Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Setareh Aflaki"'
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Ambre Petitalot, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Samuel Le Cam, Carlos Baliñas-Gavira, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood
Externí odkaz:
https://doaj.org/article/1b39f7921f8b45b382015dc3a19b069d
Autor:
Roberta Ragazzini, Raquel Pérez-Palacios, Irem H. Baymaz, Seynabou Diop, Katia Ancelin, Dina Zielinski, Audrey Michaud, Maëlle Givelet, Mate Borsos, Setareh Aflaki, Patricia Legoix, Pascal W. T. C. Jansen, Nicolas Servant, Maria-Elena Torres-Padilla, Deborah Bourc’his, Pierre Fouchet, Michiel Vermeulen, Raphaël Margueron
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Polycomb Repressive Complex 2 (PRC2) plays critical roles in transcriptional silencing during development. Here the authors identify EZHIP as a cofactor of PRC2 expressed predominantly in the gonads, finding that EZHIP limits the enzymatic activity o
Externí odkaz:
https://doaj.org/article/840ba9a727064edb97ff673ade34b357
Autor:
Pierre Romero, Laia Richart, Setareh Aflaki, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron
Mutations in chromatin regulators or their histone substrates are widespread in cancer and often play decisive roles in tumorigenesis. These include Polycomb Repressive Complex 2 (PRC2), a histone H3 lysine 27 methyltransferase that shows distinct al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cccdbebd006a04c359ddf5872a66b82
https://doi.org/10.1101/2023.01.02.522460
https://doi.org/10.1101/2023.01.02.522460
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2529
Elucidating the biological function of histone methyltransferases requires knowledge of the genomic sites at which they act. CUTRUN represents a valuable alternative to chromatin immunoprecipitation for the mapping of histone methylation patterns, ge
Publikováno v:
Histone Methyltransferases ISBN: 9781071624807
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c7fa81828cace42a5bea180185a99e
https://doi.org/10.1007/978-1-0716-2481-4_12
https://doi.org/10.1007/978-1-0716-2481-4_12
Autor:
Laia Richart, Mary-Loup Picod-Chedotel, Michel Wassef, Manon Macario, Setareh Aflaki, Marion A. Salvador, Tiphaine Héry, Aurélien Dauphin, Julien Wicinski, Véronique Chevrier, Sonia Pastor, Geoffrey Guittard, Samuel Le Cam, Hanya Kamhawi, Rémy Castellano, Géraldine Guasch, Emmanuelle Charafe-Jauffret, Edith Heard, Raphaël Margueron, Christophe Ginestier
Publikováno v:
Cell
Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩
Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩
X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis, promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is only beginning to be elucidated. Here, we demonstrate that XIST
Autor:
Christophe Ginestier, Emmanuelle Charafe-Jauffret, Mary-Loup Picod, Géraldine Guasch, Michel Wassef, Julien Wicinski, Setareh Aflaki, Edith Heard, Raphaël Margueron, Laia Richart, Véronique Chevrier, Samuel Le Cam, Manon Macario, Hanya A. Kamhawi, Marion A. Salvador, Rémy Castellano
Publikováno v:
SSRN Electronic Journal.
X-chromosome inactivation (XCI) is triggered by up-regulation of XIST, which coats the chromosome in cis and promotes recruitment of chromatin modifiers that transform the X into a silent heterochromatic domain. Whether XIST plays a role beyond initi
Autor:
Dina Zielinski, Cecilia Lövkvist, Damarys Loew, Setareh Aflaki, Michel Wassef, Raphaël Margueron, Bérangère Lombard, Daniel Holoch, Tiphaine Hery, Martin Howard
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, Nature Publishing Group, In press, ⟨10.1038/s41588-021-00964-2⟩
Nature Genetics, In press, ⟨10.1038/s41588-021-00964-2⟩
Epigenetic inheritance of gene expression states enables a single genome to maintain distinct cellular identities. How histone modifications contribute to this process remains unclear. Using global chromatin perturbations and local, time-controlled m
Autor:
Michel Wassef, Pierre-Alexandre Just, Setareh Aflaki, H. Irem Baymaz, Anne Vincent-Salomon, Nicolas Servant, Raphaël Margueron, Sébastien Jacques, Michel Vidaud, Mikael Hivelin, Pascal W.T.C. Jansen, Margaret R. Wallace, Carole Kersouani, Eric Pasmant, Armelle Luscan, Dina Zielinski, Aude Battistella, Pierre Romero, Olivier Kosmider, Michiel Vermeulen
Publikováno v:
Proceedings of the National Academy of Sciences USA, 116, 13, pp. 6075-6080
Proceedings of the National Academy of Sciences USA, 116, 6075-6080
Proceedings of the National Academy of Sciences USA, 116, 6075-6080
Genetic mutations affecting chromatin modifiers are widespread in cancers. In malignant peripheral nerve sheath tumors (MPNSTs), Polycomb repressive complex 2 (PRC2), which plays a crucial role in gene silencing, is inactivated through recurrent muta
Autor:
Patricia Legoix, Michiel Vermeulen, Déborah Bourc'his, Seynabou Diop, Raphaël Margueron, Roberta Ragazzini, Maria-Elena Torres-Padilla, Dina Zielinski, Katia Ancelin, Maëlle Givelet, Nicolas Servant, Setareh Aflaki, Pierre Fouchet, Audrey Michaud, Raquel Pérez-Palacios, Baymaz Hi, Pwtc Jansen, Máté Borsos
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10, pp.3858. ⟨10.1038/s41467-019-11800-x⟩
Nature Communications, 10
Nature Communications, 2019, 10, pp.3858. ⟨10.1038/s41467-019-11800-x⟩
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications, Nature Publishing Group, 2019, 10, pp.3858. ⟨10.1038/s41467-019-11800-x⟩
Nature Communications, 10
Nature Communications, 2019, 10, pp.3858. ⟨10.1038/s41467-019-11800-x⟩
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The Polycomb group of proteins is required for the proper orchestration of gene expression due to its role in maintaining transcriptional silencing. It is composed of several chromatin modifying complexes, including Polycomb Repressive Complex 2 (PRC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbac81ba51d5ec37bd6971dd8bd61bc4
https://hal.sorbonne-universite.fr/hal-02281453
https://hal.sorbonne-universite.fr/hal-02281453