattre, Grace C. Mills, Jiyeon Choi, Mark P. Purdue, Renato Cunha, Stephen J. Chanock, Leandro M. Colli, Olusegun O. Onabajo, Seth A. Brodie, Sabrina Y. Camp, Kai Yu, Kevin M. Brown, Timothy A. Myers
Publikováno v:
The American Journal of Human Genetics. 108:1590-1610
Our study investigated the underlying mechanism for the 14q24 renal cell carcinoma (RCC) susceptibility risk locus identified by a genome-wide association study (GWAS). The sentinel single-nucleotide polymorphism (SNP), rs4903064, at 14q24 confers an