Dose-dependent beneficial effects of citrulline supplementation in short bowel syndrome in rats

Autor: Stephanie Walrand, Nathalie Neveux, Virgine Lasserre, Jean Maccario, Servane Le Plénier, Amandine Rubio, Christophe Moinard, Luc Cynober, Xavier Hébuterne, Jerome Filippi

Publikováno v: Nutrition
Nutrition, Elsevier, 2021, 85, pp.111118. ⟨10.1016/j.nut.2020.111118⟩
Nutrition, 2021, 85, pp.111118. ⟨10.1016/j.nut.2020.111118⟩

International audience; Objectives: Supplementing diet with citrulline has proved an efficient means of preserving nitrogen balance and improving nutritional status after massive intestinal resection. The aim of this study was to model the action of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ea8786b0a91f0196bdb9185eae061c
https://pubmed.ncbi.nlm.nih.gov/33545544

Combining citrulline with atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity

Autor: Servane Le Plénier, Béatrice Morio, Chrystèle Jouve, Elodie Pitois, Christophe Moinard, Jean-Paul Rigaudière, Frédéric Capel, Luc Cynober, Gwladys Chabrier, Jean-Pascal De Bandt, Christine Durand

Publikováno v: British Journal of Pharmacology. 172:4996-5008

Background and Purpose NO is a crucial regulator of energy and lipid metabolism, whose homeostasis is compromised during obesity. Combination of citrulline and atorvastatin potentiated NO production in vitro. Here we have assessed the effects of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41ae7f71ee787111c84035dba18efff7
https://doi.org/10.1111/bph.13269

Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies

Autor: Athanassia Sotiropoulos, M. Jourdan, Stéphane Walrand, Arthur Goron, Chantal Guihenneuc, Jérôme Salles, Christophe Moinard, E. Archambault, Servane Le Plénier, Nathalie Neveux, Luc Cynober

Publikováno v: AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2017, 312 (1), pp.E27-E36. ⟨10.1152/ajpendo.00203.2016⟩
AJP-Endocrinology and Metabolism, 2017, 312 (1), pp.E27-E36. ⟨10.1152/ajpendo.00203.2016⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2017, 312 (1), pp.E27-E36. 〈10.1152/ajpendo.00203.2016〉
American Journal of Physiology. Endocrinology and Metabolism 1 (312), E27-E36. (2017)

Citrulline (CIT) is an endogenous amino acid produced by the intestine. Recent literature has consistently shown CIT to be an activator of muscle protein synthesis (MPS). However, the underlying mechanism is still unknown. Our working hypothesis was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4133f76bebec89581a8ace2ca26678
https://hal.archives-ouvertes.fr/hal-01594555

Evaluation of a new concept of immune-enhancing diet in a model of head-injured rat with infectious complications: A proof of concept study

Autor: Christine Charrueau, Servane Le Plénier, Jean-Pascal De Bandt, Michel-Francis Bureau, Nathalie Neveux, C. Choisy, Christophe Moinard, Saskia Brinkmann, Marie-José Butel, Luc Cynober, Françoise Brignole-Baudouin

Publikováno v: Clinical Nutrition
Clinical Nutrition, Elsevier, 2016, 35 (6), pp.1291-1300. ⟨10.1016/j.clnu.2016.04.018⟩
Clinical Nutrition, Elsevier, 2016, 35 (6), pp.1291-1300. ⟨10.1016/j.clnu.2016.04.018.⟩

International audience; Immune-enhancing diet (IED) utilization in critically ill septic patients is still debated. A new concept of IED has been proposed combining extra glutamine sequentially with either antioxidants or other amino acids, in order

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::632c8686a2f49fb2b05f6d9c5f38b7a9
https://pubmed.ncbi.nlm.nih.gov/27161521

Citrulline enhances myofibrillar constituents expression of skeletal muscle and induces a switch in muscle energy metabolism in malnourished aged rats

Autor: Béatrice Morio, Philippe Chafey, Servane Le Plénier, Christophe Moinard, Voahangy Randrianarison-Huetz, C. Faure, Christian Aussel, Philippe Noirez, Luc Cynober

Publikováno v: Proteomics
Proteomics, 2013, 13 (14), pp.2191-2201. ⟨10.1002/pmic.201200262⟩
Proteomics, Wiley-VCH Verlag, 2013, 13 (14), pp.2191-2201. ⟨10.1002/pmic.201200262⟩
Proteomics, Wiley-VCH Verlag, 2013, 13 (14), pp.2191-2201. 〈10.1002/pmic.201200262〉

We are grateful to Florence Blandel for carbonylated protein analysis. We would like to thank Morgane Le-Gall, Guilhem Clary, and Cedric Broussard for their help in the DIGE experiments and MS analysis. We also thank Professor E. Fontaine for helpful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cd49f2966aa270be5d60e1a81001c4
https://hal.science/hal-00986092