Zobrazeno 1 - 10
of 993
pro vyhledávání: '"Serial crystallography"'
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 831-842 (2024)
Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical
Externí odkaz:
https://doaj.org/article/d0903ee406ef420fbf37bb2ad65ec080
Autor:
Nicolas Foos, Jean-Baptise Florial, Mathias Eymery, Jeremy Sinoir, Franck Felisaz, Marcus Oscarsson, Antonia Beteva, Matthew W. Bowler, Didier Nurizzo, Gergely Papp, Montserrat Soler-Lopez, Max Nanao, Shibom Basu, Andrew A. McCarthy
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 780-791 (2024)
The advent of serial crystallography has rejuvenated and popularized room-temperature X-ray crystal structure determination. Structures determined at physiological temperature reveal protein flexibility and dynamics. In addition, challenging samples
Externí odkaz:
https://doaj.org/article/cf4a521d492f440fa7ef91fbdf26672a
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 538-555 (2024)
Crystallography is a quintessential method for determining the atomic structure of crystals. The most common implementation of crystallography uses single crystals that must be of sufficient size, typically tens of micrometres or larger, depending on
Externí odkaz:
https://doaj.org/article/bd897adbad6a4517bb8f6d343b9bebdd
Autor:
Marina Galchenkova, Alexandra Tolstikova, Bjarne Klopprogge, Janina Sprenger, Dominik Oberthuer, Wolfgang Brehm, Thomas A. White, Anton Barty, Henry N. Chapman, Oleksandr Yefanov
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 190-201 (2024)
Serial crystallography (SX) has become an established technique for protein structure determination, especially when dealing with small or radiation-sensitive crystals and investigating fast or irreversible protein dynamics. The advent of newly devel
Externí odkaz:
https://doaj.org/article/7172b08f189341d2b6450e8be4c657b5
Autor:
Jack Stubbs, Theo Hornsey, Niall Hanrahan, Luis Blay Esteban, Rachel Bolton, Martin Malý, Shibom Basu, Julien Orlans, Daniele de Sanctis, Jung-uk Shim, Patrick D. Shaw Stewart, Allen M. Orville, Ivo Tews, Jonathan West
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 237-248 (2024)
Serial crystallography requires large numbers of microcrystals and robust strategies to rapidly apply substrates to initiate reactions in time-resolved studies. Here, we report the use of droplet miniaturization for the controlled production of unifo
Externí odkaz:
https://doaj.org/article/c195768e5720466ea37cb52c3fb1391d
Autor:
Filip Leonarski, Jie Nan, Zdenek Matej, Quentin Bertrand, Antonia Furrer, Ishkhan Gorgisyan, Monika Bjelčić, Michal Kepa, Hannah Glover, Viktoria Hinger, Thomas Eriksson, Aleksander Cehovin, Mikel Eguiraun, Piero Gasparotto, Aldo Mozzanica, Tobias Weinert, Ana Gonzalez, Jörg Standfuss, Meitian Wang, Thomas Ursby, Florian Dworkowski
Publikováno v:
IUCrJ, Vol 10, Iss 6, Pp 729-737 (2023)
Serial and time-resolved macromolecular crystallography are on the rise. However, beam time at X-ray free-electron lasers is limited and most third-generation synchrotron-based macromolecular crystallography beamlines do not offer the necessary infra
Externí odkaz:
https://doaj.org/article/c27c457b830e451aab9a87a194dd5a8f
Autor:
Melissa Carrillo, Thomas J. Mason, Agnieszka Karpik, Isabelle Martiel, Michal W. Kepa, Katherine E. McAuley, John H. Beale, Celestino Padeste
Publikováno v:
IUCrJ, Vol 10, Iss 6, Pp 678-693 (2023)
Fixed targets are a popular form of sample-delivery system used in serial crystallography at synchrotron and X-ray free-electron laser sources. They offer a wide range of sample-preparation options and are generally easy to use. The supports are typi
Externí odkaz:
https://doaj.org/article/f31843acb84745068e23828005e2d59c
Akademický článek
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Autor:
Ki Hyun Nam
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100131- (2024)
Serial crystallography (SX) is an emerging technique that can be used to determine the noncryogenic crystal structure of macromolecules while minimizing radiation damage. Applying SX using pump-probe or mix-and-inject techniques enables the observati
Externí odkaz:
https://doaj.org/article/175f4cd992c44e9e99f848d1f370e156
Autor:
Ki Hyun Nam
Publikováno v:
Crystals, Vol 14, Iss 3, p 276 (2024)
Temperature directly influences the function and structure of proteins. Crystal structures determined at room temperature offer more biologically relevant structural information regarding flexibility, rigidity, and thermal motion than those determine
Externí odkaz:
https://doaj.org/article/1e6d9995c85344868050387e05e4fa0a