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Akademický článek

Multiplexed single-cell imaging reveals diverging subpopulations with distinct senescence phenotypes during long-term senescence induction.

Autor: Sessions GA; Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, Unites States of America., Loops MV; Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, Unites States of America.; Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, United States of America., Diekman BO; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America.; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 and North Carolina State University, Raleigh, North Carolina 27695, United States of America., Purvis JE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, United States of America.; Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America.; Computational Medicine Program, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.

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Akademický článek

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.

Autor: Novais EJ; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, USA.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Portugal., Tran VA; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA., Johnston SN; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, USA., Darris KR; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA., Roupas AJ; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA., Sessions GA; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA., Shapiro IM; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, USA., Diekman BO; Thurston Arthritis Research Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, and North Carolina State University, Raleigh, NC, USA., Risbud MV; Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, USA. makarand.Risbud@jefferson.edu.; Graduate Program in Cell Biology and Regenerative Medicine, Jefferson College of Life Sciences, Thomas Jefferson University, Philadelphia, USA. makarand.Risbud@jefferson.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 03; Vol. 12 (1), pp. 5213. Date of Electronic Publication: 2021 Sep 03.

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Akademický článek

The combination of mitogenic stimulation and DNA damage induces chondrocyte senescence.

Autor: Copp ME; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: coppme@live.unc.edu., Flanders MC; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: mflande@ncsu.edu., Gagliardi R; NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: rgaglia@ncsu.edu., Gilbertie JM; NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: jmgilbe2@ncsu.edu., Sessions GA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: garrett_sessions@med.unc.edu., Chubinskaya S; Department of Pediatrics, Rush University Medical Center, Chicago, IL, USA. Electronic address: Susanna_Chubinskaya@rush.edu., Loeser RF; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Rheumatology, Allergy, and Immunology, University of North Carolina, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu., Schnabel LV; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; NC State College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: lvschnab@ncsu.edu., Diekman BO; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA; Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC, USA. Electronic address: bdiekman@email.unc.edu.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2021 Mar; Vol. 29 (3), pp. 402-412. Date of Electronic Publication: 2020 Nov 20.

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