Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Serrine S. Lau"'
Publikováno v:
Toxicological Sciences. 171:117-131
2,3,5-Tris-(glutathion-S-yl)hydroquinone (TGHQ) is a nephrotoxic and nephrocarcinogenic metabolite of hydroquinone. TGHQ generates reactive oxygen species (ROS), causing DNA-strand breaks, hyperactivation of PARP-1, increases in intracellular calcium
Publikováno v:
Toxicol Sci
3, 4-Methylenedioxymethamphetamine (MDMA) is a hallucinogenic amphetamine derivative. The acute effects of MDMA are hyperthermia, hyperactivity, and behavioral changes, followed by long-term serotonergic neurotoxicity in rats and primates. However, t
Publikováno v:
Chemico-biological interactions. 302
2,3,5-tris(Glutathion-S-yl)hydroquinone (TGHQ), a potent nephrotoxic and nephroncarcinogenic metabolite of benzene and hydroquinone, retains the ability to redox cycle and create oxidative stress. We have previously detected that TGHQ induces ROS-dep
Autor:
Marilyn Halonen, Michael A. Galligan, Anne L. Wright, Terrence J. Monks, Dean Billheimer, Donata Vercelli, Haili Xu, Zhenqiang Lu, Serrine S. Lau, Timothy R. Radabaugh
Publikováno v:
Pediatric Allergy and Immunology. 27:696-701
Background Proteomic approaches identifying biomarkers have been applied to asthma to only a very limited extent. Methods With an antibody array (RayBiotech, Norcross, GA, USA), the relative intensity and rank differences of 444 proteins were compare
Autor:
Tiffanie L. Hargraves, Jixun Dai, Terrence J. Monks, Owen R. Kinsky, Neil E. Jacobsen, Serrine S. Lau, Shane A. Snyder, Tarun Anumol
Publikováno v:
Chemical Research in Toxicology. 29:227-234
Methylglyoxal (MG) is a highly reactive dicarbonyl compound involved in the formation of advanced glycation endproducts (AGE). Levels of MG are elevated in patients with type-2 diabetes mellitus (T2DM), and AGE have been implicated in the progression
Publikováno v:
The FASEB Journal. 32
Publikováno v:
The FASEB Journal. 32
Publikováno v:
The FASEB Journal. 32
Autor:
Terrence J. Monks, Ryan Canatsey, Matthew T. Labenski, Nicholas J. Mastrandrea, Serrine S. Lau, Jennifer D. Cohen
Publikováno v:
Molecular Carcinogenesis. 55:1243-1250
Increased activity of B-Raf has been identified in approximately 7% of human cancers. Treatment of Eker rats (Tsc-2(EK/+) ), bearing a mutation in one allele of the tuberous sclerosis-2 (Tsc-2) gene, with the nephrocarcinogen 2,3,5-tris-(glutathion-S
Autor:
Peter D. Reaven, Randall W. Nelson, Hussein N. Yassine, Angela M. Jackson, Christoph H. Borchers, Serrine S. Lau, Dobrin Nedelkov
Publikováno v:
Translational Proteomics, Vol 4, Iss C, Pp 18-24 (2014)
The oxidative modification of apolipoprotein A-I’s methionine148 (M148) is associated with defective HDL function in vitro. Multiple reaction monitoring (MRM) is a mass spectrometric technique that can be used to quantitate post-translational modif