Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5

Autor: Jiali Gong, Xiawei Li, Zengyu Feng, Jianyao Lou, Kaiyue Pu, Yongji Sun, Sien Hu, Yizhao Zhou, Tianyu Song, Meihua Shangguan, Kai Zhang, Wenjie Lu, Xin Dong, Jian Wu, Hong Zhu, Qiaojun He, Hongxia Xu, Yulian Wu

Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 11, Pp 2535-2547 (2024)

Abstract A rise in blood glucose is an early warning sign of underlying pancreatic cancer (PC) and may be an indicator of genetic events in PC progression. However, there is still a lack of mechanistic research on pancreatic cancer-associated new-ons

Externí odkaz: https://doaj.org/article/dcf956c28cb64e018df85b05eda87485

Serpin E1 mediates the induction of renal tubular degeneration and premature senescence upon diabetic insult.

Autor: Chen, Bo Han^1,2 (AUTHOR), Lu, Xiao Qing¹ (AUTHOR), Liang, Xian Hui¹ (AUTHOR), Wang, Pei^1,2,3 (AUTHOR) wpei@zzu.edu.cn

Publikováno v: Scientific Reports. 9/27/2023, Vol. 13 Issue 1, p1-11. 11p.

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Author Correction: Sorcin can trigger pancreatic cancer-associated new-onset diabetes through the secretion of inflammatory cytokines such as serpin E1 and CCL5.

Autor: Gong J; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.; Department of Surgery, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China., Li X; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.; Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA., Feng Z; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Lou J; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Pu K; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Sun Y; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.; Department of Surgery, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China., Hu S; Department of Surgery, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China., Zhou Y; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Song T; Department of Surgery, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China., Shangguan M; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Zhang K; School of Public Health and Eye Center The Second Affiliated Hospital, Zhejiang University, Hangzhou, China., Lu W; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Dong X; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China., Wu J; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; School of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Institute of Wenzhou, Zhejiang University, Wenzhou, Zhejiang, China., Zhu H; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China.; Center for Drug Safety Evaluation and Research of Zhejiang University, Hangzhou, Zhejiang, China., He Q; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. qiaojunhe@zju.edu.cn.; Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. qiaojunhe@zju.edu.cn.; Center for Drug Safety Evaluation and Research of Zhejiang University, Hangzhou, Zhejiang, China. qiaojunhe@zju.edu.cn., Xu H; Innovation Institute for Artificial Intelligence in Medicine and Liangzhu Laboratory, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. Einstein@zju.edu.cn., Wu Y; Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. yulianwu@zju.edu.cn.; Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Cancer Institute, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. yulianwu@zju.edu.cn.; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China. yulianwu@zju.edu.cn.; Department of Surgery, Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China. yulianwu@zju.edu.cn.

Publikováno v: Experimental & molecular medicine [Exp Mol Med] 2024 Nov; Vol. 56 (11), pp. 2549.

Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis

Autor: Xueshu Chen, Wei Chen, Yan Zhao, Qinrong Wang, Wenling Wang, Yining Xiang, Hang Yuan, Yuan Xie, Jianjiang Zhou

Publikováno v: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-17 (2022)

Abstract Background Helicobacter pylori (H. pylori) can disrupt the tight junctions between gastric epithelial cells and penetrate the intercellular spaces acting on epithelial cells, normal fibroblasts (NFs), and cancer-associated fibroblasts (CAFs)

Externí odkaz: https://doaj.org/article/7571921e91a54ec18e6677f21c15452d