The disease-causing tau V337M mutation induces tau hypophosphorylation and perturbs axon morphology pathways.

Autor: Mohl GA; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Dixon G; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., Marzette E; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., McKetney J; Gladstone Data Science and Biotechnology Institute, The J. David Gladstone Institutes, San Francisco, CA, USA.; Quantitative Bioscience Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Samelson AJ; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., Serras CP; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA USA., Jin J; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., Li A; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., Boggess SC; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA., Swaney DL; Gladstone Data Science and Biotechnology Institute, The J. David Gladstone Institutes, San Francisco, CA, USA.; Quantitative Bioscience Institute, University of California San Francisco, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA., Kampmann M; Institute for Neurodegenerative Diseases, University of California San Francisco, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 06. Date of Electronic Publication: 2024 Jun 06.