Zobrazeno 1 - 10
of 403
pro vyhledávání: '"Serotonin transport"'
Autor:
Alexander T. Young, Kien N. Ly, Callum Wilson, Klaus Lehnert, Russell G. Snell, Suzanne J. Reid, Jessie C. Jacobsen
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
Brain dopamine-serotonin vesicular transport disease is a rare disease caused by autosomal recessive mutations in the SLC18A2 gene, which encodes the VMAT2 protein. VMAT2 is a membrane protein responsible for vesicular transport of monoamines, and it
Externí odkaz:
https://doaj.org/article/fae458ff799740f39e42bfda3ada7ec0
Autor:
Laura L. Hernandez, M.K. Connelly
Publikováno v:
JDS Communications. 2:289-294
Serotonin's role as a hormone has been demonstrated through modulating calcium metabolism, energy homeostasis, and immune function in the preweaned and lactating bovine. Recently, manipulation of the serotonergic axis in calves via administration of
Autor:
Iris E. Kalenderoglou, Per Plenge, Claus J. Loland, Louise Laursen, Eric Gouaux, Amy Hauck Newman, Jonathan A. Coleman, Dongxue Yang, Kristine Salomon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Plenge, P, Yang, D, Salomon, K, Laursen, L, Kalenderoglou, I E, Newman, A H, Gouaux, E, Coleman, J A & Loland, C J 2021, ' The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter ', Nature Communications, vol. 12, no. 1, 5063 . https://doi.org/10.1038/s41467-021-25363-3
Nature Communications
Plenge, P, Yang, D, Salomon, K, Laursen, L, Kalenderoglou, I E, Newman, A H, Gouaux, E, Coleman, J A & Loland, C J 2021, ' The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter ', Nature Communications, vol. 12, no. 1, 5063 . https://doi.org/10.1038/s41467-021-25363-3
Depression is a common mental disorder. The standard medical treatment is the selective serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of the serotonin transporter (SERT). A non-competitive inhibitor may pro
Publikováno v:
Journal of Pharmaceutical Research International. :123-127
Background: The misdiagnosis rate for mood disorders is high. Psychiatric literature is in much need of a more objective and quantitative tool for the investigation of mood disorders. Although SPECT has been previously used in research for the unders
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Translational Psychiatry
Translational Psychiatry
The effects of different forms of monosaccharides on the brain remain unclear, though neuropsychiatric disorders undergo changes in glucose metabolism. This study assessed cell viability responses to five commonly consumed monosaccharides—D-ribose
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 45, Iss 10, Pp 948-954 (2012)
Visceral hypersensitivity plays an important role in motor and sensory abnormalities associated with irritable bowel syndrome, but the underlying mechanisms are not fully understood. The present study was designed to evaluate the expression of the 5-
Externí odkaz:
https://doaj.org/article/b6accac8f0da4322992cccde886af260
Autor:
Andy R. Eugene, Duan Liu, Richard M. Weinshilboum, Sisi Qin, Liewei Wang, Lingxin Zhang, Joanna M. Biernacka, Jia Yu, Drew Neavin
Publikováno v:
Clinical Pharmacology and Therapeutics
We previously reported that testis-specific Y-encoded-like protein (TSPYLs) are transcription regulators for CYP3A4, CYP2C9, and CYP2C19. Here, we observed dual roles for TSPYLs in mediating serotonin transport and the metabolism of selective seroton
Publikováno v:
Bioelectricity
Selective serotonin reuptake inhibitor (SSRI) drugs, targeting serotonin transport, are widely used. A puzzling and biomedically important phenomenon concerns the persistent sexual dysfunction following SSRI use seen in some patients. What could be t
Publikováno v:
The FASEB Journal. 35
Autor:
Walter Sandtner, Gary Rudnick
Publikováno v:
The Journal of General Physiology
Rudnick and Sandtner review the history of serotonin transporter research in light of structural and electrophysiological advances.
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), w
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), w