Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Serkan, Belkaya"'
Rational design of monomeric IL37 variants guided by stability and dynamical analyses of IL37 dimers
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1854-1863 (2024)
IL37 plays important roles in the regulation of innate immunity and its oligomeric status is critical to these roles. In its monomeric state, IL37 can effectively inhibit the inflammatory response of IL18 by binding to IL18Rα, a capacity lost in its
Externí odkaz:
https://doaj.org/article/895bd76b02e24ab0b70bbdf4a5b226cc
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3522-3531 (2023)
Interleukin 18 (IL18) is a pro-inflammatory cytokine that modulates innate and adaptive immune responses. IL18 activity is tightly controlled by the constitutively secreted IL18 binding protein (IL18BP). PDB structures of human IL18 showed that a sho
Externí odkaz:
https://doaj.org/article/99a243f588fd496c95e01366b76c68b7
Autor:
Fatma S. Coskun, Shashikant Srivastava, Prithvi Raj, Igor Dozmorov, Serkan Belkaya, Smriti Mehra, Nadia A. Golden, Allison N. Bucsan, Moti L. Chapagain, Edward K. Wakeland, Deepak Kaushal, Tawanda Gumbo, Nicolai S. C. van Oers
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Nearly one third of the world’s population is infected with Mycobacterium tuberculosis (Mtb). While much work has focused on the role of different Mtb encoded proteins in pathogenesis, recent studies have revealed that Mtb also transcribes many non
Externí odkaz:
https://doaj.org/article/06e35103ef2d41e9bd53d7eb9f6e5990
Autor:
Zeynep Güneş Tepe, Yılmaz Yücehan Yazıcı, Umut Tank, Ladin Işık Köse, Murat Özer, Caner Aytekin, Serkan Belkaya
Publikováno v:
Journal of Clinical Immunology
Human herpesvirus-6 (HHV-6) infection can rarely cause life-threatening conditions, such as encephalitis, in otherwise healthy children, with unclear pathogenesis. We studied a child who presented with acute HHV-6 encephalitis at the age of 10 months
Autor:
Veysel Gök, Şerife Erdem, Yeşim Haliloğlu, Atıl Bişgin, Serkan Belkaya, Kemal Erdem Başaran, Mehmed Fatih Canatan, Alper Özcan, Ebru Yılmaz, Can Acıpayam, Musa Karakükcü, Halit Canatan, Hüseyin Per, Türkan Patıroğlu, Ahmet Eken, Ekrem Ünal
Publikováno v:
Genes and Immunity
Insufficient dietary folate intake, hereditary malabsorption, or defects in folate transport may lead to combined immunodeficiency (CID). Although loss of function mutations in the major intestinal folate transporter PCFT/SLC46A1 was shown to be asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0edea6ed55d70a1217e8f6a063bc38e
https://avesis.erciyes.edu.tr/publication/details/cc9b5c39-00d9-4e3f-baef-1b60d6bf37fa/oai
https://avesis.erciyes.edu.tr/publication/details/cc9b5c39-00d9-4e3f-baef-1b60d6bf37fa/oai
Autor:
Cecilia B. Korol, Serkan Belkaya, Fahad Alsohime, Lazaro Lorenzo, Stéphanie Boisson-Dupuis, Joseph Brancale, Anna-Lena Neehus, Silvia Vilarinho, Alsum Zobaida, Rabih Halwani, Saleh Al-Muhsen, Jean-Laurent Casanova, Emmanuelle Jouanguy
Publikováno v:
Journal of Clinical Immunology
Fulminant viral hepatitis (FVH) caused by hepatitis A virus (HAV) is a life-threatening disease that typically strikes otherwise healthy individuals. The only known genetic etiology of FVH is inherited IL-18BP deficiency, which unleashes IL-18-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4459f511cf19b089f64d367eb35fc39b
https://hdl.handle.net/11693/112035
https://hdl.handle.net/11693/112035
Autor:
Ekrem Unal, Veysel GOK, Serife Erdem, Yesim Haliloglu, Atil BISGIN, Serkan Belkaya, Kemal Basaran, Alper Ozcan, Ebru Yılmaz, Can Acıpayam, Musa KARAKUKCU, Halit Canatan, Hüseyin Per, Türkan Patıroglu, Ahmet Eken
Insufficient dietary folate intake, hereditary malabsorption, or defects in folate metabolism may lead to combined immunodeficiency (CID). Although loss of function mutations in the major intestinal folate transporter PCFT/SLC46A1 was shown to be ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae18030ee88593d14161a782ff256da
https://doi.org/10.21203/rs.3.rs-1866280/v1
https://doi.org/10.21203/rs.3.rs-1866280/v1
Autor:
Fatima Al Ali, Laurent Abel, Jean-François Emile, Davood Mansouri, Mahbuba Rahman, Franck Rapaport, Stéphanie Boisson-Dupuis, Nicholas Hernandez, Taushif Khan, Anna-Lena Neehus, David Hum, Benedetta Bigio, Vivien Béziat, Nico Marr, Jean-Laurent Casanova, Scott Drutman, Jacinta Bustamante, Emmanuelle Jouanguy, Majid Marjani, Robert Fisch, Ruslana Bryk, Nahal Mansouri, Serkan Belkaya, Lazaro Lorenzo-Diaz, Carl Nathan, Seyed Alireza Mahdaviani
Publikováno v:
N Engl J Med
BACKGROUND: Cytomegalovirus (CMV) can cause severe disease in children and adults with a variety of inherited or acquired T-cell immunodeficiencies, who are prone to multiple infections. It can also rarely cause disease in otherwise healthy persons.
Autor:
Serkan Belkaya
Publikováno v:
Journal of İzmir Chest Hospital.
Autor:
Rui Yang, Rubén Martínez-Barricarte, Janet Markle, Franck Rapaport, Stuart G. Tangye, Mathieu Bourgey, David Langlais, Anne Puel, Aziz Belkadi, Masato Ogishi, Simon J. Pelham, Jean-Laurent Casanova, Bertrand Boisson, Cindy S. Ma, Vivien Béziat, Eman Abou Moussa, Jérémie Rosain, Laurent Abel, Tomi Lazarov, Serkan Belkaya, Fatima Ailal, Ibtihal Benhsaien, Coralie Briand, Alessandro Plebani, Romain Lévy, Frederic Geissmann, Caroline Deswarte, Andrea Guennoun, Luis R. Saraiva, Tanwir Habib, Mehdi Emam, Vassilios Lougaris, Philippe Gros, Yu Jerry Zhou, Ahmed Aziz Bousfiha, Geetha Rao, Kathryn Payne, Sylvain Breton, Ai Ing Lim, Kang Liu, Kunihiko Moriya, Danielle T. Avery, Bénédicte Neven, Nico Marr, Jacinta Bustamante, Mélanie Migaud, James P. Di Santo
Publikováno v:
J Clin Invest
We studied a child with severe viral, bacterial, fungal, and parasitic diseases, who was homozygous for a loss-of-function mutation of REL, encoding c-Rel, which is selectively expressed in lymphoid and myeloid cells. The patient had low frequencies