Výsledky vyhledávání - "Serotonin Plasma Membrane Transport Proteins/genetics"

Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice

Autor: Mithula Sivasaravanaparan, Louise Ørum Olesen, Maurizio Severino, Christian Ulrich von Linstow, Kate Lykke Lambertsen, Jan Bert Gramsbergen, Jørgen Hasselstrøm, Athanasios Metaxas, Ove Wiborg, Bente Finsen

Publikováno v: Sivasaravanaparan, M, Olesen, L Ø, Severino, M, von Linstow, M C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APPSWE/PS1ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019
Sivasaravanaparan, M, Olesen, L Ø, Severino, M, Von Linstow, C U, Lambertsen, K L, Gramsbergen, J B, Hasselstrøm, J, Metaxas, A, Wiborg, O & Finsen, B 2022, ' Efficacy of Chronic Paroxetine Treatment in Mitigating Amyloid Pathology and Microgliosis in APP SWE/PS1 ΔE9 Transgenic Mice ', Journal of Alzheimer's Disease, vol. 87, no. 2, pp. 685-699 . https://doi.org/10.3233/JAD-220019

BACKGROUND: Modulation of serotonergic signaling by treatment with selective serotonin reuptake inhibitors (SSRIs) has been suggested to mitigate amyloid-β (Aβ) pathology in Alzheimer's disease, in addition to exerting an anti-depressant action.OBJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4714a1ec2df8b56653e6f414046de850
https://pubmed.ncbi.nlm.nih.gov/35342093

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The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks

Autor: Meer, Dennis, Hartman, Catharina A., Pruim, Raimon H. R., Mennes, Maarten, Heslenfeld, Dirk, Oosterlaan, Jaap, Faraone, Stephen V., Barbara Franke, Buitelaar, Jan K., Hoekstra, Pieter J.

Publikováno v: Brain imaging and behavior, 11(5), 1486-1496. Springer New York
Brain Imaging and Behavior, 11, 5, pp. 1486-1496
ResearcherID
Brain Imaging and Behavior, 11(5), 1486-1496. SPRINGER
van der Meer, D, Hartman, C A, Pruim, R H, Mennes, M, Heslenfeld, D J, Oosterlaan, J, Faraone, S V, Franke, B, Buitelaar, J K & Hoekstra, P J 2017, ' The interaction between 5-HTTLPR and stress exposure influences connectivity of the executive control and default mode brain networks ', Brain Imaging and Behavior, vol. 11, no. 5, pp. 1486-1496 . https://doi.org/10.1007/s11682-016-9633-3
Brain Imaging and Behavior, 11, 1486-1496
Brain Imaging and Behavior
Brain Imaging and Behavior, 11(5), 1486-1496. Springer New York

We recently reported that the serotonin transporter polymorphism 5-HTTLPR moderates the relation between stress exposure and attention-deficit/hyperactivity disorder (ADHD) severity. This gene-environment interaction (GxE) has been previously tied to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e913bf3cee4eb197e19919a943003468
https://hdl.handle.net/1871.1/3c83d1c0-3b05-4e61-ad08-2af569a39086

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Interplay between stress response genes associated with attention-deficit hyperactivity disorder and brain volume

Publikováno v: Genes, Brain and Behavior. 15(7):627-636

The glucocorticoid receptor plays a pivotal role in the brain's response to stress; a haplotype of functional polymorphisms in the NR3C1 gene encoding this receptor has been associated with attention-deficit hyperactivity disorder (ADHD). The seroton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::9a9f4f51ff3c1451f6acccbc1978fd6b
https://doi.org/10.1111/gbb.12307

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Interplay between stress response genes associated with attention-deficit hyperactivity disorder and brain volume

Publikováno v: Genes, Brain and Behavior. 15(7):627-636

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::937ecd210ef513c36ad1b04f96586b53
https://doi.org/10.1111/gbb.12307

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ADHD Symptoms in Middle Adolescence Predict Exposure to Person-Related Life Stressors in Late Adolescence in 5-HTTLPR S-allele Homozygotes

Autor: Annelies de Bildt, Andrea Dietrich, Djûke M Brinksma, Catharina A. Hartman, Barbara J. van den Hoofdakker, Jan K. Buitelaar, Pieter J. Hoekstra

Publikováno v: Journal of Abnormal Child Psychology, 46(7), 1427-1437. SPRINGER/PLENUM PUBLISHERS
Journal of Abnormal Child Psychology, 46, 1427-1437
Journal of Abnormal Child Psychology, 46, 7, pp. 1427-1437

Contains fulltext : 196243.pdf (Publisher’s version ) (Closed access) Literature suggests that life stressors predict attention-deficit/hyperactivity disorder (ADHD) symptoms and that this relationship is moderated by the serotonin transporter poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbabcb77ee44620b8f6637f25bd498fd
https://research.rug.nl/en/publications/77fc8e1a-6f96-4630-93d5-362513888bf0

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Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder

Autor: Marcel Romanos, Susanne Walitza, Elena Gardini, Julia Geissler, Tomasz K. Wojdacz, Zoya Marinova, Juliane Ball, Edna Grünblatt, Alexander Roth

Publikováno v: Grünblatt, E, Marinova, Z, Roth, A, Gardini, E, Ball, J, Geissler, J, Wojdacz, T K, Romanos, M & Walitza, S 2018, ' Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder ', Journal of Psychiatric Research, vol. 96, pp. 209-217 . https://doi.org/10.1016/j.jpsychires.2017.10.010

While genetic variants have been reported to be associated with obsessive-compulsive disorder (OCD), the small effect sizes suggest that epigenetic mechanisms such as DNA methylation may also be relevant. The serotonin transporter (SLC6A4) gene has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11679c7cf89ef260bf61c343b03d5d86
https://pure.au.dk/portal/da/publications/combining-genetic-and-epigenetic-parameters-of-the-serotonin-transporter-gene-in-obsessivecompulsive-disorder(37a7da3c-f75b-4d77-a589-f2abbac02b37).html

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Depressive mood ratings are reduced by MDMA in female polydrug ecstasy users homozygous for the l-allele of the serotonin transporter

Autor: Magí Farré, Kim P. C. Kuypers, R. de la Torre, Eef L. Theunissen, E. B. de Sousa Fernandes Perna, Laura Xicota, Johannes G. Ramaekers

Publikováno v: Scientific Reports
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Recercat. Dipósit de la Recerca de Catalunya
Scientific Reports, 8:1061. Nature Publishing Group
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)

MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a80332d472534e667a5aab3096655a5
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5867

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Interplay between stress response genes associated with attention-deficit hyperactivity disorder and brain volume

Autor: van der Meer, D., Hoekstra, P.J., Bralten, J., Donkelaar, M.M.J., Heslenfeld, D.J., Oosterlaan, J., Faraone, S.V., Franke, B., Buitelaar, J.K., Hartman, C.A.

Publikováno v: Genes, brain, and behavior, 15(7), 627-636. Wiley-Blackwell
Genes, Brain and Behavior, 15, 627-36
Genes, Brain and Behavior, 15(7), 627-636. Wiley-Blackwell
Genes, Brain and Behavior, 15(7), 627-636. Wiley-Blackwell Publishing
Genes, Brain and Behavior, 15, 7, pp. 627-36
van der Meer, D, Hoekstra, P J, Bralten, J, Donkelaar, M M J, Heslenfeld, D J, Oosterlaan, J, Faraone, S V, Franke, B, Buitelaar, J K & Hartman, C A 2016, ' Interplay between stress response genes associated with attention-deficit hyperactivity disorder and brain volume ', Genes, Brain and Behavior, vol. 15, no. 7, pp. 627-636 . https://doi.org/10.1111/gbb.12307

Contains fulltext : 167897.pdf (Publisher’s version ) (Open Access) The glucocorticoid receptor plays a pivotal role in the brain's response to stress; a haplotype of functional polymorphisms in the NR3C1 gene encoding this receptor has been associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::240f98a401d9700f5c4e5c3f25b79719
https://pure.amc.nl/en/publications/interplay-between-stress-response-genes-associated-with-attentiondeficit-hyperactivity-disorder-and-brain-volume(3fa9850a-d57b-4d3a-be33-5ce4df0c2aa3).html

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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Publikováno v: BMC Psychiatry
BMC Psychiatry, 13. BioMed Central
Culverhouse, R C, Bowes, L, Saccone, N L, Bierut, L J, 5-HTTLPR, Stress, and Depression Consortium, Boomsma, D, de Geus, E J C, Draisma, H, Hottenga, J J, Middeldorp, C M, Minica, C C, W J H Penninx, B & Willemsen, G 2013, ' Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression ', BMC Psychiatry, vol. 13, pp. 304 . https://doi.org/10.1186/1471-244X-13-304

Background: Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e211fce038c8fa79aadaf1d73bcc4a
https://hdl.handle.net/1871.1/adb5cd32-d078-430f-955a-13354b10624b

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