Discovery of small molecule guanylyl cyclase A receptor positive allosteric modulators.

Autor: Sangaralingham SJ; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905; sangaralingham.jeson@mayo.edu smalany@cop.ufl.edu burnett.john@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905., Whig K; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Peddibhotla S; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.; Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610., Kirby RJ; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Sessions HE; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Maloney PR; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Hershberger PM; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Mose-Yates H; Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610., Hood BL; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Vasile S; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037., Pan S; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905., Zheng Y; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905., Malany S; Chemical Genomics Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037; sangaralingham.jeson@mayo.edu smalany@cop.ufl.edu burnett.john@mayo.edu.; Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610., Burnett JC Jr; Cardiorenal Research Laboratory, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905; sangaralingham.jeson@mayo.edu smalany@cop.ufl.edu burnett.john@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Dec 28; Vol. 118 (52).