Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds.

Autor: Guilhon-Simplicio F; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Brazil., Serrão CKR; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Brazil., Pinto ACDS; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Brazil., Pacheco PAF; Department of Chemistry, Fluminense Federal University, Niterói, Brazil., Faria RX; Department of Chemistry, Fluminense Federal University, Niterói, Brazil., da Rocha DR; Department of Chemistry, Fluminense Federal University, Niterói, Brazil., Ferreira VF; Faculty of Pharmacy, Fluminense Federal University, Niterói, Brazil., Pereira-Junior RC; Superior Studies Center, Amazonas State University, Tefé, Brazil., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium., Baán A; Laboratory of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium., Kiekens F; Laboratory of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium., de Meneses Pereira M; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Brazil., Lima ES; Faculty of Pharmaceutical Sciences, Federal University of Amazonas, Manaus, Brazil., Winter H; Laboratory of Medicinal Chemistry, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium., Cos P; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Wilrijk, Belgium.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2022 Jun; Vol. 99 (6), pp. 868-883. Date of Electronic Publication: 2022 Mar 31.