Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Serhii Holota"'
Autor:
Edyta Kaleniuk, Serhii Holota, Bartosz Skóra, Dmytro Khylyuk, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Applied Sciences, Vol 14, Iss 17, p 7692 (2024)
Presently, a major challenge is the search for new compounds that may exhibit an inhibitory effect on tumor progression. Recently, the 4-thiazolidinone (4-TZD) group has gained attention in this research field. The aim of the present study was to eva
Externí odkaz:
https://doaj.org/article/6df93435b7b948128ec84dbc5f1cd4db
Autor:
Nataliya Finiuk, Yuliia Kozak, Agnieszka Gornowicz, Robert Czarnomysy, Marlena Tynecka, Serhii Holota, Marcin Moniuszko, Rostyslav Stoika, Roman Lesyk, Krzysztof Bielawski, Anna Bielawska
Publikováno v:
Cancers, Vol 16, Iss 16, p 2924 (2024)
The development of new, effective agents for the treatment of breast cancer remains a high-priority task in oncology. A strategy of treatment for this pathology depends significantly on the genotype and phenotype of human breast cancer cells. We aime
Externí odkaz:
https://doaj.org/article/10827a65300f456288e7b34a9e9fff3e
Autor:
Dominika Szlachcikowska, Anna Tabęcka-Łonczyńska, Serhii Holota, Olexandra Roman, Yulia Shepeta, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7329 (2024)
A range of hybrid molecules incorporating the ciminalum moiety in the thiazolidinone ring demonstrate significant anticancer and antimicrobial properties. Therefore, the aim of our study was to evaluate the properties and mechanism of action of two 4
Externí odkaz:
https://doaj.org/article/65c0530f214b49cba12dbb893211fada
Role of 4-Thiazolidinone–Pyrazoline/Indoline Hybrids Les-4369 and Les-3467 in BJ and A549 Cell Lines
Autor:
Karolina Kosińska, Bartosz Skóra, Serhii Holota, Yulia Shepeta, Anna Tabęcka-Łonczyńska, Roman Lesyk, Konrad A. Szychowski
Publikováno v:
Cells, Vol 13, Iss 12, p 1007 (2024)
Cancer is one of the most important problems of modern societies. Recently, studies have reported the anticancer properties of rosiglitazone related to its ability to bind peroxisome proliferator receptor γ (PPARγ), which has various effects on can
Externí odkaz:
https://doaj.org/article/2888d91256ec4667861eaaf5050a1ada
Autor:
Ivanna Danyliuk, Nataliia Kovalenko, Valentyna Tolmachova, Olena Kovtun, Lesya Saliyeva, Nataliia Slyvka, Serhii Holota, Gennady Kutrov, Magdalina Tsapko, Mykhailo Vovk
Publikováno v:
Current Chemistry Letters, Vol 12, Iss 4, Pp 667-676 (2023)
The 4-bromomethyl-substituted thiazolium salts and corresponding thiazoles obtained through the condensation of 1,3-dibromoacetone with thioamide derivatives were utilised as efficient alkylating reagents for a series of thiophenols and heterylthiols
Externí odkaz:
https://doaj.org/article/42f4e2137de2485aa3f534909f580579
Autor:
Nataliia Slyvka, Lesya Saliyeva, Serhii Holota, Mariia Litvinchuk, Svitlana Shishkina, Mykhailo Vovk
Publikováno v:
Current Chemistry Letters, Vol 12, Iss 2, Pp 335-342 (2023)
Here derivatives of imidazo[2,1-b][1,3]thiazines are attractive objects for organic and medicinal chemists. In the present work chemoselective conditions for oxidation of the sulfur atom in the 6-(2-pyridinyloxy)substituted (benzo)imidazo[2,1-b][1,3]
Externí odkaz:
https://doaj.org/article/982c315e0b4a47a9bd084dc5d133893b
Autor:
Yulian Konechnyi, Tetyana Rumynska, Ihor Yushyn, Serhii Holota, Vira Turkina, Mariana Ryviuk Rydel, Alicja Sękowska, Yuriy Salyha, Olena Korniychuk, Roman Lesyk
Publikováno v:
Antibiotics, Vol 13, Iss 4, p 291 (2024)
A novel 4-thiazolidinone derivative Les-6490 (pyrazol-4-thiazolidinone hybrid) was designed, synthesized, and characterized by spectral data. The compound was screened for its antimicrobial activity against some pathogenic bacteria and fungi and show
Externí odkaz:
https://doaj.org/article/1fe990877e5043d8bb151b679fcdd08c
Publikováno v:
Molecules, Vol 29, Iss 2, p 346 (2024)
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer. In particular, aromatase catalyzes the conversion of androgens (male hormones) into
Externí odkaz:
https://doaj.org/article/7723771bfe3a416da326cb5751e78555
Autor:
Olga Klaudia Szewczyk-Roszczenko, Piotr Roszczenko, Anna Shmakova, Nataliya Finiuk, Serhii Holota, Roman Lesyk, Anna Bielawska, Yegor Vassetzky, Krzysztof Bielawski
Publikováno v:
Cells, Vol 12, Iss 18, p 2312 (2023)
Endocytosis is one of the major ways cells communicate with their environment. This process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic transformation. Here, we review the approaches to inhibit endocytosis, dis
Externí odkaz:
https://doaj.org/article/240d6a12375b49b7b04c384bef8ac300
Publikováno v:
Pharmacia, Vol 68, Iss 4, Pp 933-939 (2021)
Methodological bases and uniform standardization criteria of humic compounds as substances for drug products have not been developed yet. This is due to the structural complexity of humic compounds, the variety of ways to extract them from natural ob
Externí odkaz:
https://doaj.org/article/b7794a43f31744a994d64880248f1af8